Citizens help researchers to challenge scientific theory

(Press-News.org) Science crowdsourcing was used to disprove a widely held theory that "supertasters" owe their special sensitivity to bitter tastes to an usually high density of taste buds on their tongue, according to a study published in the open-access journal Frontiers in Integrative Neuroscience.

Supertasters are people who can detect and are extremely sensitive to phenylthiocarbamide and propylthiouracil, two compounds related to the bitter molecules in certain foods such as broccoli and kale. Supertasting has been used to explain why some people don't like spicy foods or "hoppy" beers, or why some kids are picky eaters.

The sensitivity to these bitter tastants is partly due to a variation in the taste receptor gene TAS2R38. But some scientists believe that the ability to supertaste is also boosted by a greater-than-average number of "papillae", bumps on the tongue that contain taste buds. Nicole Garneau, Curator and Chair of the Department of Health Sciences, Denver Museum of Nature & Science, and colleagues tested if this is true.

"There is a long-held belief that if you stick out your tongue and look at the bumps on it, then you can predict how sensitive you are to strong tastes like bitterness in vegetables and strong sensations like spiciness," says Garneau. "The commonly accepted theory has been that the more bumps you have, the more taste buds you have and therefore the more sensitive you are."

Over 3000 visitors to the museum's Genetics of Taste Lab volunteered to stick their tongue out so that their papillae could be counted and their sensitivity to phenylthiocarbamide and propylthiouracil measured. In total, 394 study subjects were included in the analysis. Cell swabs from volunteers were taken to determine their DNA sequence at TAS2R38. Results confirmed that certain variations in TAS2R38 make it more likely that somebody is sensitive to bitter, but also proved that the number of papillae on the tongue does not affect increased taste sensitivity.

"No matter how we looked at the data, we couldn't replicate this long held assumption that a high number of papillae equals supertasting," says Garneau.

The authors argue against the continued misuse of the term supertaster, and for the use of the more objective term hypergeusia – abnormally sensitized taste – to describe people who are sensitive to all tastes and sensations from food.

"What we know and understand about how our bodies work improves greatly when we challenge central dogmas of our knowledge. This is the nature of science itself," adds Garneau. "As techniques improve, so too does our ability to do science, and we find that what we accepted as truth 20, 30, or 100 years ago gets replaced with better theories as we gather new data, which advances science. In this case, we've proven that with the 'Denver Papillae Protocol', our new method for objective analysis for papillae density, we were unable to replicate well-known studies about supertasting."

What make this study unique is that most of the results were collected by citizen scientists including over 130 volunteers who had been specially trained by Garneau and her colleagues. The Genetics of Taste Lab is located in the heart of the museum, uniquely situated to attract volunteers and dedicated citizen scientists who conduct population-based research about human genetics, taste, and health.

INFORMATION: Note to Editors

1. For a copy of the embargoed paper, please contact Gozde Zorlu: press@frontiersin.org

2. Article title: Crowdsourcing taste research: genetic and phenotypic predictors of bitter taste perception as a model

Journal: Frontiers in Integrative Neuroscience

For online articles, please include a link to the paper, which will appear on the following active URL: http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00033/full

3. Contacts Gozde Zorlu
Communications Manager
Frontiers
Switzerland
E-mail: press@frontiersin.org

Maura O'Neal
Communications and Media Relations Manager
Denver Museum of Nature & Science
E-mail: Maura.oneal@dmns.org

4. About Frontiers Frontiers is a community-driven open-access publisher and research networking platform. Launched and run by scientists since 2007, Frontiers empowers researchers to advance the way science is peer-reviewed, evaluated, published, communicated, and shared in the digital era. Frontiers drives innovations in peer-review, article level metrics, post publication review, democratic evaluation, research networking and a growing ecosystem of open-science tools. Frontiers joined the Nature Publishing Group family in 2013. The "Frontiers In" journal series has published 20,000 peer-reviewed articles across 45 journals, which receive 6 million monthly views, and are supported by over 140,000 editors, reviewers and authors worldwide.