PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Risk stratification model may aid in lung cancer staging and treatment decisions

2014-11-05
(Press-News.org) DENVER – A risk stratification model based on lymph node characteristics confirms with a high level of confidence the true lack of lung cancer in lymph nodes adequately sampled with endobronchial ultrasound-guided transbronchial needle aspiration and classified as negative.

Lung cancer treatment and prognosis is critically dependent on accurate staging that takes into account the extent to which cancer has spread from the primary lung tumor to other locations. Examination of lymph nodes containing lung cancer cells that have spread can be done by surgical removal, historically the standard practice, or by using a less invasive more cost effective technique called endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The use of EBUS-TBNA is well established in several countries throughout the world and how to stage the patients based on a positive result is defined. Less clear is how to stage and treat patients with negative EBUS-TBNA results.

Researchers at the University Hospital of South Manchester, United Kingdom examined 329 lymph nodes that were classified as EBUS-TBNA negative from patients with pathologically diagnosed or, in a limited number of cases, clinically diagnosed lung cancer. One hundred ninety six of the lymph nodes were used to derive a model based on lymph node radiologic and ultrasound characteristics for high or low risk of actually being positive for lung cancer upon further evaluation. The model was then validated with the remaining 133 lymph nodes.

Results published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), show that lymph nodes categorized as low risk by the model had between a 98% and 99% chance of being truly negative based on the validation and derivation sets, respectively. Lymph nodes categorized in the model as high risk of being truly malignant was 65% in both the validation and derivation sets following a false negative EBUS-TBNA classification.

The authors acknowledge that "radiological staging will never replace pathological staging, but in cases of negative or inadequate EBUS-TBNA sampling our study demonstrates that the combination of radiologic and ultrasound data post-test can stratify patients into low and high risk for nodal malignancy". The authors are committed to further data collection and analysis of the model and conclude "this risk stratification model provides a mechanism for lung cancer multidisciplinary teams to discuss the risk of false negative EBUS-TBNA sampling, which may ultimately assist in the decision making process for either further staging procedures or direct progression to treatment".

INFORMATION:

First author Matthew Evison, lead author Philip A. J. Crosbie, and co-author Richard Booton are members of IASLC.

About the IASLC

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 4,000 lung cancer specialists in 80 countries. To learn more about IASLC please visit http://www.iaslc.org



ELSE PRESS RELEASES FROM THIS DATE:

Retinal-scan analysis can predict advance of macular degeneration, Stanford study finds

2014-11-05
Stanford University School of Medicine scientists have found a new way to forecast which patients with age-related macular degeneration are likely to suffer from the most debilitating form of the disease. The new method predicts, on a personalized basis, which patients' AMD would, if untreated, probably make them blind, and roughly when this would occur. Simply by crunching imaging data that is already commonly collected in eye doctors' offices, ophthalmologists could make smarter decisions about when to schedule an individual patient's next office visit in order to optimize ...

NASA's TRMM and GPM satellites analyze Hurricane Vance before landfall

NASAs TRMM and GPM satellites analyze Hurricane Vance before landfall
2014-11-05
Hurricane Vance was a hurricane on Nov. 4 when the Tropical Rainfall Measuring Mission or TRMM satellite and the Global Precipitation Measurement (GPM) mission satellite passed overhead and measured its rainfall from space. TRMM and GPM revealed areas of heavy rain within the storm before it weakened to a depression and made landfall on Nov. 5. The TRMM satellite flew over hurricane Vance on Nov. 4 at 0953 UTC (4:53 a.m. EST). Rainfall derived from TRMM's Microwave Imager (TMI) data collected were overlaid on a 1000 UTC (5 a.m. EST) image from NOAA's GOES-West satellite ...

NASA sees Typhoon Nuri pass Iwo To, Japan

NASA sees Typhoon Nuri pass Iwo To, Japan
2014-11-05
Typhoon Nuri continued moving in a northeasterly direction passing the island of Iwo To, Japan when NASA's Aqua satellite passed overhead. The Moderate Resolution Imaging Spectroradiometer or MODIS instrument that flies aboard NASA's Aqua satellite captured a visible picture of Typhoon Nuri on Nov. 5 at 4:10 UTC (11:10 p.m. EST, Nov. 4). At 1002 UTC (5:02 a.m. EST) a microwave image captured from NASA/JAXA's Tropical Rainfall Measuring Mission or TRMM satellite showed that the low-level center of circulation was beginning to weaken. The strongest thunderstorms had become ...

