PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Second COVID-19 wave in Europe less lethal than first wave

Applied mathematics methods used to study mortality rates of multiple waves of COVID-19

Second COVID-19 wave in Europe less lethal than first wave
2021-03-16
(Press-News.org) WASHINGTON, March 16, 2021 -- As Europe experienced its enormous second wave of the COVID-19 disease, researchers noticed the mortality rate -- progression from cases to deaths -- was much lower than during the first wave.

This inspired researchers from the University of Sydney and Tsinghua University to study and quantify the mortality rate on a country-by-country basis to determine how much the mortality rate from the second wave decreased from the first.

In Chaos, by AIP Publishing, Nick James, Max Menzies, and Peter Radchenko introduce methods to study the progression of COVID-19 cases to deaths during the pandemic's different waves. Their methods involve applied mathematics, specifically nonlinear dynamics, and time series analysis.

"We take a time series, apply an algorithmic approach to chop it up into first and later waves, and do some relatively simple optimization and calculations to determine two different mortality numbers," said James, from the University of Sydney.

The mortality rate of the massive European second wave turned out to be much less severe -- at least with respect to reported cases and deaths. But how much less severe and how did it differ between countries?

"We think answering these questions is important, and to answer this for all of Europe, not just the wealthier Western countries," said Menzies, from Tsinghua University. "In Belarus, for example, the mortality rate actually increased during its second wave, while Ukraine and Moldova were still in their first wave as of the end of November."

The researchers discovered this was very different from the Netherlands, Belgium, France, and other countries that drastically reduced their mortality rates -- at least with respect to reported numbers -- between their first and second waves.

"Our work shows sharp drops in mortality with respect to reported cases and deaths," Menzies said. "The problem will always be, what is the true number of cases in the early first wave? We may never know, but we imagine future research and analysis will try to determine it."

When the researchers reran their analysis on estimated true cases and estimated deaths, Radchenko, from the University of Sydney, pointed out that those measures show serious limitations.

"Excess mortality is often negative relative to previous years, so it's unsuitable for measuring the true numbers of COVID-19 deaths," Radchenko said. "We hope others will more closely analyze the true numbers, perhaps using more specialized data such as out of particular hospitals or regions where testing was more reliable."

Broad similarity was also observed between Europe and the U.S., where Northeastern states behaved similarly to wealthy Western European countries in their sharp reductions of mortality during the second wave.

INFORMATION:

The article "COVID-19 second wave mortality in Europe and the United States" is authored by Nick James, Max Menzies, and Peter Radchenko. It will appear in Chaos on Mar. 16, 2021 (DOI: 10.1063/5.0041569). After that date, it can be accessed at https://aip.scitation.org/doi/10.1063/5.0041569.

ABOUT THE JOURNAL

Chaos is devoted to increasing the understanding of nonlinear phenomena in all areas of science and engineering and describing their manifestations in a manner comprehensible to researchers from a broad spectrum of disciplines. See https://aip.scitation.org/journal/cha.


[Attachments] See images for this press release:
Second COVID-19 wave in Europe less lethal than first wave

ELSE PRESS RELEASES FROM THIS DATE:

Crying human tear glands grown in the lab

2021-03-16
Researchers from the lab of Hans Clevers (Hubrecht Institute) and the UMC Utrecht used organoid technology to grow miniature human tear glands that actually cry. The organoids serve as a model to study how certain cells in the human tear gland produce tears or fail to do so. Scientists everywhere can use the model to identify new treatment options for patients with tear gland disorders, such as dry eye disease. Hopefully in the future, the organoids can even be transplanted into patients with non-functioning tear glands. The results will be published in Cell Stem Cell on the 16th of March. The tear gland is located in the upper part of the eye socket. It secretes tear fluid, which is essential for lubrication and nutrition of the cornea and has antibacterial components. Rachel Kalmann ...

Squishy white blood cells quickly become highly stiff and viscous in response to a threat

2021-03-16
Like a well-trained soldier, a white blood cell uses specialized abilities to identify and ultimately destroy dangerous intruders, including creating a protrusion to effectively reach out, lock-on, probe, and possibly attack its prey. Researchers reporting March 16 in Biophysical Journal show in detail that these cells take seconds to morph into these highly rigid and viscous defensive units. Senior author Julien Husson (@_julienhusson), a biophysicist at École Polytechnique near Paris, and collaborators showed previously that certain white blood cells, called T cells, ...

Brain disease research reveals differences between sexes

Brain disease research reveals differences between sexes
2021-03-16
WASHINGTON, March 16, 2021 -- Men and women are impacted differently by brain diseases, like Alzheimer's disease and Parkinson's disease. Researchers are urging their colleagues to remember those differences when researching treatments and cures. In APL Bioengineering, by AIP Publishing, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. That is progress from just a few years ago, said Alisa Morss ...

Tear glands in a dish can cry

2021-03-16
Stem-cell-derived organoids that swell up with tears could shed light on the biology of crying and dry-eye disease, suggests a study publishing March 16 in the journal Cell Stem Cell. Although regenerative therapies using human tear-gland organoids will not be possible anytime soon, these researchers have demonstrated that the organoids can engraft, integrate, and produce mature tear products upon transplantation into mouse tear glands. "We hope that scientists will use our model to identify new treatment options for patients with tear-gland disorders by either testing new drugs on a patient's organoids or expanding healthy cells and, one day, using them for transplantation," says senior study author Hans Clevers (@HansClevers) of the Hubrecht Institute. The ...

