Assessment of duplicate evidence in systematic reviews of imaging findings of children with COVID-19

(New York, NY - January 6, 2021) - Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing. The study advances our understanding of the mechanisms of AD and could pave the way for developing novel, personalized therapeutics. The work was funded by the National Institute on Aging, part of the National Institutes of Health (NIH), and published in Science Advances on January 6, 2021. RNA is a genetic molecule similar to DNA that encodes the instructions for making proteins. RNA sequencing is a technology that reveals the presence and quantity of RNA in a biological sample such as a brain slice. Alzheimer's ...

Sex chromosomes are presumed to originate from a pair of identical ancestral chromosomes by acquiring a male- or a female-determining gene on one chromosome. To prevent the sex-determining gene from appearing in the opposite sex, recombination is suppressed on sex chromosomes. This leads to the degeneration of Y chromosome (or the W chromosome in case of birds) and the morphological difference of sex chromosomes between sexes. For example, the human Y chromosome bears only less than 50 genes, while the human X chromosome still maintains over 1500 genes from the autosomal ancestor. This process occurred independently in birds, in ...

Femtosecond hard X-ray pulses are an important tool for unraveling structure changes of condensed matter on atomic length and time scales. A novel laser-driven X-ray source provides femtosecond copper Kα pulses at a 1 kHz repetition rate with an unprecedented flux of some 10^12 X-ray photons per second. Elementary processes in physics, chemistry, and biology are connected with changes of the atomic or molecular structure on a femtosecond time scale (1 femtosecond (fs) = 10^-15 seconds). Ultrafast X-ray methods hold strong potential for following structure changes in space and time and generate 'movies' of the motions of electrons, atoms and molecules. This perspective has ...

The Covid-19 pandemic is impacting people's mental health. But what helps and hinders people in getting through a lockdown? A new study led by researchers at the University of Basel addressed this question using data from 78 countries across the world. The results hint at the pivots and hinges on which the individual's psyche rests in the pandemic. At the outset of the Covid-19 pandemic, little was known about the impact of population-wide governmental lockdowns. What was known was taken from restricted quarantines of small groups of people. "On the one hand, such drastic changes to daily routines can be detrimental to mental health," explains Professor ...

People view the wolf as either a threatening predator or a sign of a healthy natural habitat. Many proponents of nature and animal conservation welcome the spread of wolf populations in Germany. By contrast, farmers who graze herds directly impacted by the wolves' return are more critical. The team of Nicolas Schoof, Prof. Dr. Albert Reif of the Chair of Site Classification and Vegetation Science at the University of Freiburg, and Prof. Dr. Eckhard Jedicke of the Competence Center Cultural Landscape and the Department of Landscape Planning and Nature Conservation of Hochschule Geisenheim University has assessed the existing legal situation. On the basis of a range of environmental data they have determined the conflicts and drawn up possible solutions. In an article in ...

Northeastern Asia has a complex history of migrations and plague outbursts. That is the essence of an international archaeogenetic study published in Science Advances and lead from the Department of Archaeology and Classical Studies at Stockholm University. Genomic data from archaeological remains from 40 individuals excavated in northeastern Asia were explored in the study. "It is striking that we find everything here, continuity as well as recurrent migrations and also disease-related bacteria", says Anders Götherström, professor at the Center for Palaeogenetics at Stockholm University and one of the Principal investigators of the study. The ...

Sleep is ubiquitous in animals and humans and vital for healthy functioning. Thus, sleep after training improves performance on various tasks in comparison to equal periods of active wakefulness. However, it has been unclear so far whether this is due to an active refinement of neural connections or merely due to the absence of novel input during sleep. Now researchers at the Medical Center - University of Freiburg have succeeded in showing that sleep is more than rest for improving performance. The findings, which were published in the journal SLEEP on January 6, 2021, provide important information for planning periods of intensive ...

January 7, 2021 (BRAMPTON - HAMILTON) -- When dealing with a life-limiting illness, palliative care can improve the quality of life for patients and families. However, for many people, the fear of "end of life" care prevents them from exploring it. A recent study from William Osler Health System (Osler) and McMaster University examined awareness of palliative care in the South Asian community and found that culture plays a critical role in the perception of palliative care. This perception, in turn, affects whether or not patients will be open to receiving it. Funded by a McMaster University, Department ...

TORONTO, January 7, 2021- What feels like up may actually be some other direction depending on how our brains process our orientation, according to psychology researchers at York University's Faculty of Health. In a new study published in PLoS One, researchers at York University's Centre for Vision Research found that an individual's interpretation of the direction of gravity can be altered by how their brain responds to visual information. Laurence Harris, a professor in the Department of Psychology in the Faculty of Health and Meaghan McManus, a graduate student in his lab, found, using virtual reality, that people differ ...

DALLAS - Jan. 7, 2020 - A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer's disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. Researchers have long known that sticky plaques of a protein known as amyloid beta are a hallmark of Alzheimer's and are toxic to brain cells. As early as the mid-1990s, other proteins were discovered in these plaques as well. One of these, a protein known as transthyretin (TTR), ...