PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Memory and executive function symptoms more accurate for predicting CTE than mood, behavior

Another step closer to being able to diagnose CTE in the living

2021-04-07
(Press-News.org) (Boston)--Diagnosing Chronic Traumatic Encephalopathy (CTE) during life is crucial for developing therapies and for determining how common the disease is among individuals exposed to repetitive head impacts from contact sports, military service and physical violence.

While the ability to diagnose CTE prior to death has remained elusive, researchers from Boston University School of Medicine (BUSM) for the first time have shown that progressive memory loss and issues with executive function, the ability to focus, follow directions, and problem-solve, are more useful for predicting CTE pathology than mood and behavior symptoms.

CTE is a progressive brain disease. Clinically, impulsivity, explosivity, depression, memory impairment and executive dysfunction have been reported to occur in the disease.

"This study significantly advances our understanding of how to diagnose CTE in life, suggesting progressive memory and executive function symptoms are particularly valuable for predicting CTE pathology," explained corresponding author Jesse Mez, MD, MS, director of the Boston University (BU) Alzheimer's Disease Center Clinical Core and a BU CTE Center Investigator.

In 2014, criteria for traumatic encephalopathy syndrome (TES) were proposed for use in clinical research settings to diagnose CTE in life. In an effort to assess the reliability and diagnostic validity of TES criteria, a team of clinicians interviewed family members of 336 brain donors exposed to repetitive head impacts from contact sports, military service and/or physical violence who were at risk for CTE. Neuropathologists then evaluated the brains for CTE pathology. An expert panel of clinicians then determined whether (TES) criteria (i.e. proposed criteria to diagnose CTE in life) were met. They found when individual TES criteria components were assessed, cognitive symptoms, but not mood/behavior or motor symptoms, were significantly associated with CTE pathology.

According to Mez, this study moves the field closer to being able to diagnose CTE in life rather than exclusively after death, as is currently the case. "Our study provides doctors with information about which symptoms are most predictive of CTE pathology," he adds.

While having reliable and valid criteria to diagnose CTE in life will improve patient care and accelerate the development of effective therapies, Mez points out that the criteria did not perform well enough to be immediately moved to the clinic. However, these findings were used by an international team of experts to develop improved TES criteria.

INFORMATION:

These findings appear online in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

This work was supported by the National Institute of Neurological Disorders and Stroke (U01NS086659, U01NS093334, U54NS115266, R01NS078337, R56NS078337, K23NS102399), National Institute of Aging (P30AG13846; supplement 0572063345, R01AG057902, R01AG061028, K23AG046377, R01AG1649, R01AG062348, R21HD089088, F32NS096803), National Center for Advancing Translational Sciences (1UL1TR001430), Department of Veterans Affairs (I01 CX001135, CSP 501, B6796-C, I01CX001038), Department of Defense (W81XWH-13-2-0095, W81XWH-13-2-0064, W81XWH1810580, PRARP-13267017), Canadian Institutes of Health Research (CIHR), Fonds de Recherche du Québec - Santé (FRQS), the Alzheimer's Association (NIRG-15-362697, NIRG-305779), the National Operating Committee on Standards for Athletic Equipment (NOCSAE), the Nick and Lynn Buoniconti Foundation, the Concussion Legacy Foundation, the Andlinger Foundation, the WWE, and the NFL.

Note to Editors: Dr. Goldstein is a paid consultant to Johnson & Johnson, Janssen Research & Development LLC, and Rebiscan Inc and has received funding from the WWE (World Wrestling Entertainment) and Ivivi Health Sciences.

Dr. Nowinski is the Co-Founder and Chief Executive Officer of the Concussion Legacy Foundation, and serves as an advisor for Oxeia Biopharmaceuticals.

Dr. Stern is a paid consultant to Biogen, is a member of the Mackey-White Health and Safety Committee of the National Football League Players Association, receives royalties for published neuropsychological tests from Psychological Assessment Resources Inc, is a member of the Board of Directors of King-Devick Technologies, and reported grants from the National Institutes of Health during the conduct of the study.

Dr. Cantu is a paid consultant to the National Football League Head Neck and Spine Committee, a vice president and chair of the scientific advisory committee of the National Operating Committee on Standards for Athletic Equipment, and a consultant to the Concussion Legacy Foundation; he also receives royalties from Houghton Mifflin Harcourt and compensation for expert legal opinion to the National Collegiate Athletic Association and National Hockey League and is a member of the Mackey-White Committee of the National Football League Players Association.

