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Vacuum treatment may limit damage after traumatic brain injury

'Mechanical tissue resuscitation' reduces tissue injury and bleeding in animal model, reports study in Neurosurgery

2014-07-31
(Press-News.org) July 31, 2014 – Controlled application of vacuum pressure is a promising approach to limiting tissue damage after traumatic brain injury (TBI), suggests an experimental study in the August issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

"Mechanical tissue resuscitation"—consisting of vacuum pressure applied over the injured area of the brain—shows promise as a safe and effective treatment for TBI, according to the research report by Dr. Louis C. Argenta and Dr. Michael Morykwas and co investigators of Wake Forest University of Health Sciences, Winston-Salem, N.C. However, the technique needs further development before it can be studied in humans with TBI.

Could Vacuum Pressure Mitigate Damage after TBI? In the study, which was funded by a major grant from the U.S. Army, the researchers tested the mechanical tissue resuscitation approach by inducing localized TBI in swine, then applying negative pressure—that is, a mild vacuum—over the injured area of the brain. The study evaluated the effects of different levels of pressure, 50 or 100 millimeters of mercury (mm Hg); different application times, three or five days; and different delay times, up to six hours.

The results showed important benefits of applying vacuum pressure after brain injury. Applying 100 mm Hg of pressure for three days led to a significantly smaller area of brain contusion and reduced bleeding, compared to no pressure or 50 mm Hg of pressure. Brain MRI scans showed a more-normal appearance in vacuum-treated animals, which was confirmed by later examination of the brain tissues.

All animals survived after five days of vacuum application, whereas half of animals died when treatment was stopped after three days. The response to vacuum pressure was about the same when treatment was delayed for three hours, compared to no delay. The procedure appeared safe, without the development of seizures or brain deformation. Traumatic brain injury is a devastating problem, with high rates of death and disability and limited treatment options. Following TBI, impaired circulation and accumulation of metabolites and water in the area of injury lead to progressive secondary injury and neuronal (brain cell) degeneration.

The new technique evolved from the successful use of negative pressure to promote healing in other types of wounds. In previous studies, Drs. Argenta and Morykwas and colleagues found benefits of controlled vacuum application to localized areas of TBI in rats. In the new study, they sought to evaluate the safety and effectiveness of this mechanical tissue resuscitation technique in a large-animal model more similar to the human brain with TBI.

"The ability of mechanical tissue resuscitation to achieve meaningful reduction in loss of brain tissue and hemorrhage injury warrants further investigation," the researchers conclude. It's unclear exactly how mechanical tissue resuscitation might work to reduce the area of tissue damage after TBI—it may act by increasing blood flow to the injured tissue, thus promoting oxygenation, nutrient supply, and removal of waste products.

Since the effects of vacuum treatment are "purely mechanical," it might be useful in combination with other treatments, Drs. Argenta and Morykwas and coauthors believe. They're performing further studies to optimize the mechanical tissue resuscitation technique before initial trials in human patients with TBI.

INFORMATION: Click here to read "Mechanical Tissue Resuscitation at the Site of Traumatic Brain Injuries Reduces the Volume of Injury and Hemorrhage in a Swine Model."

About Neurosurgery Neurosurgery, the Official Journal of the Congress of Neurological Surgeons, is your most complete window to the contemporary field of neurosurgery. Members of the Congress and non-member subscribers receive 3,000 pages per year packed with the very latest science, technology, and medicine, not to mention full-text online access to the world's most complete, up-to-the-minute neurosurgery resource. For professionals aware of the rapid pace of developments in the field, Neurosurgery is nothing short of indispensable.

About Wolters Kluwer Health Wolters Kluwer Health is a leading global provider of information, business intelligence and point-of-care solutions for the healthcare industry. Serving more than 150 countries worldwide, clinicians rely on Wolters Kluwer Health's market leading information-enabled tools and software solutions throughout their professional careers from training to research to practice. Major brands include Health Language®, Lexicomp®, Lippincott Williams & Wilkins, Medicom®, Medknow, Ovid®, Pharmacy OneSource®, ProVation® Medical and UpToDate®.

Wolters Kluwer Health is part of Wolters Kluwer, a market-leading global information services company. Wolters Kluwer had 2013 annual revenues of €3.6 billion ($4.7 billion), employs approximately 19,000 people worldwide, and maintains operations in over 40 countries across Europe, North America, Asia Pacific, and Latin America. Follow our official Twitter handle: @WKHealth.


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[Press-News.org] Vacuum treatment may limit damage after traumatic brain injury
'Mechanical tissue resuscitation' reduces tissue injury and bleeding in animal model, reports study in Neurosurgery