(Press-News.org) Oncotarget recently published "Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study" which reported that to investigate neuroendocrine carcinoma of the uterine cervix cases for MRI features and staging, as well as pathological correlations and survival.
In 50 patients who underwent a radical hysterectomy and lymphadenectomy without neoadjuvant chemotherapy, intrapelvic T staging by MRI overall accuracy was 88.0% with reference to pathology staging, while patient-based sensitivity, specificity, and accuracy for metastatic pelvic lymph node detection was 38.5%, 100%, and 83.3%, respectively.
Three-year progression-free and overall survival rates for FIGO I, II, III, and IV were 64.3% and 80.9%, 50% and 64.3%, 0% and 0%, and 0% and 0%, respectively.
Sixty-two patients with histologically surgery-proven uterine cervical NEC were enrolled.
The Oncotarget author's findings show that MRI is reliable for T staging of cervical NEC.
"The Oncotarget author's findings show that MRI is reliable for T staging of cervical NEC"
Dr. Kazuhiro Kitajima from The Department of Radiology at The Hyogo College of Medicine said, "Neuroendocrine carcinomas (NECs) of the female genital tract are aggressive uncommon tumors that usually involve the uterine cervix and ovaries, though are very rarely seen in the endometrium."
According to the World Health Organization classification, neuroendocrine tumors in the uterine cervix are categorized into 4 categories; typical carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma.
Cervical NEC has a higher frequency of lymphovascular invasion, lymphatic and distal metastasis, and recurrence as compared to other subtypes of uterine cervical malignancies, e. g., squamous cell carcinoma and adenocarcinoma.
However, findings obtained in smear and cervical biopsy analyses are insensitive and inconclusive for diagnosis of cervical NEC in some patients, due to limited sample size or tumor heterogeneity.
To the best of these researcher's knowledge, 2 different reports have been presented that include discussion of MRI characteristics of uterine cervical SCNEC, with a small number of patients in each, while no known reports discussing MRI findings of cervical LCNEC are available.
The aim of this study was to identify the distinct features and staging accuracy of uterine cervical NEC, including SCNEC and LCNEC, using MRI, as well as pathological correlations.
The Kitajima Research Team concluded in their Oncotarget Research Paper that NEC of the uterine cervix is rare and affected patients have a poor prognosis, especially advanced stage cases.
A definitive diagnosis based on preoperative MRI results seems to be difficult. Nevertheless, the present as well as other previous findings indicate that a homogeneous lesion texture with an obvious restricted diffusion throughout the tumor are suggestive of uterine cervical NEC.
Furthermore, they found pelvic MRI to provide reliable imaging findings for T staging in these patients.
Sign up for free Altmetric alerts about this article
DOI - https://doi.org/10.18632/oncotarget.27613
Full text - https://www.oncotarget.com/article/27613/text/
Correspondence to - Kazuhiro Kitajima - ka-kitajima@hyo-med.ac.jp
Keywords -
cervical cancer,
neuroendocrine carcinoma,
small cell carcinoma,
large cell carcinoma,
MRI
About Oncotarget
Oncotarget is a biweekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.
To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:
SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls
Oncotarget recently published "Simvastatin is a potential candidate drug in ovarian clear cell carcinomas" which reported that based on previous studies, the authors assessed the anti-proliferative effect of simvastatin, a Rho GTPase interfering drug, in three OCCC cell lines: JHOC-5, OVMANA and TOV-21G, and one high-grade serous ovarian cancer cell line, Caov3. The authors used the Rho GTPase interfering drug CID-1067700 as a control.
All OCCC cell lines were more sensitive to single-agent simvastatin than the HGSOC cells, while all cell lines were less sensitive to CID-1067700 than to simvastatin.
Most treatments inhibited migration, ...
COLUMBUS, Ohio - A new deep-learning model that can predict how human genes and medicines will interact has identified at least 10 compounds that may hold promise as treatments for COVID-19.
All but two of the drugs are still considered investigational and are being tested for effectiveness against hepatitis C, fungal disease, cancer and heart disease. The list also includes the approved drugs cyclosporine, an immunosuppressant that prevents transplant organ rejection, and anidulafungin, an antifungal agent.
The discovery was made by computer scientists, meaning much more work needs to be done before any of these medications would be confirmed as safe and effective treatments ...
