PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Antioxidant biomaterial promotes healing

Northwestern University professor Guillermo Ameer's antioxidant biomaterial helps vascular grafts heal

2014-07-24
(Press-News.org) When a foreign material like a medical device or surgical implant is put inside the human body, the body always responds. According to Northwestern University's Guillermo Ameer, most of the time, that response can be negative and affect the device's function.

"You will always get an inflammatory response to some degree," said Ameer, professor of biomedical engineering in Northwestern's McCormick School of Engineering and Applied Science and professor of surgery in the Feinberg School of Medicine. "A problem with commonly used plastic materials, in particular, is that in addition to that inflammatory response, oxidation occurs."

We all need oxygen to survive, but a high concentration of oxygen in the body can cause oxidative reactions to fall out of balance, which modifies natural proteins, cells, and lipids and causes them to function abnormally. This oxidative stress is toxic and can contribute to chronic disease, chronic inflammation, and other complications that may cause the failure of implants.

For the first time ever, Ameer and his team have created a biodegradable biomaterial that is inherently antioxidant. The material can be used to create elastomers, liquids that turn into gels, or solids for building devices that are more compatible with cells and tissues. The research is described in the June 26 issue of Biomaterials.

"Plastics can self-oxidize, creating radicals as part of their degradation process," Ameer said. "By implanting devices made from plastics, the oxidation process can injure nearby cells and create a cascade that leads to chronic inflammation. Our materials could significantly reduce the inflammatory response that we typically see."

Ameer created the biomaterial, which is a polyester based on citric acid, by incorporating vitamin C as part of the building blocks. In preliminary experiments, his team coated vascular grafts with the antioxidant biomaterial, and the grafts were evaluated in animals by Ameer's long-time collaborator Melina Kibbe, professor of surgery and the Edward G. Elcock Professor of Surgical Research at Feinberg and a vascular surgeon at Northwestern Memorial Hospital.

As part of the foreign body response, grafts tend to inflame nearby cells and slowly scar over time, which eventually leads to failure. When the antioxidant vascular graft was implanted, however, the scarring was significantly reduced. Ameer's team, funded by a proof-of-concept grant from the Northwestern University Clinical and Translational Sciences Institute, also found that a water-soluble, thermoreversible version of the material sped of the healing of diabetic ulcers. Because the material is biodegradable, it harmlessly is absorbed by the body over time.

"In the past, people have added antioxidant vitamins to a polymer and blended it in," Ameer said. "That can affect the mechanical properties of the material and limit how much antioxidant you can add, so it doesn't work well. What we're doing is different. We're building a material that is already inherently, intrinsically antioxidant."

Ameer said the new biomaterial could be used to create scaffolds for tissue engineering, coat or build safer medical devices, promote healing in regenerative medicine, and protect cells, genes, and viruses during drug delivery. He added that the new biomaterial is easy to make and inexpensive.

"Citric acid is affordable and in pretty much everything we come in contact with on a daily basis—food and beverages, skin and hair products, drugs, etc.," Ameer said. "It's a common, inexpensive raw material to use, and our system can stabilize vitamin C, an antioxidant that we are all familiar with."

INFORMATION: The first author of the study was Robert van Lith, a PhD candidate in Ameer's research laboratory.


ELSE PRESS RELEASES FROM THIS DATE:

Moose drool inhibits growth of toxic fungus: York U research

Moose drool inhibits growth of toxic fungus: York U research
2014-07-24
TORONTO, June 24, 2014 – Some sticky research out of York University shows a surprisingly effective way to fight against a certain species of toxic grass fungus: moose saliva (yes… moose saliva). Published in this month's Biology Letters, "Ungulate saliva inhibits a grass–endophyte mutualism" shows that moose and reindeer saliva, when applied to red fescue grass (which hosts a fungus called epichloë festucae that produces the toxin ergovaline) results in slower fungus growth and less toxicity. "Plants have evolved defense mechanisms to protect themselves, such as thorns, ...

Study shows role of media in sharing life events

2014-07-24
MADISON — To share is human. And the means to share personal news — good and bad — have exploded over the last decade, particularly social media and texting. But until now, all research about what is known as "social sharing," or the act of telling others about the important events in our lives, has been restricted to face-to-face interactions. A new study, published in the current issue of the journal Computers in Human Behavior, investigates what happens when people share via new media. What media do people choose for sharing their important personal events? How ...