Dr. McKee is a member of the Mackey-White Committee of the National Football League Players Association and reports receiving grants from the National Institutes of Health and Department of Veteran Affairs and other funding from Buoniconti Foundation during the conduct of the study.

Dr. Alosco reported grants from National Institutes of Health/National Institute of Neurological Disorders and Stroke during the conduct of the study.

Dr. Katz reported grants from Boston University School of Medicine Department of Neurology during the conduct of the study, receives royalties from Springer/Demos Publishing for a text book on brain injury, serves as an expert witness in legal cases involving brain injury and concussion; receives a stipend from Encompass Health as program medical director for brain injury and chair of the annual Neurorehabilitation conference; has received honoraria for a keynote address for the HealthSouth annual Medical Directors meeting.

Dr. Mez reported grants from the National Institutes of Health, Department of Defense, Alzheimer's Association, and Concussion Legacy Foundation during the conduct of the study.



ELSE PRESS RELEASES FROM THIS DATE:

An amyloid link between Parkinson's disease and melanoma

An amyloid link between Parkinsons disease and melanoma
2021-04-07
WASHINGTON, April 7, 2021 -- On the surface, Parkinson's disease -- a neurodegenerative disorder -- and melanoma -- a type of skin cancer -- do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link between the two diseases in the form of protein aggregates known as amyloids. The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2021 is being held online April 5-30. Live sessions will be hosted April ...

Comfort care beneficial for hospitalized stroke patients, yet disparities in use persist

2021-04-07
DALLAS, April 7, 2021 — Receiving palliative or hospice care services was found to improve quality of life for hospitalized ischemic stroke patients, however, disparities persist in which patients are prescribed or have access to these holistic comfort care options, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association. Prior to the COVID-19 pandemic, stroke ranked No. 5 among all causes of death in the U.S. Nearly 9 in 10 strokes are ischemic strokes caused by a blockage in a blood vessel that carries blood to the brain. Despite advances in acute stroke treatment and management, stroke remains a leading cause of serious long-term disability in the U.S. “Stroke ...

Skoltech scientists create a new electronegativity scale

2021-04-07
Skoltech chemists have proposed a new electronegativity scale and published their findings in Nature Communications. The concept of electronegativity introduced by Linus Pauling, a great American chemist, in the 1930s refers to the ability of an atom to attract electron density. In a chemical bond, the more electronegative atom gains extra electrons, becoming negatively charged, while the less electronegative one loses electrons and becomes positively charged. Electronegativity is a fundamental notion, essential for explaining things that range from chemical bonds' energy to the (in)stability of chemical compounds and the color and hardness of crystals. Since then, chemists have come up with various definitions and scales of electronegativity. Yet Pauling's ...

The future of biodiversity collections

2021-04-07
Events such as the COVID-19 pandemic have highlighted the crucial role played by biodiversity collections in enabling rapid responses to crises and in facilitating ongoing research across numerous fields. Despite the recognized value of this infrastructure, the community nevertheless has further opportunities to maximize its value to the scientific enterprise. Writing in BioScience, Barbara Thiers of the New York Botanical Garden and colleagues describe (https://academic.oup.com/bioscience/article-lookup/doi/10.1093/biosci/biab036) the necessary steps for the biodiversity collections community to vouchsafe its position as an important catalyst of research. The authors draw on recommendations ...

We don't know how most mammals will respond to climate change, warn scientists

2021-04-07
A new scientific review has found there are significant gaps in our knowledge of how mammal populations are responding to climate change, particularly in regions most sensitive to climate change. The findings are published in the British Ecological Society's Journal of Animal Ecology. Nearly 25% of mammal species are threatened with extinction, with this risk exacerbated by climate change. But the ways climate change is impacting animals now, and projected to in the future, is known to be complex. Different environmental changes have multiple and potentially contrasting, ...

Family child care home providers with high diet self-efficacy are better equipped to manage stress

2021-04-07
Philadelphia, April 7, 2021 - Building family child care home providers' (FCCH) self-efficacy--an individual's belief in their ability to manage their situation--for healthy eating is an important component of health promotion and can buffer the impact of stress on their diet quality, according to a new study in the Journal of Nutrition Education and Behavior, published by Elsevier. "The FCCH provider is an important source of child care in this country. A lot of families from lower-income environments use the FCCH because of its affordability and location," said Dianne Ward, EdD, of the Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. FCCH providers can experience multiple stressors ...