Michelle O'Malley(link is external) has long been inspired by gut microbes. Since she began studying the herbivore digestive tract, the UC Santa Barbara chemical engineering professor has guided several students to their doctoral degrees, won early and mid-career awards (including a recognition from President Obama), attained tenure and advanced to the position of full professor. She even had three children along the way. A constant through it all: goat poop.
"This has been the longest single effort in my lab," said O'Malley, who with her research team way back in 2015 first embarked on an ambitious project to characterize gut microbes in large herbivores. The purpose? To understand how these animals manage, via their microbiomes, ...
Over the past century, a wide variety of models have emerged to explain the complex behaviours which unfold within atomic nuclei at low energies. However, these theories bring up deep philosophical questions regarding their scientific value. Indeed, traditional epistemological tools have been rather elaborated to account for a unified and stabilised theory rather than to apprehend a plurality of models. Ideally, a theory is meant to be reductionist, unifying and fundamentalist. In view of the intrinsic limited precision of their prediction and of the difficulty in assessing a priori their range of applicability, as well as of their specific and disconnected character, traditional ...
RESEARCH TRIANGLE PARK, N.C. -- Army-funded researchers discovered how to make materials capable of self-propulsion, allowing materials to move without motors or hands.
Researchers at the University of Massachusetts Amherst discovered how to make materials that snap and reset themselves, only relying upon energy flow from their environment. This research, published in Nature Materials and funded by the U.S. Army, could enable future military robots to move from their own energy.
"This work is part of a larger multi-disciplinary effort that seeks to understand biological and engineered impulsive systems that will lay the foundations for scalable methods for generating forces for mechanical action and energy storing structures and materials," said Dr. Ralph ...
WASHINGTON -- In a new study, investigators report an optimized approach to using laser-induced breakdown spectroscopy (LIBS) for analyzing hydrogen isotopes. Their new findings could enable improved rapid identification and measurement of hydrogen and other light isotopes that are important in nuclear reactor materials and other applications.
LIBS is promising for measuring hydrogen isotopes because it requires no sample preparation and data can be rapidly acquired with a relatively simple experimental setup. However, quantifying the concentration of hydrogen ...
Oncotarget published "The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling" which reported that the authors have previously shown that a flaxseed-supplemented diet decreases both the incidence and severity of ovarian cancer in laying hens, also induces CYP1A1 expression in liver.
Recently, they have shown that as a biologically derived active component of flax diet, 2MeOE2 induces apoptosis in ovarian cancer cells which is partially dependent on p38 MAPK.
The objective of this Oncotarget study was to elucidate the molecular mechanism of actions of 2MeOE2, a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors.
The objective of this ...
Each year, billions of tons of goods are transported globally using cargo containers. Currently, there are concerns that this immense volume of traffic could be exploited to transport illicit nuclear materials, with little chance of detection. One promising approach to combating this issue is to measure how goods interact with charged particles named muons - which form naturally as cosmic rays interact with Earth's atmosphere. Studies worldwide have now explored how this technique, named 'muon tomography,' can be achieved through a variety of detection technologies and reconstruction algorithms. In this article of EPJ Plus, a team headed by Francesco Riggi at the University of Catania, Italy, build on these results to develop a full-scale muon tomograph ...
As the numbers of those infected with COVID-19 has continued to climb, the desperate need for a vaccine was apparent. Even now with the invention and administration of several COVID-19 vaccinations, the question remains: How effective are these vaccines? HMNTL students Congnyu Che, Weijing Wang, and Nantao Li, also members of the ECE Nanosensors Group, along with Postdoctoral Researcher Bin Zhao and Professor Brian Cunningham have recently been published in Talanta journal for the development of a cost efficient COVID-19 antibody test.
"Compared with other detection methods, our method is a simple, 15-minute sample-to-answer test," says Zhao, a postdoctoral research associate and IGB Fellow. "It costs less ...
People who are unable to make their rent or mortgage payments sleep less than than their peers who don't have such problems, and those who are forced to move because of financial problems sleep even less, according to a new RAND Corporation study.
The study, which followed 1,046 people receiving welfare in California over several years, is the first to analyze the relationship between housing insecurity and sleep outcomes after controlling for sleep duration and sleep quality measured prior to experiences with housing insecurity.
The study found that people who were unable to make a rent or mortgage payment slept on average 22 fewer minutes a night than their peers who were able to make their rent or mortgage payments.
People who were ...
