Tissue repair drug helps heal diabetic foot ulcers

Study first to find a drug can improve healing rates in people at risk for amputation

2014-02-25

(Press-News.org) Washington, DC—Patients were twice as likely to have a diabetic foot ulcer heal within eight weeks when they were treated with a tissue repair drug versus a placebo, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Foot ulcers are a common complication from diabetes than can lead to hospitalization and lower limb amputation. In 2006, about 65,700 non-traumatic lower-limb amputations were performed in people with diabetes, according to the Centers for Disease Control and Prevention. Up to 85 percent of amputations can be avoided when ulcers are prevented from forming or are treated successfully, said one of the study's authors, Francesco Squadrito, MD, of the University of Messina in Gazzi Messina, Italy.

"Foot ulcers are a dangerous and expensive complication for people with diabetes, and current treatments such as hyperbaric oxygen therapy are costly and can have side effects," Squadrito said. "Our study showed for the first time that a pharmacological approach can improve wound healing in people with diabetes."

In the prospective randomized, double-blinded, placebo-controlled clinical trial, 216 participants with diabetic foot ulcers free of visible infection were assigned to receive either the tissue repair drug polydeoxyribonucleotide (PDRN) or a placebo. Participants received injections of either PDRN or a placebo for eight weeks and were monitored for an additional four weeks for any change in the ulcer.

After two months, 37 percent of the patients who were treated with PDRN had their ulcers completely closed, compared with nearly 19 percent of the patients who received the placebo. Study subjects reported few side effects from PDRN, Squadrito said.

"This approach could revolutionize the treatment of diabetic foot ulcers – a main cause of hospital admissions in the developed world," he said. "An estimated 382 million people worldwide have diabetes, and it is crucial to find effective treatment options for hard-to-heal ulcers and other complications facing millions of patients."

INFORMATION: Other authors of the study include: A. Bitto, D. Altavilla, V. Arcoraci, G. De Caridi, G. Pallio, C. Sterrantino, L. Minutoli, A. Saitta, M. Vaccaro and D. Cucinotta of the University of Messina; M. E. De Feo of Cardarelli Hospital in Naples, Italy; and S. Corrao of the University of Palermo in Italy.

The study, "The Effect of PDRN, An Adenosine Receptor A2A Agonist, on the Healing of Chronic Diabetic Foot Ulcers: Results of a Clinical Trial," was published online, ahead of print.

Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 17,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

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Tissue repair drug helps heal diabetic foot ulcers

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