Automated imaging detects and tracks brain protein involved in Alzheimer's disease

Nearly 11 percent of people admitted to an intensive care unit in Sweden between 2010 and 2018 received opioid prescriptions on a regular basis for at least six months and up to two years after discharge. That is according to a study by researchers at Karolinska Institutet published in Critical Care Medicine. The findings suggest some may become chronic opioid users despite a lack of evidence of the drugs' long-term effectiveness and risks linked to increased mortality. "We know that the sharp rise in opioid prescriptions in the U.S. has contributed to a deadly opioid crisis there," says first author Erik von Oelreich, PhD student in the Department of Physiology and ...

A decision-support tool that could be accessed via mobile devices may help clinicians in lower-resource settings avoid unnecessary antibiotic prescriptions for children with diarrhoea, a study published today in eLife shows. The preliminary findings suggest that incorporating real-time environmental, epidemiologic, and clinical data into an easy-to-access, electronic tool could help clinicians appropriately treat children with diarrhoea even when testing is not available. This could help avoid the overuse of antibiotics, which contributes to the emergence of drug-resistant bacteria. "Diarrhoea is a common condition among children ...

FRANKFURT. Chronic liver disease and even cirrhosis can go unnoticed for a long time because many patients have no symptoms: the liver suffers silently. When the body is no longer able to compensate for the liver's declining performance, the condition deteriorates dramatically in a very short time: tissue fluid collects in the abdomen (ascites), internal bleeding occurs in the oesophagus and elsewhere, and the brain is at risk of being poisoned by metabolic products. This acute decompensation of liver cirrhosis can develop into acute-on-chronic liver failure with inflammatory reactions throughout the body and failure of several organs. In the PREDICT study, led ...

BLOOMINGTON, Ind. - In Lily Tomlin's classic SNL comedy sketch, her telephone operator "Ernestine" famously delivers the punchline, "We don't care. We don't have to. We're the Phone Company." But new research finds that satisfied customers mean increased profits even for public utilities that don't face competition. Little is known about effect of customer satisfaction at utilities. As a result, utility managers are often unsure how much to invest in customer service - if anything at all. The issue also is of interest to regulators responsible for protecting consumers. The study, in ...

CORVALLIS, Ore. - One of birdwatching's most commonly held and colorfully named beliefs, the Patagonia Picnic Table Effect, is more a fun myth than a true phenomenon, Oregon State University research suggests. Owing its moniker to an Arizona rest area, the Patagonia Picnic Table Effect, often shortened to PPTE, has for decades been cited as a key driver of behavior, and rare-species-finding success, among participants in the multibillion-dollar recreational birding business - an industry that has gotten even stronger during a pandemic that's shut down so many other activities. But a study led by an OSU College of Science ...

Scientists and engineers at the University of Sydney and Microsoft Corporation have opened the next chapter in quantum technology with the invention of a single chip that can generate control signals for thousands of qubits, the building blocks of quantum computers. "To realise the potential of quantum computing, machines will need to operate thousands if not millions of qubits," said Professor David Reilly, a designer of the chip who holds a joint position with Microsoft and the University of Sydney. "The world's biggest quantum computers currently operate with just 50 or so qubits," he said. "This small scale is partly because of limits to the physical architecture that control the qubits." "Our ...

New research from the Okinawa Institute of Science and Technology Graduate University (OIST) has found a surprising randomness for how fluids choose their path around obstacles that depends on their spacing. This has important implications for a range of scenarios - from oil recovery and groundwater remediation, to understanding the movement of fluids through biological systems. The research was published in Physical Review Letters. Scientists from OIST's Micro/Bio/Nanofluidics Unit created a tiny set up comprised of two microscopic cylinders, each around the width of a human hair, placed side-by-side in a channel. This created a choice of three possible paths for a fluid to take past the pair of obstacles. A viscoelastic fluid, which is like that ...

OAK BROOK, Ill. - A technique that delivers high-intensity focused ultrasound to targeted tissue under MRI guidance effectively treats intermediate-risk prostate cancer with minimal side effects, according to a study published in Radiology. Prostate cancer is the most common cancer among men, aside from non-melanoma skin cancers. Common treatments to the entire gland, such as surgery and radiation therapy, are effective in eliminating the cancer, but they often leave patients with incontinence and sexual dysfunction. A class of treatments called focal therapy offers an alternative for some men with intermediate-risk disease that is still confined to the prostate. In focal therapy, the cancer is ablated, or destroyed, by either ...

By late summer 2020, the resurgence of COVID-19 in the United States was largely driven by adults between the ages of 20 and 49, a new study finds. The results indicate that in locations where novel highly transmissible SARS-CoV-2 lineages have not yet established, additional interventions among adults of these ages could bring resurgent COVID-19 epidemics under control and avert deaths. Following initial declines in the number of reported SARS-CoV-2 infections and deaths - a result largely attributed to non-pharmaceutical interventions - a resurgence in transmission of COVID-19 occurred in the United States and Europe beginning in August 2020. Understanding the age demographics that drove this is crucial. For example, between August ...

Laser particles are micrometre and nanometre lasers in the form of particles dispersible in aqueous solution, which have attracted considerable interest in the life sciences as a promising new optical probe. Laser particles emit highly bright light with extremely narrow spectral bandwidth. By transferring laser particles into live cells as shown in Figure 1, individual cells in a heterogeneous population can be tracked using each intracellular particle's specific spectral fingerprint as an optically readable barcode. However, laser particles emit directional light (Figure 2) and freely tumble inside living cells, their orientation varying randomly over time. Therefore optical readout of these labels results ...