Interstitial lung disease is a significant risk factor for lung inflammation following stereotactic body radiation therapy for lung cancer

2014-11-05
DENVER – Pretreatment interstitial lung disease (ILD) is a significant risk factor for developing symptomatic and severe radiation pneumonitis in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT) alone. ILD is a group of diseases that cause scarring and stiffing of the tissue and space around the air sacs in the lungs, which results in diminished gas exchange. The incidence of ILD among lung cancer patients is higher than in the general population as tobacco smoking is a common risk factor for both. Some ...

Shape of things to come in platelet mimicry

Shape of things to come in platelet mimicry
2014-11-05
CLEVELAND—Artificial platelet mimics developed by a research team from Case Western Reserve University and University of California, Santa Barbara, are able to halt bleeding in mouse models 65 percent faster than nature can on its own. For the first time, the researchers have been able to integratively mimic the shape, size, flexibility and surface chemistry of real blood platelets on albumin-based particle platforms. The researchers believe these four design factors together are important in inducing clots to form faster selectively at vascular injury sites while ...

EARTH Magazine: Tiny ants are heroic weathering agents

2014-11-05
Alexandria, Va. — Earth's abundant silicate minerals are degraded over time by exposure to water, chemical dissolution, and physical and chemical weathering by tree roots and even insects such as ants and termites. Such weathering plays a significant role in decreasing carbon dioxide in the atmosphere, as carbon dioxide is consumed in chemical weathering reactions and the resultant carbonate becomes sequestered in the form of limestone and dolomite. To study the effects of weathering over time, researchers buried basalt sand at multiple test sites and dug up the ...

Can love make us mean?

Can love make us mean?
2014-11-05
BUFFALO, N.Y. – Empathy is among humanity's defining characteristics. Understanding another person's plight can inspire gentle emotions and encourage nurturing behaviors. Yet under certain circumstances, feelings of warmth, tenderness and sympathy can in fact predict aggressive behaviors, according to a recent study by two University at Buffalo researchers. But why? That an expression of kindness might be manifest as a punch in the nose can leave observers scratching their heads. The answer is that it's not about anger or feeling personally threatened, says ...

New e-Incubator enables real-time imaging of bioengineered tissues in controlled unit

New e-Incubator enables real-time imaging of bioengineered tissues in controlled unit
2014-11-05
"New Rochelle, NY, November 5, 2014—The e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under controlled conditions and to study their growth and development in real-time without risk of contamination or damage. Offering the potential to test engineered tissues before human transplantation, increase the success rate of implantation, and accelerate the translation of tissue engineering methods from the lab to the clinic, the novel e-incubator is described ...

IU researchers: Protein linked to aging identified as new target for controlling diabetes

IU researchers: Protein linked to aging identified as new target for controlling diabetes
2014-11-05
INDIANAPOLIS -- Indiana University School of Medicine researchers have identified a small protein with a big role in lowering plasma glucose and increasing insulin sensitivity. Their research appeared online today in Diabetes, the journal of the American Diabetes Association. The report indicates that Sestrin 3 plays a critical role in regulating molecular pathways that control the production of glucose and insulin sensitivity in the liver, making it a logical target for drug development for type 2 diabetes and metabolic syndrome, which can produce increased blood pressure, ...

How corals can actually benefit from climate change effects

How corals can actually benefit from climate change effects
2014-11-05
Researchers from Northeastern University's Marine Science Center and the University of North Carolina at Chapel Hill have found that moderate ocean acidification and warming can actually enhance the growth rate of one reef-​​building coral species. Only under extreme acidification and thermal conditions did calcification decline. Their work, which was published Wednesday in the journal Proceedings of the Royal Society B: Biological Sciences, is the first to show that some corals may benefit from moderate ocean acidification. Justin Ries, an associate professor ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Risk stratification model may aid in lung cancer staging and treatment decisions