Second-wave COVID mortality dropped markedly in (most) wealthier zones

Second-wave COVID mortality dropped markedly in (most) wealthier zones
2021-03-16
Wealthier northeastern US states and Western European countries tended to have significantly lower mortality rates during second-wave COVID-19 infections, new research from the University of Sydney and Tsinghua University has shown. However, the pattern was not as general as expected, with notable exceptions to this trend in Sweden and Germany. Researchers say mortality change could have several explanations: European first-wave case counts were underestimated; First-wave deaths disproportionately affected the elderly; Second-wave infections tended to affect younger people; With some ...

Machine learning can identify cancerous cells by their acidity

Machine learning can identify cancerous cells by their acidity
2021-03-16
WASHINGTON, March 16, 2021 -- Cancerous cells exhibit several key differences from healthy cells that help identify them as dangerous. For instance, the pH -- the level of acidity -- within a cancerous cell is not the same as the pH within a healthy cell. Researchers from the National University of Singapore developed a method of using machine learning to determine whether a single cell is cancerous by detecting its pH. They describe their work in the journal APL Bioengineering, from AIP Publishing. "The ability to identify single cells has acquired a paramount importance in the field of precision and personalized medicine," ...

Seroprevalence of SARS-CoV-2 antibodies in US adult asymptomatic population

2021-03-16
What The Study Did: The findings of this study suggest that, based on a sample from an otherwise healthy population, the overall number of SARS-CoV-2 infections in the U.S. may be substantially higher than estimates based on public health case reporting. Authors: Robert L. Stout, Ph.D., of Clinical Reference Laboratory Inc. in Lenexa, Kansas, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1552) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

Nursing home characteristics associated with resident COVID-19 morbidity in communities with high infection rates

2021-03-16
What The Study Did: Researchers examined nursing homes in communities with the highest COVID-19 prevalence to identify characteristics associated with resident infection rates. Authors: Hye-Young Jung, Ph.D., of Weill Cornell Medical College in New York, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1555) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including ...

Viruses adapt to 'language of human cells' to hijack protein synthesis

Viruses adapt to language of human cells to hijack protein synthesis
2021-03-16
The first systematic study of its kind describes how human viruses including SARS-CoV-2 are better adapted to infecting certain types of tissues based on their ability to hijack cellular machinery and protein synthesis. Carried out by researchers at the Centre for Genomic Regulation (CRG), the findings could help the design of more effective antiviral treatments, gene therapies and vaccines. The study is published today in the journal Cell Reports. Living organisms make proteins inside their cells. Each protein consists of single units of amino acids which are stitched together according to instructions encoded within DNA. The basic units of these instructions are known as a codons, each of which corresponds ...

Embryonic tissue undergoes phase transition

2021-03-16
When scientists at the Institute of Science and Technology (IST) Austria looked at developing zebrafish embryos, they observed an abrupt and dramatic change: within just a few minutes, the solid-like embryonic tissue becomes fluid-like. What could cause this change and, what is its role in the further development of the embryo? In a multidisciplinary study published in the journal Cell, they found answers that could change how we look at key processes in development and disease, such as tumor metastasis. To learn more about how a tiny bunch of cells develops into complex systems ...

LAST 30 PRESS RELEASES:

Concern over harmful medical advice from social media influencers

Telling women as part of mammography screening that they have dense breasts may have unintended effects

Note- taking alone or combined with large language models helps students understand and remember better than large language models alone

Astronomers spot one of the largest spinning structures ever found in the Universe

Retinal organoid platform identifies biomarkers and affords genetic testing for retinal disease 

New roadmap reveals how everyday chemicals and microbes interact to fuel antimicrobial resistance

Scientists clarify how much metal in soil is “too much” for people and the environment​

Breakthrough pediatric kidney therapy emerges from U. Iowa research

Breakthrough iron-based magnetic material achieves major reduction in core loss

New design tackles heat challenges in high-power fiber lasers

Rapid fabrication of self-propelled, steerable magnetic microcatheters for precision medicine

Poor kidney health linked to higher levels of Alzheimer’s biomarkers in blood

A metamaterial that bridges air and water

Evaluating building materials for climate impact and noise suppression

Scores of dinosaurs walked and swam along a Bolivian shoreline

Captive bottlenose dolphins vary vocalizations during enrichment activities

Adults who want children favor older-looking partners (but not for their money), study suggests

Authoritative parenting styles are associated with better mental health and self-esteem among adolescents, while authoritarian parenting styles are associated with depression and lower self-esteem and

A rose by any other name? Not necessarily—how words sound aesthetically correlates with their memorability, study finds

The odds of iron deficiency in adolescent girls are almost 14 times higher among those who experience heavy menstruation and follow a meat-restricted diet, compared to girls with normal menstruation w

Sperm tails and male infertility: Critical protein revealed by ultrastructure microscope

Bumblebees launch a three-stage defensive response when their nest is disturbed

Experimental drug repairs DNA damage caused by disease

Study shows common childhood virus can drive bladder cancer development

New test distinguishes vaccine-induced false positives from active HIV infection

Becoming human in southern Africa: What ancient hunter-gatherer genomes reveal

The transformation of adult heart transplantation in the United States and Western Europe

American Physical Society launches APS Open Science to expand global participation in trusted physics research

Family dogs boost adolescent mental health through the microbiome

Prehab can improve recovery after surgery, but barriers remain

[Press-News.org] Second COVID-19 wave in Europe less lethal than first wave
Applied mathematics methods used to study mortality rates of multiple waves of COVID-19