A new effect of red ginseng: suppression of lung cancer metastasis
Development of KIST-maximized ginsenoside (KMxG) using a microwave processing method for ginseng that increase the trace amounts of Rk1 and Rg5. Ginsenosides Rk1 and Rg5 effectively inhibit the metastasis of lung cancer
2021-03-03
(Press-News.org) Red ginseng, which has long been used as an ingredient in traditional Korean medicine, has recently drawn increased attention as a functional material for its health-promoting effects. The composition and activities of red ginseng vary depending on the processing method, and this has become an active area of research. Recently, a research team in Korea has entered the spotlight as they discovered that red ginseng has inhibitory effects against lung cancer metastasis.
The Korea Institute of Science and Technology (KIST) reported that a joint study conducted by Dr. Jungyeob Ham from the Natural Product Research Center at the KIST Gangneung Institute of Natural Products and Dr. Hyeonseok Ko of Seoul Asan Medical Center revealed that two components of red ginseng, Rk1 and Rg5, can significantly suppress lung cancer metastasis.
Dr. Ham of KIST developed a new microwave processing method for red ginseng that is based on the same principle as a microwave oven, which when compared to existing processing methods, such as repetitive steaming and drying, increases the concentration of the three main active components, Rg3, Rk1, and Rg5, more than 20 times. The research team previously demonstrated that red ginseng produced by this microwave processing method, which they have called KMxG, is effective against prostate, cervical, and skin cancers, and has protective effects against by drug-induced kidney damage. This technology was transferred to Ponin Bio Co., Ltd. in 2020 for a technology fee of KRW 800 million and is currently being developed for commercialization.
Unlike normal cells, which die when separated from their original tissue, cancer cells can spread to other tissues where they invade and grow, in a process called metastasis. TGF-β1, a cytokine protein that functions as a signaling substance in the body, induces lung cancer metastasis and promotes the development of stem cell-like properties in cancer cells. The KIST research team treated lung cancer cells with Rk1 and Rg5, the main components of KMxG red ginseng and showed that both components effectively inhibited various processes related to cancer metastasis induced by TGF-β1.
"Although components of red ginseng previously have been shown to kill cancer cells, this study proved that these components of red ginseng have other anti-cancer effects and can inhibit lung cancer metastasis. This provides scientific evidence that may lead to the future development of anti-cancer drugs derived from natural products," remarked Dr. Ham. He added, "Because we can control the active ingredient contents of red ginseng by using microwave processing methods like the one that produced KMxG, it may be possible to develop customized functional materials for various diseases."
INFORMATION:
This study was conducted as part of a major program at KIST with financial support from the Ministry of Science and ICT (MSIT) and also supported by the nano-convergence industrial core technology development program funded by the Ministry of Trade, Industry, and Energy (MOTIE). The results of the study were published in a recent issue of 'Journal of Ginseng Research' an international journal in the field of ginseng research.
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2021-03-03
Researchers from the University of Texas, University of Chicago, University of Notre Dame, and London School of Economics published a new paper in the Journal of Marketing that examines whether entrepreneurs in emerging markets can benefit from marketers' help.
The study, forthcoming in the Journal of Marketing, is titled "Do Marketers Matter for Entrepreneurs? Evidence from a Field Experiment in Uganda" and is authored by Stephen Anderson, Pradeep Chintagunta, Frank Germann, and Naufel Vilcassim.
Can marketers help improve the world? While this question may seem vast and unknowable, this new study proposes ...
2021-03-03
BINGHAMTON, NY -- Customized diets and lifestyle changes could be key to optimizing mental health, according to new research including faculty at Binghamton University, State University of New York.
"There is increasing evidence that diet plays a major role in improving mental health, but everyone is talking about a healthy diet," said Begdache, an assistant professor of health and wellness studies at Binghamton University and co-author of a new paper in Nutrients.
"We need to consider a spectrum of dietary and lifestyle changes based on different age groups and gender," she said. "There is not one healthy diet that will work for everyone. There is not one fix."
Begdache, who is also a registered dietitian, believes that ...
2021-03-03
Home health visits change to virtual ones during pandemic
'We don't have to rely on mental health professionals'
As perinatal depression soars during pandemic, there's a growing need for treatment
CHICAGO --- Perinatal depression has soared during the pandemic. But many mental health professionals are overwhelmed and can't take on new clients.
