PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Impact of post-treatment surveillance in head and neck squamous cell cancer

2015-05-07
(Press-News.org) Compliance with post-treatment surveillance, income level and the travel distance for follow-up care had effects on survival in patients with head and neck squamous cell cancer (HNSCC), according to a report published online by JAMA Otolaryngology-Head & Neck Surgery.

Post-treatment surveillance is a key component for patients with HNSCC, a cancer with a five-year survival rate of only slightly above 50 percent. The National Comprehensive Cancer Network guidelines recommend follow-up should consist of visits at least every one to three months during the first year after treatment, every two to four months in the second year, every four to six months in the third to fifth years, and then yearly after that. But the ability to complete post-treatment surveillance may be influenced by a number of factors, according to the study background.

Michael W. Deutschmann, M.D., F.R.C.S.C., of the University of Kansas Medical Center, Kansas City, and coauthors studied 332 patients who completed both treatment and follow-up at the facility. Patient and tumor characteristics, socioeconomic status and geographic data were collected to examine the effect of compliance with post-treatment surveillance on survival.

The 332 patients were followed for an average of 45 months. Of the patients, 246 (74 percent) presented with advanced disease and treatments included surgery and radiation, alone or combined, along with chemoradiation and surgery plus chemoradiation. Most patients (213 or 64 percent) did not develop a recurrence.

More than half of the patients (198) lived within 50 miles of the treatment center, while 22 (7 percent) lived more than 200 miles away. More than half of the patients (180) lived in middle census tract income levels and nearly half of the patients (49 percent) did not miss any appointments. However, 101 patients (30 percent) were considered noncompliant because they had missed three or more appointments during the surveillance period.

The authors found a relationship between compliance and tobacco cessation, as well as the distance a patient lived from the treatment center. Patients who quit smoking, lived in high-income census tracts and lived closer to the medical center were more likely than expected to have kept all of their appointments.

"Patients who were compliant with their PTS [post-treatment surveillance] were significantly more likely to quit tobacco products, and those who quit had improved survival," the study concludes.

INFORMATION:

(JAMA Otolaryngol Head Neck Surg. Published online May 7, 2015. doi:10.1001/.jamaoto.2015.0643. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Media Advisory: To contact corresponding author Michael W. Deutschmann, M.D., F.R.C.S.C., call Natalie Lutz at 913-588-2598 or email nlutz3@kumc.edu.

To place an electronic embedded link to this study in your story Links will be live at the embargo time: http://archotol.jamanetwork.com/article.aspx?doi=10.1001/jamaoto.2015.0643



ELSE PRESS RELEASES FROM THIS DATE:

Statins associated with longer prostate cancer time to progression during ADT

2015-05-07
The use of cholesterol-lowering statins when men initiated androgen deprivation therapy for prostate cancer was associated with longer time to progression of the disease, according to an article published online by JAMA Oncology. The gene SLCO2B1 acts as a transporter that enables a variety of drugs and hormones to enter cells. For example, dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and uses SLCO2B1 to get into cells. Similarly, statins use SLCO2B1 to enter cells as well. Previous research has suggested an association between statin use and ...

Evidence of efficacy of gene therapy in rodents affected by a rare genetic liver disease, Crigler-Na

2015-05-07
Crigler-Najjar syndrome is a rare autosomal recessive disorder caused by mutations in the UGT1A1 gene, which result in the toxic accumulation of bilirubin, a substance made by the liver in the body. Indeed, when the UDP-glucuronosyltransferase 1 isotype A1 (UGT1A1), the enzyme responsible for removing bilirubin, doesn't work, the substance accumulates, causing a severe and chronic jaundice, and becoming toxic for the brain and leading to lethality. Gene therapy has allowed the restoration of an equivalent level of bilirubin to those found in healthy animals Federico ...

IRF5, a new player in the occurrence of obesity complications

2015-05-07
This news release is available in French. Metabolic complications of obesity and overweight, such as type 2 diabetes, are an important challenge to public health. Teams led by Nicolas Venteclef, Inserm Research Fellow (Cordeliers Research Centre, Inserm/Pierre and Marie Curie University Joint Research Unit 1138, Paris, France) and Irina Udalova (Kennedy Institute of Rheumatology, University of Oxford, UK) in collaboration with several teams, have succeeded in elucidating part of the mechanisms involved in the development of these metabolic complications associated with ...

Role of obesity and depression in excessive daytime sleepiness

2015-05-07
Obesity and depression -- not only lack of sleep -- are underlying causes for regular drowsiness, according to Penn State College of Medicine researchers. They say these findings could lead to more personalized sleep medicine for those with excessive daytime sleepiness (EDS). As much as 30 percent of the general population experiences EDS -- daytime drowsiness or sleepiness occurring throughout the day that can include irresistible sleep attacks. Feeling overly tired during the day can reduce job productivity and increase errors and absenteeism and may lead to more serious ...

Nuclear medicine scan could identify who might benefit from aromatase inhibitor treatment

2015-05-07
A new, noninvasive nuclear medicine test can be used to determine whether aromatase inhibitor treatment will be effective for specific cancer patients, according to a recent study reported in The Journal of Nuclear Medicine. The research shows that a PET scan with the ligand C-11-vorozole reliably detects aromatase in all body organs - demonstrating the value of its future use to pre-determine the effectiveness of the treatment for breast, ovarian, endometrial and lung cancer patients, potentially reducing unnecessary treatment costs and adverse effects. Aromatase inhibitors ...

New care approach to colorectal operations speeds patients' recovery times

2015-05-07
CHICAGO (May 7, 2015): Patients undergoing colorectal operations who participated in an enhanced recovery program left the hospital sooner and had significantly lower hospital costs than patients who had the traditional approach to their care, according to a new study, which also found further postoperative improvements after adding an infection prevention protocol. The study is published online as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication later this year. "Enhanced recovery after surgery" is a multicomponent ...

Brandeis researchers identify potential cause of schizophrenic symptoms

2015-05-07
Schizophrenia affects millions of people worldwide but the cause of its wide-ranging symptoms remains largely unknown. At Brandeis University, researchers believe they have discovered an abnormality in the schizophrenic brain that could be responsible for many of the disease's symptoms and could provide a drug target for therapeutic treatments. Led by John Lisman, the Zalman Abraham Kekst Chair in Neuroscience and professor of biology, the research team published their findings in a recent issue of the Journal of Biological Psychiatry. The paper was co-authored by ...

Potential for a more personalized approach to womb cancer

2015-05-07
Traditionally, patients with endometrial cancer -- cancer of the womb lining -- have their disease risk classified using a combination of clinical and tissue characteristics, including their age and the growth and invasion of their tumour. Around 15-20% of patients have high-risk disease, but it is unclear what the best treatment approach is for these patients. Now Manchester researchers have investigated genetic alterations in high-risk endometrial cancer, to see if they could be used to create tumour subtypes. Professor Richard Edmondson, Professor of Gynaecological ...

Journal Maturitas position statement: Non-hormonal management of menopausal vasomotor symptoms

2015-05-07
Amsterdam, May 7, 2015 -- Elsevier journal Maturitas today announced the publication of a position statement by the European Menopause and Andropause Society (EMAS) covering non-hormonal management of menopausal vasomotor symptoms. Hot flashes are a common menopausal symptom. They tend to intensify during the perimenopause and usually subside within 5 years after the final menstrual period. However in some women frequent hot flashes are a long term problem and may last for more than 7 years. While estrogen-based menopausal hormone therapy is the most effective treatment ...

Antioxidant effects of coffee by-products 500 times greater than vitamin C

Antioxidant effects of coffee by-products 500 times greater than vitamin C
2015-05-07
It has traditionally been assumed that these by-products - coffee grounds and coffee silverskin, have few practical uses and applications. Spent coffee grounds are sometimes employed as homemade skin exfoliants or as abrasive cleaning products. They are also known to make great composting agents for fertilizing certain plants. But apart from these limited applications, coffee by-products are by and large deemed to be virtually useless. As such, practically all of this highly contaminating 'coffee waste' ends up in landfills across the globe and has a considerable knock-on ...

LAST 30 PRESS RELEASES:

NTIDE: Disability employment holds steady after data hiatus

Social lives of viruses affect antiviral resistance

Dose of psilocybin, dash of rabies point to treatment for depression

Helping health care providers navigate social, political, and legal barriers to patient care

Barrow Neurological Institute, University of Calgary study urges “major change” to migraine treatment in Emergency Departments

Using smartphones to improve disaster search and rescue

Robust new photocatalyst paves the way for cleaner hydrogen peroxide production and greener chemical manufacturing

Ultrafast material captures toxic PFAS at record speed and capacity

Plant phenolic acids supercharge old antibiotics against multidrug resistant E. coli

UNC-Chapel Hill study shows AI can dramatically speed up digitizing natural history collections

OYE Therapeutics closes $5M convertible note round, advancing toward clinical development

Membrane ‘neighborhood’ helps transporter protein regulate cell signaling

Naval aviator turned NPS doctoral student earns national recognition for applied quantum research

Astronomers watch stars explode in real time through new images

Carbon-negative building material developed at Worcester Polytechnic Institute published in matter

Free radicals caught in the act with slow spectroscopy

New research highlights Syntax Bio’s platform for simple yet powerful programming of human stem cells

Researchers from the HSE University investigated reading in adolescents

Penn Nursing study: Virtual nursing programs in hospitals fall short of expectations

Although public overwhelmingly supports hepatitis B vaccine for a newborn, partisan differences exist

DFW backs UTA research to bolster flood resilience

AI brain scan model identifies stroke, brain tumors and aneurysms – helping radiologists triage and speed up diagnoses

U.S. News & World Report gives Hebrew Rehabilitation Center highest rating

Optica and DPG name Antoine Browaeys 2026 Herbert Walther Award recipient

The presence of a gun in the home increases the risk of suicide by three to five times

PFAS exposure and endocrine disruption among women

Vaccines and the 2024 US presidential election

New approach narrows uncertainty in future warming and remaining carbon budget for 2 °C

When pregnancy emergencies collide with state abortion bans

American College of Cardiology supports front of package nutrition labeling

[Press-News.org] Impact of post-treatment surveillance in head and neck squamous cell cancer