(Press-News.org) A study led by Manchester scientists has shown promising results for a new treatment approach in follicular lymphoma.
Follicular lymphoma is a type of non-Hodgkin's lymphoma– a blood cancer - that usually develops slowly. The majority of patients are diagnosed when their disease is at an advanced stage.
Recent improvements in treatment have included the use of antibodies to specifically target the tumour cells and to stimulate the patient's own immune system to attack their tumour. The use of such antibodies has improved treatment response, but unfortunately most patients still relapse.
Radioimmunotherapy – where a radioactive substance is attached to the antibody – has been shown to be successful in treating patients who had previously relapsed.
Now a team involving researchers from The University of Manchester – part of the Manchester Cancer Research Centre - has investigated the use of radioimmunotherapy treatment in newly diagnosed patients.
The study published in the Journal of Clinical Oncology, looked at the effect of delivering the treatment in two fractions or doses – this approach is thought to improve the penetration of the drug within larger tumours and also helps reduce the side effects associated with a full dose treatment.
Professor Tim Illidge, who led the research, said: "This was the first study to look at giving two fractions of radioimmunotherapy as an initial treatment in follicular lymphoma. We wanted to assess its safety and effectiveness in a group of high-risk patients who conventionally have done less well."
The researchers found that that their treatment plan was feasible and safe, with very few side effects.
"We saw a high overall response rate, of 94.4%, and 50 of the 72 (69.4%) patients treated in the study achieved complete response – meaning their symptoms disappeared. These results are encouraging, but we need further studies in larger numbers of patients to fully compare this treatment to the standard treatment of 6-8 cycles of chemotherapy," added Professor Illidge.
INFORMATION: END
Scientists explore promising new option for first line of attack in lymphoma
A study led by Manchester scientists has shown promising results for a new treatment approach in follicular lymphoma
2014-02-25
ELSE PRESS RELEASES FROM THIS DATE:
Tumors 'light up' with new, unique imaging system using scorpion venom protein and a laser
2014-02-25
LOS ANGELES (Feb. 24, 2014) – Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery have developed a unique, compact, relatively inexpensive imaging device to "light up" malignant brain tumors and other cancers.
The experimental system consists of a special camera designed and developed at Cedars-Sinai and a new, targeted imaging agent based on a synthetic version of a small protein – a peptide – found in the venom of the deathstalker scorpion. The imaging agent, Tumor Paint BLZ-100, a product of Blaze Bioscience Inc., homes ...
Real time forecast of Hurricane Sandy had track and intensity accuracy
2014-02-25
A real-time hurricane analysis and prediction system that effectively incorporates airborne Doppler radar information may accurately track the path, intensity and wind force in a hurricane, according to Penn State meteorologists. This system can also identify the sources of forecast uncertainty.
"For this particular study aircraft-based Doppler radar information was ingested into the system," said Fuqing Zhang, professor of meteorology, Penn State. "Our predictions were comparable to or better than those made by operational global models."
Zhang and Erin B. Munsell, ...
The only top 10 cancer where survival rates are falling
2014-02-25
Of the top 10 cancers in the UK, bladder cancer is only one where survival rates have been shown to be getting worse. New figures published this month in the Journal of Clinical Urology confirm in a study of cases of bladder cancer in England over a 19 year period (from 1990 until 2009) that survival rates here in the UK are falling and are worse than in than in other European countries with similar incidence rates.
Shockingly, bladder cancer isn't a rare cancer that only affects a few people every year. In fact, bladder cancer is our 7th most common cancer (the 4th most ...
Study shows mentally ill more likely to be victims, not perpetrators, of violence
2014-02-25
New research shows that almost one-third of adults with mental illness are likely to be victims of violence within a six-month period, and that adults with mental illness who commit violence are most likely to do so in residential settings. The study also finds a strong correlation between being a victim of violence and committing a violent act.
The work was done by researchers at North Carolina State University; RTI International; the University of California, Davis; Simon Fraser University; and Duke University.
"We hear about the link between violence and mental illness ...
Anti-vaccine conspiracy theories may have 'detrimental consequences' for children's health
2014-02-25
A belief in anti-vaccine conspiracy theories may have significant and detrimental consequences for children's health, new research from the University of Kent has shown.
Researchers Daniel Jolley and Dr Karen Douglas, of the University's School of Psychology, surveyed 89 parents about their views on anti-vaccine conspiracy theories and then asked them to indicate their intention to have a fictional child vaccinated. It was found that stronger belief in anti-vaccine conspiracy theories was associated with lower intention to vaccinate.
In a second study, 188 participants ...
It's all water over the dam -- but how and when it falls has huge impact on salmon
2014-02-25
RICHLAND, Wash. – By adjusting water discharges in ways designed to boost salmon productivity, officials at a dam in central Washington were able to more than triple the numbers of juvenile salmon downstream of the dam over a 30-year period, according to a study published Feb. 25 in the Canadian Journal of Fisheries and Aquatic Sciences.
