GLP-1RA switching and treatment persistence in adults without diabetes

JAMA Network Open

2026-03-10

(Press-News.org) About The Study: In this large cohort of adults with overweight or obesity without diabetes, fewer than 1 in 4 patients remained on any glucagon-like peptide-1 receptor agonist (GLP-1RA) after 12 months. Switching between GLP-1RA agents was common and may reflect active therapy management rather than nonengagement, particularly as new formulations and weight management agents emerge.

Corresponding Author: To contact the corresponding author, Luyu Xie, PharmD, PhD, email luyu.xie@utsouthwestern.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2026.1272)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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GLP-1RA switching and treatment persistence in adults without diabetes

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