PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Age and diabetes duration linked to risk of death and macrovascular complications

But only diabetes duration linked to risk of microvascular complications

2014-09-12
(Press-News.org) New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that age (or age at diagnosis) and duration of diabetes disease are linked to the risk of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in the eyes). This means younger people with diabetes are more at risk of microvascular complications since they are more likely to have diabetes for longer over their lifetimes than those diagnosed at an older age, and should be targeted for more intensive interventions to help control their blood sugar. The research is by Associate Professor Sophia Zoungas, The George Institute for Global Health, University of Sydney, NSW, Australia, and Professor Simon Heller, University of Sheffield, UK, and colleagues.

Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications. To investigate this, the authors conducted a study involving participants of Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Re-lease Controlled Evaluation (ADVANCE) trial (published in The Lancet in 2007 and the New England Journal of Medicine in 2008), with its cohort described by the authors as being generally representative of people with diabetes in developed countries such as Australia, New Zealand, China and nations of Europe, and also including China, a developing country. The associations between age (or age at diagnosis), diabetes duration and major macrovascular events, all-cause death and major microvascular events were examined in 11,140 patients with type 2 diabetes randomly allocated to intensive or standard glucose control in this study.

The researchers found that the mean age of participants was 66 years, age at diagnosis was 59 years and diabetes duration was 8 years. For each 5 year increase in age (or age at diagnosis), the multiple adjusted risks of macrovascular events and all-cause death were increased by 33% and 56%, respectively. For each 5 year increase in duration of diabetes, the risks of macrovascular events and all-cause death were increased by 13% and 15%, respectively, when accounting for age, or increased by 49% and 78%, respectively, when accounting for age at diagnosis. The authors explain that this difference is due to the fact that age has a much greater effect than age at diagnosis on the risk of cardiovascular events and death. "Thus the impact of duration of diabetes on these risks is less if we account for age as compared to age at diagnosis of diabetes," they say. With regard to microvascular complications, the authors say that "a refocus towards intensive management of hyperglycaemia at diagnosis, particularly in younger people, may be warranted if the long-term risk of microvascular complications is to be minimised. With the increasing number of non-pharmacological and pharmacological approaches to improve glycaemic control this objective should be achievable."

They add: "With respect to macrovascular complications, our findings from patients with type 2 diabetes indicate that effective prevention requires vigilance at all stages of the disease and across all age groups. However, as the absolute event rates were highest in the older age groups, surveillance for macrovascular complications should be intensified with increasing age."

They conclude: "In patients with type 2 diabetes, age or age at diagnosis of diabetes and diabetes duration are independently associated with the risk of macrovascular complications and death. By contrast, only diabetes duration is independently associated with the risk of microvascular complications, and the effects of diabetes duration are greatest at younger rather than older ages. Intensive glycaemic control of young people diagnosed with type 2 diabetes is warranted early to minimise the risk of microvascular complications."

INFORMATION: END


ELSE PRESS RELEASES FROM THIS DATE:

The Lancet: Combining gut hormone with insulin proves more effective at controlling type 2 diabetes than other common treatments

2014-09-12
Combined treatment with a drug that mimics the action of a gut hormone and basal insulin [1] is more effective at improving blood sugar control than other anti-diabetic treatments, with similar rates of hypoglycaemia (dangerously low blood sugar levels) and greater weight loss, a systematic review and meta-analysis published in The Lancet shows. "Achieving normal blood sugar levels in people with type 2 diabetes is compromised by the adverse side effects plaguing currently available treatments. Some anti-diabetic treatments increase risk of hypoglycaemia and weight gain ...

Many kidney failure patients have concerns about pursuing kidney transplantation

2014-09-12
Washington, DC (September 11, 2014) — Concerns about pursuing kidney transplantation are highly prevalent among kidney failure patients, particularly older adults and women, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). Reducing these concerns may help decrease disparities in access to transplantation. There are thousands of patients with kidney failure who lack access to kidney transplantation, and disparities persist in terms of race, age, sex, and other patient characteristics. To improve ...

Microbes evolve faster than ocean can disperse them

Microbes evolve faster than ocean can disperse them
2014-09-12
Two Northeastern University researchers and their international colleagues have created an advanced model aimed at exploring the role of neutral evolution in the biogeographic distribution of ocean microbes. Their findings were published Thursday in the journal Science. The paper—titled "Biogeographic patterns in ocean microbes emerge in a neutral agent-based model"—was co-authored by Ferdi Hellweger, a microbial ecology expert and an associate professor of civil and environmental engineering; his doctoral student Neil Fredrick, PhD'15; and oceanographer Erik van Sebille ...

Inflammation may be key to diabetes/heart disease link

2014-09-11
Inflammation may be the reason high blood sugar levels damage blood vessels, raising the possibility that anti-inflammatory medications might someday be used to lower the risk of blood vessel disease in people with diabetes, according to a study presented at the American Heart Association's High Blood Pressure Research Scientific Sessions 2014. "These findings may explain why good blood sugar control is not sufficient to avoid the development of diabetes-induced cardiovascular diseases," said Carlos F. Sánchez-Ferrer, M.D., Ph.D., study author and professor of pharmacology ...

