(Press-News.org) In an analysis of the findings of nearly 80 randomized trials that included about 6,500 participants, there was moderate-quality evidence to support the use of cannabinoids (chemical compounds that are the active principles in cannabis or marijuana) for the treatment of chronic pain and lower-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, sleep disorders, and Tourette syndrome, according to a study in the June 23/30 issue of JAMA.
Medical cannabis refers to the use of cannabis or cannabinoids as medical therapy to treat disease or alleviate symptoms. In the United States, 23 states and Washington, D.C., have introduced laws to permit the medical use of cannabis; many other countries have similar laws. Despite the wide us of cannabis and cannabinoid drugs for medical purposes, their efficacy for specific indications is not clear, according to background information in the article.
Penny F. Whiting, Ph.D., of the University of Bristol, Bristol, United Kingdom, and colleagues evaluated the evidence for the benefits and adverse events (AEs) of medical cannabinoids by searching various databases for randomized clinical trials of cannabinoids for a variety of indications. The researchers identified 79 trials (6,462 participants) that met criteria for inclusion in the review and meta-analysis.
The researchers found that most studies suggested that cannabinoids were associated with improvements in symptoms, but these associations did not reach statistical significance in all studies. There was moderate-quality evidence to suggest that cannabinoids may be beneficial for the treatment of chronic neuropathic or cancer pain and spasticity due to multiple sclerosis (sustained muscle contractions or sudden involuntary movements). There was low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV, sleep disorders, and Tourette syndrome; and very low-quality evidence for an improvement in anxiety. There was low-quality evidence for no effect on psychosis and very low-level evidence for no effect on depression.
There was an increased risk of short-term AEs with cannabinoids, including serious AEs. Common AEs included dizziness, dry mouth, nausea, fatigue, somnolence, euphoria, vomiting, disorientation, drowsiness, confusion, loss of balance, and hallucination. There was no clear evidence for a difference in association (either beneficial or harmful) based on type of cannabinoids or mode of administration. Only 2 studies evaluated cannabis. There was no evidence that the effects of cannabis differed from other cannabinoids.
"Further large, robust, randomized clinical trials are needed to confirm the effects of cannabinoids, particularly on weight gain in patients with HIV/AIDS, depression, sleep disorders, anxiety disorders, psychosis, glaucoma, and Tourette syndrome are required. Further studies evaluating cannabis itself are also required because there is very little evidence on the effects and AEs of cannabis," the authors write.
(doi:10.1001/jama.2015.6358; Available pre-embargo to the media at http://media.jamanetwork.com)
Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Editorial: Medical Marijuana
"If the states' initiative to legalize medical marijuana is merely a veiled step toward allowing access to recreational marijuana, then the medical community should be left out of the process, and instead marijuana should be decriminalized," write Deepak Cyril D'Souza, M.B.B.S., M.D., and Mohini Ranganathan, M.D., of the Yale University School of Medicine, New Haven, Conn., in an accompanying editorial.
"Conversely, if the goal is to make marijuana available for medical purposes, then it is unclear why the approval process should be different from that used for other medications. Evidence justifying marijuana use for various medical conditions will require the conduct of adequately powered, double-blind, randomized, placebo/active controlled clinical trials to test its short- and long-term efficacy and safety. The federal government and states should support medical marijuana research. Since medical marijuana is not a life-saving intervention, it may be prudent to wait before widely adopting its use until high-quality evidence is available to guide the development of a rational approval process."
(doi:10.1001/jama.2015.6407; Available pre-embargo to the media at http://media.jamanetwork.com)
Editor's Note: Please see the article for additional information, including financial disclosures, funding and support, etc.
INFORMATION:
An analysis of edible medical marijuana products from 3 major metropolitan areas found that many had lower amounts of key substances than labeled, which may not produce the desired medical benefit, while others contained significantly more of a certain substance than labeled, placing patients at risk of experiencing adverse effects, according to a study in the June 23/30 issue of JAMA.
As the use of cannabis (marijuana) for medical purposes has expanded, a variety of edible products for oral consumption has been developed. An estimated 16 percent to 26 percent of patients ...
