Results of ISAR-CLOSURE trial reported at TCT 2014

Large randomized trial compares use of vascular closure devices to manual compression in patients undergoing transfemoral coronary angiography

2014-09-15

(Press-News.org) WASHINGTON, DC – September 13, 2014 – A new clinical trial found that vascular closure devices (VCD) are non-inferior to manual compression in patients undergoing transfemoral coronary angiography. Findings were reported today at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

Vascular closure devices help achieve more rapid hemostasis after coronary angiography, however the safety and efficacy of these devices compared to standard manual compression remains controversial. Some meta-analyses have suggested an increased risk of vascular complications with VCD compared with manual compression, while other studies have demonstrated a reduction in bleeding complications with VCD.

The ISAR-CLOSURE trial compared outcomes after arteriotomy closure with two different vascular closure devices with manual compression after diagnostic angiography performed through the femoral access route. The multicenter, open-label clinical trial randomized 4,524 patients undergoing diagnostic coronary angiography via the common femoral artery to receive either manual compression (n=1,509) or one of two vascular closure devices (Femoseal VCD n=1,509; Exoseal VCD n= 1,506).

The primary endpoint was vascular access site complications including the composite of hematoma greater than or equal to five centimeters, arterio-venous fistula, pseudoaneurysma, access-site related bleeding, acute ipsilateral leg ischemia, the need for vascular surgical or interventional treatment, and local infection at 30 days after randomization. Secondary endpoints included time to hemostasis, repeat manual compression and device failure. A secondary comparison between the two VCDs was also performed.

After 30 days, the VCD group reported access site complications in 6.9 percent of patients compared to 7.9 percent in the manual compression group, establishing non-inferiority of VCD. The most common complication in both groups was hematoma formation, followed by pseudoaneurym formation. Time to hemostasis was shorter in the VCD group (median 1 minute [.5-2.0] vs. 10 minutes [10-15], p END

ELSE PRESS RELEASES FROM THIS DATE:

International study identifies new genetic variants indicating risk for prostate cancer

2014-09-15

An international study co-led by Keck School of Medicine of the University of Southern California (USC) scientists and researchers in the United Kingdom has revealed 23 new genetic susceptibility locations indicating risk for prostate cancer. The data study, analyzing more than 87,000 individuals of European, African, Japanese and Latino ancestry, is the largest of its kind and is the first that combines multiple studies across different ethnic populations. "The goal of this research is to identify regions of the genome that contribute susceptibility to prostate cancer ...

Contaminated water in 2 states linked to faulty shale gas wells

2014-09-15

DURHAM, N.C. -- Faulty well integrity, not hydraulic fracturing deep underground, is the primary cause of drinking water contamination from shale gas extraction in parts of Pennsylvania and Texas, according to a new study by researchers from five universities. The scientists from Duke, Ohio State, Stanford, Dartmouth and the University of Rochester published their peer-reviewed study Sept. 15 in the Proceedings of the National Academy of Sciences. Using noble gas and hydrocarbon tracers, they analyzed the gas content of more than 130 drinking water wells in the two ...

Gut bacteria tire out T cells

2014-09-15

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Medicine on September 15, may explain why these patients suffer from recurrent bacterial infections. Patients with a disease called common variable immunodeficiency (CVID) suffer from recurrent bacterial infections as a result of faulty immune cells. But despite these immune defects, CVID patients rarely contract viral infections. New data from Matthieu ...

T-bet tackles hepatitis

2014-09-15

A single protein may tip the balance between ridding the body of a dangerous virus and enduring life-long chronic infection, according to a report appearing in The Journal of Experimental Medicine. Hepatitis B and C viruses cause chronic infections in roughly three-quarters of infected people, putting these individuals at risk for developing liver diseases including cirrhosis and cancer. A few patients successfully eliminate infection, thanks primarily to virus-fighting immune cells called CD8+ T cells. The protective effects of CD8+ T cells depend on a cellular protein ...

Gas leaks from faulty wells linked to contamination in some groundwater

2014-09-15

COLUMBUS, Ohio—A study has pinpointed the likely source of most natural gas contamination in drinking-water wells associated with hydraulic fracturing, and it's not the source many people may have feared. What's more, the problem may be fixable: improved construction standards for cement well linings and casings at hydraulic fracturing sites. A team led by a researcher at The Ohio State University and composed of researchers at Duke, Stanford, Dartmouth, and the University of Rochester devised a new method of geochemical forensics to trace how methane migrates under ...

Rice rolls 'neat' nanotube fibers

2014-09-15

The very idea of fibers made of carbon nanotubes is neat, but Rice University scientists are making them neat -- literally. The single-walled carbon nanotubes in new fibers created at Rice line up like a fistful of uncooked spaghetti through a process designed by chemist Angel Martí and his colleagues. The tricky bit, according to Martí, whose lab reported its results this month in the journal ACS Nano, is keeping the densely packed nanotubes apart before they're drawn together into a fiber. Left to their own devices, carbon nanotubes form clumps that are perfectly ...

1 in 5 men reports violence toward intimate partners

2014-09-15

ANN ARBOR, Mich. —One in five men in the U.S. reports violence towards their spouse or significant other, says a new nationally-representative study by the University of Michigan. The analysis also found that male aggression toward a partner is associated with warning signs that could come up during routine health care visits, including irritable bowel syndrome (IBS) and insomnia, in addition to better known risks like substance abuse and a history of either experiencing or witnessing violence as a child. The findings appear in the Journal of the American Board of Family ...

UChicago study finds young women involve parent in abortion when anticipating support

2014-09-15

CHICAGO, IL—When an adolescent wants to terminate a pregnancy, how does she decide whether to talk to a parent? A recent study from the Section of Family Planning and Contraceptive Research at the University of Chicago found that pregnant teens will turn to parents and adults who are engaged in their lives and who will offer support, regardless of her pregnancy decision. Young women will avoid talking with parents who are less involved or may try to prevent them from seeking care. The study, published online ahead of print in the American Journal of Public Health, explored ...

Genetics reveals patients susceptible to drug-induced pancreatitis

2014-09-15

Doctors have discovered that patients with a particular genetic variation are four times more likely to develop pancreatitis if they are prescribed a widely used group of drugs. Clinicians at the Royal Devon and Exeter NHS Foundation Trust and the University of Exeter Medical School have discovered that 17 per cent of patients who have two copies of a particular genetic marker are likely to go on to develop pancreatitis if they are prescribed thiopurine drugs. The drugs, which include azathioprine and mercaptopurine, are some of the most effective and most commonly used ...

Scientists come closer to the industrial synthesis of a material harder than diamond

2014-09-15

Researchers from Moscow Institute of Physics and Technology, Technological Institute for Superhard and Novel Carbon Materials in Troitsk, MISiS, and MSU have developed anew method for the synthesis of an ultrahard material that exceeds diamond in hardness. An article recently published in the journal Carbon describes in detail a method that allows for the synthesis of ultrahard fullerite, a polymer composed of fullerenes, or spherical molecules made of carbon atoms. In their work, the scientists note that diamond hasn't been the hardest material for some time now. Natural ...

Results of ISAR-CLOSURE trial reported at TCT 2014

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: