PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Double duty: Gut's immune system helps regulate food processing, too

2021-03-18
(Press-News.org) The small intestine is ground zero for survival of animals. It is responsible for absorbing the nutrients crucial to life and it wards off toxic chemicals and life-threatening bacteria.

In a new study published March 18 in the journal Science, Yale researchers report the critical role played by the gut's immune system in these key processes. The immune system, they found, not only defends against pathogens but regulates which nutrients are taken in.

The findings may provide insights into origins of metabolic disease and malnutrition that is common in some undeveloped regions of the world.

"We were surprised that the immune system was so involved in nutrition," said first author Zuri Sullivan, a former graduate student in the immunology department at Yale and now a Howard Hughes Medical Institute Hanna H. Gray postdoctoral fellow at Harvard. "And the study lays the groundwork for understanding how this reciprocal interaction works."

Working in the lab of senior author Ruslan Medzhitov, Yale's Sterling Professor of Immunobiology and an investigator at the Howard Hughes Medical Institute, Sullivan became interested in how the diets of humans and other animals can dramatically change the organization of their digestive tracts. For instance, the digestive systems of carnivores and herbivores are organized differently to accommodate their specialized diets. Omnivores have the most complex system, which must adapt to a diverse diet of proteins, fats, and carbohydrates depending upon what's available in the environment.

Sullivan, Medzhitov, and a group of colleagues decided to study how the large numbers of immune cells present inside intestinal tracts might influence nutrition. For instance, a specific immune system signaling molecule, known as interleukin-22 (IL-22), plays a key role in combatting bacterial pathogens such as those that cause food poisoning. The presence of IL-22 also seems to prevent the uptake of certain nutrients in the digestive system when pathogens are present.

In a series of experiments, the researchers discovered that a specific group of immune system cells -- gamma delta T cells -- can suppress expression of interleukin-22 in mice and allow the cells on the intestinal wall to activate digestive enzymes and nutrient transporters.

In addition to providing insights into malnutrition in some parts of the world -- where bacterial infections lead to chronic expression of IL-22 and suppress the uptake of nutrients. The findings might also eventually help researchers develop ways to combat high rates of metabolic diseases, such as Type 2 diabetes and obesity in the developed world, Sullivan said.

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Discovery of a 'winged' shark in the Cretaceous seas

Discovery of a winged shark in the Cretaceous seas
2021-03-18
93 million years ago, bizarre, winged sharks swam in the waters of the Gulf of Mexico. This newly described fossil species, called Aquilolamna milarcae, has allowed its discoverers to erect a new family. Like manta rays, these 'eagle sharks' are characterised by extremely long and thin pectoral fins reminiscent of wings. The specimen studied was 1.65 metres long and had a span of 1.90 metres. Aquilolamna milarcae had a caudal fin with a well-developed superior lobe, typical of most pelagic sharks, such as whale sharks and tiger sharks. Thus, its anatomical features thus ...

How bushfire smoke traveled around the world

2021-03-18
It's not just how hot the fires burn - it's also where they burn that matters. During the recent extreme fire season in Australia, which began in 2019 and burned into 2020, millions of tons of smoke particles were released into the atmosphere. Most of those particles followed a typical pattern, settling to the ground after a day or week; yet the ones created in fires burning in one corner of the country managed to blanket the entire Southern hemisphere for months. A pair of Israeli scientists managed to track puzzling January and February 2020 spikes in a measure of particle-laden haze to those fires, and then, in a paper recently published in Science, they ...

Self-compassion can lessen feelings of work-from-home loneliness, finds study

2021-03-18
INDIANAPOLIS -- The ongoing COVID-19 pandemic is keeping millions of Americans from their usual offices, as they find themselves still working at home. Even with the vaccine now being distributed, working from home may still be the future for some, and new research suggests the resulting work loneliness negatively impacts employee well-being. ...

Estimating the timing of the earliest SARS-CoV-2 case in Hubei Province, China

2021-03-18
Researchers who simulated early stages of the SARS-CoV-2 outbreak in Wuhan, China, conclude that the virus was likely circulating earlier than has been described, possibly even in mid-October 2019. The findings do not reveal whether the virus that first emerged was less "fit" than the virus that spread throughout China, say the authors, but the estimates do further distance the first ("index") case from the outbreak at the Huanan Seafood Wholesale Market, which has received much attention. A concerted effort has been made to determine when the SARS-CoV-2 virus ...

Could leak in blood-brain barrier be cause of poor memory?

2021-03-18
Have you forgotten where you laid your keys? Ever wondered where you had parked your car? Or having trouble remembering the name of the new neighbor? Unfortunately, these things seem to get worse as one gets older. A big question for researchers is where does benign forgetfulness end and true disease begin? One of the keys to having a healthy brain at any age is having a healthy blood-brain barrier, a complex interface of blood vessels that run through the brain. Researchers reviewed more than 150 articles to look at what happens to the blood-brain barrier as we age. Their findings were published March 15 in Nature ...

New perovskite fabrication method for solar cells paves way to large-scale production

New perovskite fabrication method for solar cells paves way to large-scale production
2021-03-18
LOS ALAMOS, N.M., March 18, 2021--A new, simpler solution process for fabricating stable perovskite solar cells overcomes the key bottleneck to large-scale production and commercialization of this promising renewable-energy technology, which has remained tantalizingly out of reach for more than a decade. "Our work paves the way for low-cost, high-throughput commercial-scale production of large-scale solar modules in the near future," said Wanyi Nie, a research scientist fellow in the Center of Integrated Nanotechnologies at Los Alamos National Laboratory and corresponding ...

'Vulnerable' countries experience lower COVID-19 infection and death rates than the norm

Vulnerable countries experience lower COVID-19 infection and death rates than the norm
2021-03-18
During a pandemic like COVID-19, vulnerable countries are traditionally the focus of global attention and concern. However, new research suggests that we need to rebuild our understanding. A study published in KeAi's Global Health Journal, examined the relationship between state vulnerabilities (measured using the Fragile States Index (FSI) from Fund for Peace) and COVID-19 incidence and death rates in 146 countries. The FSI consists of 12 specific indicators covering cohesion, economy, politics and society. "When using the total FSI score for statistical analysis, we were surprised to find that, overall, the more fragile countries had lower cumulative incidence and fatality rates for COVID-19," explains one of the study's authors, Yangmu ...

Reversing cancer's gluttony

Reversing cancers gluttony
2021-03-18
In new findings published online March 18, 2021 in the journal Cancer Cell, an international team of researchers, led by scientists at University of California San Diego School of Medicine and Moores Cancer Center, describe how pancreatic cancer cells use an alternative method to find necessary nutrients, defying current therapies, to help them grow and spread. Pancreatic cancer accounts for roughly 3 percent of all cancers in the United States, but it is among the most aggressive and deadly, resulting in 7 percent of all cancer deaths annually. Pancreatic cancer is especially deadly once it metastasizes, with the number of people who are alive five years later declining from 37 percent to just 3 percent. All cancer cells require a constant supply of nutrients. Some types ...

New material: Rapid color change

2021-03-18
Smart glass can change its color quickly through electricity. A new material developed by chemists of Ludwig-Maximilians-Universität (LMU) in Munich has now set a speed record for such a change. On the highway at night. It rains, the bright headlights of the car behind you are blinding. How convenient to have an automatically dimming rearview mirror in such a case. Technically, this helpful extra is based on electrochromic materials. When a voltage is applied, their light absorption and color change. Controlled by a light sensor, the rearview mirror can thus filter out strongly dazzling light. Recently, experts discovered that, in addition to established inorganic electrochromic materials, a new generation of highly ordered lattice structures can also be equipped ...

Using conservation criminology to understand restaurant's role in urban wild meat trade

Using conservation criminology to understand restaurants role in urban wild meat trade
2021-03-18
KINSHASA, DEMOCRATIC REPUBLIC OF CONGO (March 18, 2021) - A new study in the journal Conservation Science and Practice finds that restaurants in urban areas in Central Africa play a key role in whether protected wildlife winds up on the menu. The study, by a team of scientists from Michigan State University, Wildlife Conservation Society (WCS), and University of Maryland, used a crime science "hot product" approach, which looks at frequently stolen items coveted by thieves. The approach offered new insights into wildlife targeted by the urban wild meat trade and can inform urban wildlife policies. The study engaged lower, middle, and upper-level tiered restaurants to understand which species were traded. ...

LAST 30 PRESS RELEASES:

Underserved youth less likely to visit emergency department for concussion in Ontario, study finds

‘Molecular shield’ placed in the nose may soon treat common hay fever trigger

Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂

Groundbreaking quantum study puts wave-particle duality to work

Weekly injection could be life changing for Parkinson’s patients

Toxic metals linked to impaired growth in infants in Guatemala

Being consistently physically active in adulthood linked to 30–40% lower risk of death

Nerve pain drug gabapentin linked to increased dementia, cognitive impairment risks

Children’s social care involvement common to nearly third of UK mums who died during perinatal period

‘Support, not judgement’: Study explores links between children’s social care involvement and maternal deaths

Ethnic minority and poorer children more likely to die in intensive care

Major progress in fertility preservation after treatment for cancer of the lymphatic system

Fewer complications after additional ultrasound in pregnant women who feel less fetal movement

Environmental impact of common pesticides seriously underestimated

The Milky Way could be teeming with more satellite galaxies than previously thought

New study reveals surprising reproductive secrets of a cricket-hunting parasitoid fly

Media Tip Sheet: Symposia at ESA2025

NSF CAREER Award will power UVA engineer’s research to improve drug purification

Tiny parasitoid flies show how early-life competition shapes adult success

New coating for glass promises energy-saving windows

Green spaces boost children’s cognitive skills and strengthen family well-being

Ancient trees dying faster than expected in Eastern Oregon

Study findings help hone precision of proven CVD risk tool

Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later

Introducing BioEmu: A generative AI Model that enables high-speed and accurate prediction of protein structural ensembles

Replacing mutated microglia with healthy microglia halts progression of genetic neurological disease in mice and humans

New research shows how tropical plants manage rival insect tenants by giving them separate ‘flats’

Condo-style living helps keep the peace inside these ant plants

Climate change action could dramatically limit rising UK heatwave deaths

Annual heat-related deaths projected to increase significantly due to climate and population change

[Press-News.org] Double duty: Gut's immune system helps regulate food processing, too