In a proof-of-concept study, a team led by a Johns Hopkins researcher reports that the vast majority of edible cannabis products sold in a small sample of medical marijuana dispensaries carried labels that overstated or understated the amount of delta-9-tetrahydrocannabinol (THC).
Though the scope of the study was small, the researchers say, the results of the study suggest some medical cannabis patients could be unintentionally overdosing or are being cheated by mislabeled products.
"If this study is representative of the medical cannabis market, we may have hundreds ...
BOSTON, June 23 -- In a Viewpoint published today in the Journal of the Medical Association (JAMA), researchers from the Friedman School of Nutrition Science and Policy at Tufts University and Boston Children's Hospital call on the federal government to drop restrictions on total fat consumption in the forthcoming 2015 Dietary Guidelines for Americans.
Co-authors Dariush Mozaffarian, M.D., Dr.P.H., dean of the Friedman School, and David Ludwig, M.D., Ph.D., director of the New Balance Foundation Obesity Prevention Center at Boston Children's Hospital, highlight a key, ...
ANN ARBOR--A months-long literature search that involved tracking down century-old scientific papers and translating others from Czech and French helped University of Michigan ecologist Meghan Duffy answer a question she'd wondered about for years.
The early studies helped Duffy determine that the microscopic aquatic parasite she first observed as a graduate student, and which her research team had recently collected in more than a dozen southeast Michigan lakes, is the same fungus-like organism that a French biologist first described in 1903.
"The longer historical ...
U.S. consumers are often urged to "buy American," and some special interest groups even claim that buying foreign products is inappropriate, or even immoral. But when it comes to buying domestic products, positive feelings for one's own country may play a more important role than negative feelings toward another, according to a new study in the Journal of International Marketing.
"National identity--feeling proud to be, say, an American--and believing that Americans should not buy foreign products influence attitudes toward domestic products, but the impact of national ...
More than four out of five counselors who treat patients for substance abuse have experienced some form of patient-initiated workplace violence according to the first national study to examine the issue, led by Georgia State University Professor Brian E. Bride.
The study, forthcoming in the Journal of Substance Abuse Treatment, is the first to measure the extent of workplace violence in substance abuse treatment centers across the United States. Bride and his co-authors analyzed a large, national sample of Substance Use Disorder counselors from the National Institutes ...
Everyone in China knows global automobile brands such as Ford and Chevrolet. But do those brands really sell better than local ones such as Senova or Eado? The answer is yes, and the reason lies in a complicated mix of brand recognition and local culture, according to a new study in the Journal of International Marketing.
"In countries such as China with strong class divisions, internationally recognized brands can be a way of conveying wealth, prestige, and status," write authors M. Berk Talay (University of Massachusetts), Janell D. Townsend (Oakland University), and ...
ANN ARBOR--A University of Michigan researcher and his colleagues are forecasting a slightly below-average but still significant "dead zone" this summer in the Chesapeake Bay, the nation's largest estuary.
The 2015 Chesapeake Bay forecast calls for an oxygen-depleted, or hypoxic, region of 1.37 cubic miles, about 10 percent below the long-term average. The forecast was released today by the National Oceanic and Atmospheric Administration, which sponsors the work.
Farmland runoff containing fertilizers and livestock waste is the main source of the nitrogen and phosphorus ...
CAMDEN, N.J. -- How do we remember colors? What makes green... green?
As Sarah Allred explains, while color perception universally involves the practice of categorizing colors according to basic labels, the influence of categorization on color memory remains largely unknown and understudied.
'So that leaves a lot of questions unanswered,' says Allred, an assistant professor of psychology at Rutgers University-Camden. ''Do we remember colors just as we saw them?', 'Does time affect how we remember colors?', 'Are some colors easier to remember than others?''
Thanks ...
Just because more men pursue careers in science and engineering does not mean they are actually better at math than women are. The difference is that men think they are much better at math than they really are. Women, on the other hand, tend to accurately estimate their arithmetic prowess, says Shane Bench of Washington State University in the U.S., leader of a study in Springer's journal Sex Roles.
There is a sizeable gap between the number of men and women who choose to study and follow careers in the so-called STEM fields of science, technology, engineering and mathematics ...