Poor children are 'failed by system' on road to higher education in lower-income countries

2021-04-07
A generation of talented but disadvantaged children are being denied access to higher education because academic success in lower and middle-income countries is continually 'protected by wealth', a study has found. The research, which used data from around 3,500 young people in Ethiopia, India, Peru and Vietnam, shows that promising but poorer students 'fall away' during their school years, as challenges associated with their socio-economic circumstances gradually erode their potential. Among children who showed similar levels of ability aged 8, for example, the wealthiest were often over 30 percentage points more likely than the least-wealthy to enter all forms of tertiary education: including university, technical colleges, and teacher training. Even ...

Are early treatments for cerebral palsy effective?

2021-04-07
Symptoms of cerebral palsy, a neurological disorder that affects a person's ability to move and maintain balance and posture, appear early during childhood. A new analysis examines the effectiveness of therapies initiated from birth until 3 years of age for children with or at risk for cerebral palsy. The analysis, which is published in Developmental Medicine & Child Neurology, included all systematic reviews from 2009-2020 that assessed the results of relevant published studies. Investigators concluded that research has generated limited supportive data and cannot yet confirm a greater benefit from early versus later interventions; however, earlier, ...

Program may help patients with rheumatic diseases quit smoking

2021-04-07
Smoking increases symptoms and health risks for patients with rheumatic diseases, but interventions to help patients quit are rarely available at rheumatology clinics. A study published in Arthritis Care & Research has found that Quit Connect--a protocol involving electronic health record prompts for nurses and medical assistants in rheumatology clinics--can increase electronic referrals to free, state-run tobacco quite lines. Implementing Quit Connect led to electronic referrals for 71% of patients who were identified as ready to quit, with referrals taking less than 90 seconds for medical staff to complete. "There's a huge opportunity to address smoking as a modifiable risk factor in rheumatology patients, and Quit Connect was 26-times more effective than usual care for ...

Do school-based interventions help improve reading and math in at-risk children?

2021-04-07
School-based interventions that target students with, or at risk of, academic difficulties in kindergarten to grade 6 have positive effects on reading and mathematics, according to an article published in END ...

LAST 30 PRESS RELEASES:

Heart patients advised to move more to avoid heart attacks and strokes

New amphibious centipede species discovered in Okinawa and Taiwan

Scientists may detect signs of extraterrestrial life in the next 5 to 10 years

The fate of the planet

Tarantula's ubiquity traced back to the cretaceous

On the pulse of pulsars and polar light

Neural plasticity depends on this long noncoding RNA's journey from nucleus to synapse

A new guide for communicating plant science

The future of particle accelerators is here

Simulations reveal how dominant SARS-CoV-2 strain binds to host, succumbs to antibodies

New understanding of the deleterious immune response in rheumatoid arthritis

The Trojan-Horse mechanism: How networks reduce gender segregation

Science Advances publishes proteomics technology from Oblique Therapeutics AB

Female protective effect: Yale researchers find clues to sex differences in autism

Researchers revise indicator of mobility limitation in older adults

Study shows past COVID-19 infection doesn't fully protect young people against reinfection

A new super-Earth detected orbiting a red dwarf star

Differences in national food security best explained by household income, not agriculture

Hidden magma pools pose eruption risks that we can't yet detect

COVID-19: Scientists identify human genes that fight infection

New CRISPR technology offers unrivaled control of epigenetic inheritance

How tangled proteins kill brain cells, promote Alzheimer's, CTE

Fitted filtration efficiency of double masking during COVID-19 pandemic

Fit matters most when double masking to protect yourself from COVID-19

Thermoelectric material discovery sets stage for new forms of electric power in the future

Researchers develop microscopic theory of polymer gel

Studies suggest people with blood cancers may not be optimally protected after COVID-19 vaccination

Are our oil and gas pipelines safe during an earthquake?

Virtual humans are equal to real ones in helping people practice new leadership skills

Promising results from first-in-humans study of a novel PET radiopharmaceutical

[Press-News.org] Memory and executive function symptoms more accurate for predicting CTE than mood, behavior
Another step closer to being able to diagnose CTE in the living