Election surprises tend to erode trust in government

2014-07-24
Athens, Ga. – When asked who is going to win an election, people tend to predict their own candidate will come out on top. When that doesn't happen, according to a new study from the University of Georgia, these "surprised losers" often have less trust in government and democracy. And the news media may be partly to blame, according to Barry Hollander, author of the study and UGA professor in the Grady College of Journalism and Mass Communication. "You need the trust of those in a democracy for democracy to be successful," said Hollander. "We have become more fragmented ...

Link between ritual circumcision procedure and herpes infection in infants examined

2014-07-24
PHILADELPHA—A rare procedure occasionally performed during Jewish circumcisions that involves direct oral suction is a likely source of herpes simplex virus type 1 (HSV-1) transmissions documented in infants between 1988 and 2012, a literature review conducted by Penn Medicine researchers and published online in the Journal of the Pediatric Infectious Disease Society found. The reviewers, from Penn's Center for Evidence-based Practice, identified 30 reported cases in New York, Canada and Israel. The practice—known as metzitzah b'peh—and its link to HSV-1 infections ...

Penn study: Incisionless transcatheter aortic valve replacement surgery cuts hospital length of stay

2014-07-24
PHILADELPHIA – New research from Penn Medicine shows that incisionless transcatheter aortic valve replacement (TAVR) surgery cuts length of hospital stay by 30 percent and has no impact on post-operative vascular complication rates when compared with conventional transfemoral TAVR, which requires an incision in the groin. The complete study is available in the current issue of Circulation: Cardiovascular Interventions. TAVR involves the replacement of the aortic valve without a traditional open-heart surgical approach. It is a treatment for aortic stenosis, a narrowing ...

Piggy-backing cells hold clue to skin cancer growth

2014-07-24
Skin Cancer cells work together to spread further and faster, according to a new study published in Cell Reports. The discovery could lead to new drugs to tackle melanoma, the most deadly form of skin cancer. Cancer Research UK scientists at The University of Manchester found that some melanoma cells are particularly fast growing, but not very good at invading the surrounding tissue, while other melanoma cells are the opposite – highly invasive but slow-growing. In a tumour, the faster growing cells 'piggy-back' along with the more invasive cells, so together they ...

Rutgers study explores attitudes, preferences toward post-Sandy rebuilding

2014-07-24
NEW BRUNSWICK, N.J. – A yearlong study funded by the New Jersey Recovery Fund and conducted by researchers at the Edward J. Bloustein School of Planning and Public Policy at Rutgers University has found that individual property owners in Sandy-affected towns are skeptical about the likelihood of community-based rebuilding solutions. Of the more than 400 online survey respondents, 45 percent indicated they were "pessimistic" or "very pessimistic" that the parts of their town affected by Superstorm Sandy would be rebuilt better than they were before the storm; another 24 ...

Joblessness could kill you, but recessions could be good for your health

Joblessness could kill you, but recessions could be good for your health
2014-07-24
Being unemployed increases your risk of death, but recessions decrease it. Sound paradoxical? Researchers thought so too. While previous studies of individuals have shown that employees who lose their jobs have a higher mortality rate, more comprehensive studies have shown, unexpectedly, that population mortality actually declines as unemployment rates increase. Researchers from Drexel University and the University of Michigan in Ann Arbor set out to better understand these seemingly contradictory findings. Using a nationally representative panel of individuals across ...

Artificial intelligence identifies the musical progression of the Beatles

2014-07-24
Music fans and critics know that the music of the Beatles underwent a dramatic transformation in just a few years, but until now there hasn't been a scientific way to measure the progression. That could change now that computer scientists at Lawrence Technological University have developed an artificial intelligence algorithm that can analyze and compare musical styles, enabling research into the musical progression of the Beatles. Assistant Professor Lior Shamir and graduate student Joe George had previously developed audio analysis technology to study the vocal communication ...

Early warning sign for babies at risk of autism

2014-07-24
CORAL GABLES, Fla. (July 24, 2014) -- Some babies are at risk for autism because they have an older sibling that has the disorder. To find new ways to detect Autism Spectrum Disorder (ASD) earlier in life, researchers are exploring the subtleties of babies' interactions with others and how they relate to the possibility and severity of future symptoms. A new study helps us to understand the connection between early joint attention before one year and later ASD symptoms. Joint attention is an early form of communication that develops toward the end of the first year. ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Antioxidant biomaterial promotes healing
Northwestern University professor Guillermo Ameer's antioxidant biomaterial helps vascular grafts heal