Cutting the cord on soft robots

2014-09-11
When it comes to the development of soft robots, researchers have finally managed to cut the cord. Engineers at Harvard's School for Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering have developed the world's first untethered soft robot – a quadruped which can literally stand up and walk away from its designers. Working in the lab of Charles River Professor of Engineering and Applied Sciences Robert Wood, a team of researchers that included Michael Tolley, Robert Shepherd, Bobak Mosadegh, Kevin Galloway, Michael Wehner ...

NASA research helps unravel mysteries of the Venusian atmosphere

NASA research helps unravel mysteries of the Venusian atmosphere
2014-09-11
VIDEO: New research shows giant holes in Venus' atmosphere -- which serve as extra clues for understanding this planet so different from our own. Click here for more information. Underscoring the vast differences between Earth and its neighbor Venus, new research shows a glimpse of giant holes in the electrically charged layer of the Venusian atmosphere, called the ionosphere. The observations point to a more complicated magnetic environment than previously thought – which ...

Tipping the balance of behavior

Tipping the balance of behavior
2014-09-11
Humans with autism often show a reduced frequency of social interactions and an increased tendency to engage in repetitive solitary behaviors. Autism has also been linked to dysfunction of the amygdala, a brain structure involved in processing emotions. Now Caltech researchers have discovered antagonistic neuron populations in the mouse amygdala that control whether the animal engages in social behaviors or asocial repetitive self-grooming. This discovery may have implications for understanding neural circuit dysfunctions that underlie autism in humans. This discovery, ...

Original northern border of Illinois was south of Chicago and Lake Michigan

Original northern border of Illinois was south of Chicago and Lake Michigan
2014-09-11
URBANA, Ill. – Chicago residents today might have had a Wisconsin zip code if the originally proposed northern boundary of Illinois had been approved. It was a straight line from the southernmost tip of Lake Michigan to just south of the Rock and Mississippi River confluence. University of Illinois soil scientist Ken Olson said that had the proposed northern border not been changed, the state of Illinois would have a much smaller population and footprint with the northern 51 miles of the Illinois Territory ceded to Wisconsin when it became a state in 1848. Olson says ...

Diabetes researchers find faster way to create insulin-producing cells

2014-09-11
University of British Columbia, in collaboration with BetaLogics Venture, a division of Janssen Research & Development, LLC, has published a study highlighting a protocol to convert stem cells into insulin-producing cells. The new procedure could be an important step in the fight against Type 1 diabetes. The protocol can turn stem cells into reliable, insulin-producing cells in about six weeks, far quicker than the four months it took using previous methods. "We are a step closer to having an unlimited supply of insulin-producing cells to treat patents with Type ...

One-minute point-of-care anemia test shows promise in new study

One-minute point-of-care anemia test shows promise in new study
2014-09-11
A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease. The disposable self-testing device analyzes a single droplet of blood using a chemical reagent that produces visible color changes corresponding to different levels of anemia. The basic test produces results in about 60 seconds and requires no electrical power. A companion smartphone application can automatically correlate the visual results to specific blood hemoglobin ...

LAST 30 PRESS RELEASES:

What’s behind the enormous increase in early-onset gastrointestinal cancers?

Pharmacogenomics expert advances precision medicine for bipolar disorder

Brazilian researcher explores centenarian stem cells for aging insights

Dr. Xuyu Qian's breakthrough analysis of 18 million brain cells advances understanding of human brain development

Gene networks decode human brain architecture from health to glioma

How artificial light at night damages brain health and metabolism

For ultrasound, ultra-strength not always a good thing

Matching your workouts to your personality could make exercising more enjoyable and give you better results

Study shows people perceive biodiversity

Personality type can predict which forms of exercise people enjoy

People can accurately judge biodiversity through sight and sound

People diagnosed with dementia are living longer, global study shows

When domesticated rabbits go feral, new morphologies emerge

Rain events could cause major failure of Waikīkī storm drainage by 2050

Breakthrough in upconversion luminescence research: Uncovering the energy back transfer mechanism

Hidden role of 'cell protector' opens cancer treatment possibilities

How plants build the microbiome they need to survive in a tough environment

Depression due to politics and its quiet danger to democracy addressed in new book 'The Sad Citizen'

International experts and patients unite to help ensure all patients are fully informed before consenting to new surgical procedures

Melting glaciers could trigger more explosive eruptions globally, finds research

Nearly half of U.S. grandchildren live within 10 miles of a grandparent

Study demonstrates low-cost method to remove CO₂ from air using cold temperatures, common materials

Masonic Medical Research Institute (MMRI) welcomes 13 students to prestigious Summer Fellowship program

Mass timber could elevate hospital construction

A nuanced model of soil moisture illuminates plant behavior and climate patterns

$2.6 million NIH grant backs search for genetic cure in deadly heart disease

Pennsylvania’s medical cannabis program changed drastically when anxiety was added as a qualifying condition

1 in 5 overweight adults could be reclassified with obesity according to new framework

Findings of study on how illegally manufactured fentanyl enters U.S. contradict common assumptions, undermining efforts to control supply

Satellite observations provide insight into post-wildfire forest recovery

[Press-News.org] Age and diabetes duration linked to risk of death and macrovascular complications
But only diabetes duration linked to risk of microvascular complications