(Press-News.org) The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. Dr. Ying Zhang and co-workers from Guang'anmen Hospital, China Academy of Chinese Medical Sciences in China This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder. Kaixin Jieyu Fang was made from two prescriptions of Kaixin San and Sini San supplemented with Radix Morindae Offcinalis, consisting of eight Chinese herbs including Radix Ginseng, Radix Bupleuri, Fructus Aurantii Immaturus, Radix Morindae Officinalis, Poria, Radix Polygalae, Radix Paeoniae Rubra and Radix Glycytthizae. After treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results, published in the Neural Regeneration Research (Vol. 9, No. 1, 2014), indicate that Kaixin Jieyu Fang can alleviate cerebral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.
INFORMATION:
Article: "Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage," by Ying Zhang, Shijing Huang, Yanyun Wang, Junhua Pan, Jun Zheng, Xianhui Zhang, Yuxia Chen, Duojiao Li (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China)
Zhang Y, Huang SJ, Wang YY, Pan JH, Zheng J, Zhang XH, Chen YX, Li DJ. Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage. Neural Regen Res. 2014;9(1):61-68.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Kaixin Jieyu Fang for treatment of vascular depression
2014-03-27
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Despatch from the field
2014-03-27
Researchers and the public can now have immediate access to data underlying discovery of new species of life on Earth, under a new streamlined system linking taxonomic research with open data publication.
The partnership paves the way for unlocking and preserving a wealth of 'small data' backing up research conclusions, which often become lost within a few years of an article's publication in an academic journal.
In the first example of the new collaboration in action, the Biodiversity Data Journal carries a peer-reviewed description of a new species of spider discovered ...
Acupuncture enhances antidepressant effect of Seroxat
2014-03-27
Acupuncture is more effective than oral antidepressants in improving depressive symptoms, and produces fewer side effects than tricyclic antidepressants. Despite the continued development of antidepressants and alternative/synergistic therapies, major depressive disorder has not been comprehensively recognized and treatment outcome is often insufficient. An epidemiological study addressing depression showed that poor recognition and treatment are largely linked to the lack of an accurate assessment tool and to patients' economic situation. Prof. Yong Huang and team from ...
Hormone levels linked to survival of deer calves, study suggests
2014-03-27
Levels of a key hormone in the blood may be important for the survival prospects of newborn animals, a study of wild deer suggests.
First-born male deer that have relatively high levels of the male hormone testosterone are less likely to survive their first year compared with their peers, the research shows.
Scientists say their findings suggest that high testosterone levels represent a risk to newborns which, when coupled with a new mother's inexperience, lowers their chances of survival.
High levels of testosterone in adult male animals, including deer, are known ...
Ultra-thin light detectors
2014-03-27
This news release is available in German. Subtle interactions of electrons and light make them so valuable for technology: ultra-thin systems of semiconductor layers can turn electrical voltage into light. But they can also be used the other way around and serve as light detectors. Until now, it has been hard to couple light into these layered semiconductor systems. Scientists at Vienna University of Technology solved this problem. They used metamaterials, which are able to manipulate light in the terahertz range due to their special microscopic structure.
Customized ...
Simple blood test may predict if a child will become obese
2014-03-27
Researchers at the Universities of Southampton, Plymouth and Exeter used the test to assess the levels of epigenetic switches in the PGC1a gene – a gene that regulates fat storage in the body.
Epigenetic switches take place through a chemical change called DNA methylation, which controls how genes work and is set during early life.
The Southampton team found that the test, when carried out on children at five years old, differentiates between children with a high body fat and those with a low body fat when they were older. Results showed that a rise in DNA methylation ...
Predicting oil changes in industrial applications without interrupting operations
2014-03-27
This news release is available in German.
Predictive maintenance of hard-to-access plants, no unnecessary oil changes, no unnecessary laboratory costs and less environmental impact. These are just some of the benefits offered by a new system that can monitor the condition of lubricating oils, hydraulic oils and other fluids in industrial installations without interrupting ongoing operations. The method was developed by engineers from Saarbrücken in collaboration with project partners. The compact sensor system is available as a portable unit or can be built into ...
Democratizing data visualization
2014-03-27
In 2007, members of the Haystack Group in MIT's Computer Science and Artificial Intelligence Laboratory released a set of Web development tools called "Exhibit." Exhibit lets novices quickly put together interactive data visualizations, such as maps with sortable data embedded in them; sortable tables that automatically pull in updated data from other sites; and sortable displays of linked thumbnail images.
In April, at the Association for Computing Machinery's Conference on Human Factors in Computing Systems, Haystack members will present an in-depth study of the ways ...
Students on field course bag new spider species
2014-03-27
As a spin-off (pun intended) of their Tropical Biodiversity course in Malaysian Borneo, a team of biology students discover a new spider species, build a makeshift taxonomy lab, write a joint publication and send it off to a major taxonomic journal.
Discovering a new spider species was not what she had anticipated when she signed up for her field course in Tropical Biodiversity, says Elisa Panjang, a Malaysian master's student from Universiti Malaysia Sabah. She is one of twenty students following the course, organised by Naturalis Biodiversity Center in The Netherlands, ...
The first insects were not yet able to smell well
2014-03-27
This news release is available in German. An insect's sense of smell is vital to its survival. Only if it can trace even tiny amounts of odor molecules is it is able to find food sources, communicate with conspecifics, or avoid enemies. According to scientists at the Max Planck Institute for Chemical Ecology in Jena, Germany, many proteins involved in the highly sensitive odor perception of insects emerged rather late in the evolutionary process. The very complex olfactory system of modern insects is therefore not an adaptation to a terrestrial environment when ancient ...
One gene, many tissues
2014-03-27
Genes are the "code" for building the biological elements that form an organism. The DNA that makes up genes contains the instructions to synthesise proteins, but it's wrong to think that, for a given gene, these instructions are always the same for all parts of the organisms. In actual fact, the gene varies depending on the tissue where it is located (cerebral cortex, cerebellum, olfactory epithelium, etc.); in particular, what varies is the point in the "string" of code at which protein synthesis starts. This complexity complicates the work of scientists considerably, ...