(Press-News.org) DOWNERS GROVE, Ill. – October 23, 2014 – An international multicenter study reports that over-the-scope clip (OTSC) placement is a safe and effective therapy for the closure of gastrointestinal (GI) defects, which includes anastomotic leaks, fistulae and perforations. Clinical success was best achieved in patients undergoing closure of perforations or leaks when OTSC placement was used for primary or rescue therapy. The overall clinical success for the closure of perforations and leaks ranged between 90 percent and 73 percent; however, successful closure of fistulae was achieved in less than half of the patients. The type of defect (i.e. perforation or leak) is the best predictor of successful long-term closure. The study appears in the October issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).
Conventional treatment of GI defects is with surgical management, which is associated with significant morbidity and mortality. Technological advances in endoscopic devices have allowed for endoscopic closure of GI defects. Endoscopic therapies include placement of self-expandable metal stents (SEMSs) and application of clips and sealants, all of which have proven their utility in different clinical scenarios with varying degrees of success. The most common endoscopic approach for treatment of GI defects before the over-the-scope clip was the use of temporary SEMSs.
A large case series reported a success rate as high as 75 percent with SEMSs; however, this practice was associated with a high rate of adverse events (46 percent). The OTSC provides more durable closure than standard clips because of its wider mouth and ability to grasp larger amounts of tissue. In addition, full-thickness closure is achievable because of greater compressive force. The current study is the largest to-date to assess outcomes of OTSCs in the management of GI fistulae, perforations and leaks.
"The primary goal of this study was to describe a large, international, multicenter experience with OTSCs for the management of GI perforations, fistulae and anastomotic leaks and to determine the overall success of GI defect closure. Secondary goals were to determine success rate by type of defect and type of therapy, primary vs. rescue, and to determine predictors of OTSC success," said study lead author Yamile Haito-Chavez, MD, Johns Hopkins University, Baltimore, Maryland. "Our study found that long-term success was achieved in 60.2 percent of patients. The rate of successful closure of perforations was 90 percent, closure of leaks was 73.3 percent and closure of fistulae was 42.9 percent. Long-term success was significantly higher when OTSCs were applied as a primary therapy."
A retrospective review of consecutive patients who underwent attempted OTSC placement (either as primary or rescue therapy) for the indication of GI leak, fistula or perforation at 16 academic centers in the United States, The Netherlands, Germany, Italy, and Chile was conducted between May 2006 and November 2012. Patients were identified by using endoscopic databases at each institution. Anastomotic leak was defined as disruption at a surgical anastomosis resulting in a fluid collection with or without evidence of extravasation of contrast medium on radiologic evaluation. Fistula was defined as abnormal communication between two epithelialized surfaces. Perforation was defined as an unintentional, acute iatrogenic, full-thickness defect in the GI tract. The main outcome measurement was the long-term success of the procedure.
A total of 188 patients (108 fistulae, 48 perforations, 32 leaks) were included. Long-term success was
achieved in 60.2 percent of patients during a median follow-up of 146 days. The rate of successful closure of perforations (90 percent) and leaks (73.3 percent) was significantly higher than that of fistulae (42.9 percent). Long-term success was significantly higher when OTSCs were applied as primary therapy (primary 69.1 percent vs. rescue 46.9 percent). On multivariate analysis, patients who had OTSC placement for perforations and leaks had significantly higher long-term success compared with those who had fistulae.
In an accompanying editorial, Danny Cheriyan, MB, Bch, MRCPI and Robert Enns, MD, FRCP, Division of Gastroenterology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada, state "The future of the OTSC in mainstream endoscopy is promising. It is arguable that these clips should be available in every well-stocked unit, and because application and deployment are similar to those of a standard ligation bander, it would be appropriate for implementation into training and clinical practice in gastroenterology."
INFORMATION:
About the American Society for Gastrointestinal Endoscopy
Since its founding in 1941, the American Society for Gastrointestinal Endoscopy (ASGE) has been dedicated to advancing patient care and digestive health by promoting excellence and innovation in gastrointestinal endoscopy. ASGE, with more than 13,000 members worldwide, promotes the highest standards for endoscopic training and practice, fosters endoscopic research, recognizes distinguished contributions to endoscopy, and is the foremost resource for endoscopic education. Visit http://www.asge.org and http://www.screen4coloncancer.org for more information and to find a qualified doctor in your area.
About Endoscopy
Endoscopy is performed by specially-trained physicians called endoscopists using the most current technology to diagnose and treat diseases of the gastrointestinal tract. Using flexible, thin tubes called endoscopes, endoscopists are able to access the human digestive tract without incisions via natural orifices. Endoscopes are designed with high-intensity lighting and fitted with precision devices that allow viewing and treatment of the gastrointestinal system.
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