Good news comes from a new Northwestern Medicine study finding paraprofessionals generated similar reductions in depressive symptoms as mental health professionals when delivering a group-based cognitive-behavioral therapy intervention.
The study findings are based on ...
2021-03-03
New research has revealed that the diets of early lizards and snakes, which lived alongside dinosaurs around 100 million years ago, were more varied and advanced than previously thought.
The study, led by the University of Bristol and published in Royal Society Open Science, showed lizards, snakes, and mosasaurs in the Cretaceous period already had the full spectrum of diet types, including flesh-eating and plant-based, which they have today.
There are currently some 10,000 species of lizards and snakes, known collectively as squamates. It was originally understood their great diversity was acquired only after the extinction ...
2021-03-03
Patients with type 2 diabetes that were treated with a weekly injection of the breakthrough drug Semaglutide were able to achieve an average weight loss of nearly 10kg, according to a new study published in The Lancet today.
Led by Melanie Davies, Professor of Diabetes Medicine at the University of Leicester and the Co-Director of the Leicester Diabetes Centre, the study showed that two thirds of patients with type 2 diabetes that were treated with weekly injections of a 2.4mg dose of Semaglutide were able to lose at least 5% of their body weight and achieved significant improvement in blood glucose control.
More than a quarter of patients were able to ...
2021-03-03
Pregnant patients in Colorado may be told about parenting and adoption, but not abortion. This is according to a new study led by Kate Coleman-Minahan of the University of Colorado College of Nursing published in the END ...
2021-03-02
Our brains are non-stop consumers. A labyrinth of blood vessels, stacked end-to-end comparable in length to the distance from San Diego to Berkeley, ensures a continuous flow of oxygen and sugar to keep our brains functioning at peak levels.
But how does this intricate system ensure that more active parts of the brain receive enough nourishment versus less demanding areas? That's a century-old problem in neuroscience that scientists at the University of California San Diego have helped answer in a newly published study.
Studying the brains of mice, a team of researchers led by Xiang Ji, David Kleinfeld and their colleagues has deciphered the question of brain energy consumption and blood vessel density through newly developed maps that detail ...
2021-03-02
When you think about your carbon footprint, what comes to mind? Driving and flying, probably. Perhaps home energy consumption or those daily Amazon deliveries. But what about watching Netflix or having Zoom meetings? Ever thought about the carbon footprint of the silicon chips inside your phone, smartwatch or the countless other devices inside your home?
Every aspect of modern computing, from the smallest chip to the largest data center comes with a carbon price tag. For the better part of a century, the tech industry and the field of computation ...
2021-03-02
Imagine you're driving up a hill toward a traffic light. The light is still green so you're tempted to accelerate to make it through the intersection before the light changes. Then, a device in your car receives a signal from the controller mounted on the intersection alerting you that the light will change in two seconds -- clearly not enough time to beat the light. You take your foot off the gas pedal and decelerate, saving on fuel. You feel safer, too, knowing you didn't run a red light and potentially cause a collision in the intersection.
Connected and automated vehicles, which can interact vehicle to vehicle (V2V) and between vehicles and roadway ...
2021-03-02
Type 2 diabetes, once considered an adult disease, is increasingly causing health complications among American youth. A research review published in the Journal of Osteopathic Medicine suggests physicians should work to more aggressively prevent pediatric diabetes.
Because few pediatric Type 2 diabetes treatment options are available, prevention is unusually important. To improve health outcomes, the paper's authors recommend physicians conduct regular screenings of children and adolescents, adopt a high level of suspicion, and intervene early and often with families who have children at risk for prediabetes and T2 diabetes.
"Pediatric type 2 diabetes is more progressive and aggressive than adult-onset Type 2 diabetes," ...
LAST 30 PRESS RELEASES:
[Press-News.org] A new effect of red ginseng: suppression of lung cancer metastasis
Development of KIST-maximized ginsenoside (KMxG) using a microwave processing method for ginseng that increase the trace amounts of Rk1 and Rg5. Ginsenosides Rk1 and Rg5 effectively inhibit the metastasis of lung cancer