"This is one of the most productive populations of fall Chinook salmon anywhere in the Pacific Northwest," said Ryan Harnish, first author of the paper and a fish ecologist at the Department of Energy's Pacific Northwest National Laboratory. ...
Teenage girl suffers second-degree burns in iPhone fire
2014-02-25
Teenage girl suffers second-degree burns in iPhone fire
Article provided by Miller Schirger LLC
Visit us at http://www.millerschirger.com
A 13-year-old girl was treated for second-degree burns recently after her smartphone caught fire in her pocket while she was sitting in school. Although the exact cause of the fire has not yet been determined, some commentators have speculated that it may have been due to a dangerous defect in the phone itself.
A popping sound, then smoke
According to a report by PCMag, the eighth-grader was carrying the two-month-old iPhone ...
The Texas bad faith insurance claim
2014-02-25
The Texas bad faith insurance claim
Article provided by Kustoff & Phipps, L.L.P.
Visit us at http://www.kplegal.com
Insurance permeates many aspects of our lives. At a minimum, most Texans have health, house or renter, car and life insurance. Long-term care insurance pays for nursing home and similar care. Malpractice or professional liability insurance protects professionals against claims of negligent or reckless professional conduct. Most business owners need liability, property, business interruption coverage, and more depending on the unique needs of their ...
Texas Attorney General challenges court's overturning sex crime law
2014-02-25
Texas Attorney General challenges court's overturning sex crime law
Article provided by Law Office of Larry P. McDougal
Visit us at http://www.larrymcdougal.com
Courts in Texas recently decided to strike down a law that addressed online chatting in certain situations. The law banned online chatting between adults and minors that was deemed sexually explicit. Those opposed to the law argued it was a violation of free-speech rights, and the court unanimously agreed.
The state's attorney general is challenging this ruling, leading to a type of "legal turf war" ...
Landlord may be liable for trampoline and swimming pool accident
2014-02-25
Landlord may be liable for trampoline and swimming pool accident
Article provided by Law Offices of Aleixo and Murray, P.C.
Visit us at http://www.aleixoandmurray.com
Under "premises liability" law, the owner of land may be held liable under certain circumstances for injuries that are caused by dangerous conditions on the property. While this liability generally does not extend to open and obvious dangers, a property owner may still be found liable where the landowner should have anticipated that the dangerous condition could cause physical harm, even ...
LAST 30 PRESS RELEASES:
Scientists show how to predict world’s deadly scorpion hotspots
ASU researchers to lead AAAS panel on water insecurity in the United States
ASU professor Anne Stone to present at AAAS Conference in Phoenix on ancient origins of modern disease
Proposals for exploring viruses and skin as the next experimental quantum frontiers share US$30,000 science award
ASU researchers showcase scalable tech solutions for older adults living alone with cognitive decline at AAAS 2026
Scientists identify smooth regional trends in fruit fly survival strategies
Antipathy toward snakes? Your parents likely talked you into that at an early age
Sylvester Cancer Tip Sheet for Feb. 2026
Online exposure to medical misinformation concentrated among older adults
Telehealth improves access to genetic services for adult survivors of childhood cancers
Outdated mortality benchmarks risk missing early signs of famine and delay recognizing mass starvation
Newly discovered bacterium converts carbon dioxide into chemicals using electricity
Flipping and reversing mini-proteins could improve disease treatment
Scientists reveal major hidden source of atmospheric nitrogen pollution in fragile lake basin
Biochar emerges as a powerful tool for soil carbon neutrality and climate mitigation
Tiny cell messengers show big promise for safer protein and gene delivery
AMS releases statement regarding the decision to rescind EPA’s 2009 Endangerment Finding
Parents’ alcohol and drug use influences their children’s consumption, research shows
Modular assembly of chiral nitrogen-bridged rings achieved by palladium-catalyzed diastereoselective and enantioselective cascade cyclization reactions
Promoting civic engagement
AMS Science Preview: Hurricane slowdown, school snow days
Deforestation in the Amazon raises the surface temperature by 3 °C during the dry season
Model more accurately maps the impact of frost on corn crops
How did humans develop sharp vision? Lab-grown retinas show likely answer
Sour grapes? Taste, experience of sour foods depends on individual consumer
At AAAS, professor Krystal Tsosie argues the future of science must be Indigenous-led
From the lab to the living room: Decoding Parkinson’s patients movements in the real world
Research advances in porous materials, as highlighted in the 2025 Nobel Prize in Chemistry
Sally C. Morton, executive vice president of ASU Knowledge Enterprise, presents a bold and practical framework for moving research from discovery to real-world impact
Biochemical parameters in patients with diabetic nephropathy versus individuals with diabetes alone, non-diabetic nephropathy, and healthy controls
[Press-News.org] Scientists explore promising new option for first line of attack in lymphomaA study led by Manchester scientists has shown promising results for a new treatment approach in follicular lymphoma