PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

One in four children want better pain treatment

Inselspital (University Hospital of Bern) and the University of Bern have conducted a major study on pain treatment in children at twelve centers in four European countries; analysis of the data revealed a need for optimization in nearly one in four child

2021-04-08
(Press-News.org) A great need for better pain treatment After an appendectomy, a quarter (24.8%) of all children wanted a stronger pain treatment in the first 24 hours after their operation. Among children who had a tonsillectomy, this was one-fifth (20.2%). Analysis of the data showed that this desire was primarily associated with sleep impairments and with movement pain. The lead author of the study, Prof. Ulrike M. Stamer, explained: "We are dealing with a large number of affected patients. Appendectomies and tonsillectomies are the most common operations performed on children overall. Just under a quarter of these cases strongly signal a desire for improvement".

A comprehensive, multicentre study

This study is based on the international pain registry "PAIN OUT infant", which was established in 2015 to track the quality of postoperative pain management in children. The study included 472 children with appendectomies and 466 children with tonsillectomies. More pain-related impairments and side effects were reported in children who wanted a stronger pain treatment. They also received more opioids postoperatively (on average 81 versus 50 micrograms per kilogram of body weight).

Surprising result shows the way to optimisation

A surprising result emerged from the analysis of the survey data and a comparison with the medication used before and during the operations. It was found that children who had been given at least two different classes of non-opioid analgesics (NSAIDs, metamizole or paracetamol) as a precautionary measure were significantly less likely to ask for a stronger pain treatment when questioned 24 hours after surgery. Prof. Frank Stüber, head of the Department of Anesthesiology at Inselspital (University Hospital of Bern) is optimistic: "We have been able to identify a promising path with these study results. Precautionary administration of at least two different classes of non-opioid analgesics appears to be a way to reduce the use of higher doses of opioids after surgery".

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Moffitt investigators identify STING gene methylation allows melanoma to evade the immune system

2021-04-08
TAMPA, Fla. (April 8, 2021) -- A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. In a new article published in Proceedings of the National Academy of Sciences of the United States of America, Moffitt Cancer Center researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction. Several different mechanisms have been discovered ...

Endophytic fungi as promising producers of bioactive small molecules

Endophytic fungi as promising producers of bioactive small molecules
2021-04-08
Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites. However, this strain mainly produce rubratoxins alone with high yield in varied culture conditions, suggested most gene clusters are silent. Efforts for mining the cryptic gene clusters in P. dangeardii, including epigenetic regulation and one-strain-many-compounds (OSMAC) approach were failed probably due to the high yield of rubratoxins. A metabolic ...

Archaeologists uncover earliest evidence of domesticated dogs in Arabian Peninsula

Archaeologists uncover earliest evidence of domesticated dogs in Arabian Peninsula
2021-04-08
A team of archaeologists in north-west the Kingdom of Saudi Arabia has uncovered the earliest evidence of dog domestication by the region's ancient inhabitants. The discovery came from one of the projects in the large-scale archaeological surveys and excavations of the region commissioned by the Royal Commission for AlUla (RCU). The researchers found the dog's bones in a burial site that is one of the earliest monumental tombs identified in the Arabian Peninsula, roughly contemporary with such tombs already dated further north in the Levant. Evidence ...

The fastest one wins

2021-04-08
Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles--frameworks made of three rings that are joined at the edges--very selectively and with the desired spatial structure. As a research team reports in the journal Angewandte Chemie, the rates of the different steps of the reaction play a critical role. Indole derivates are widely distributed in nature; they are part of serotonin and melatonin, as well as many alkaloids--some of which are used as drugs, for example, as treatments for Parkinson's disease. Indole is an aromatic six-membered ring fused to a five-membered ring along one edge. The five-membered ring has a double bond and ...

'Bug brain soup' expands menu for scientists studying animal brains

Bug brain soup expands menu for scientists studying animal brains
2021-04-08
Using a surprisingly simple technique, researchers in the University of Arizona Department of Neuroscience have succeeded in approximating how many brain cells make up the brains of several species of bees, ants and wasps. The work revealed that certain species of bees have a higher density of brain cells than even some species of birds, whereas ants turned out to have fewer brain cells than originally expected. Published in the scientific journal Proceedings of the Royal Society B, the study marks the first time the new cell counting method has been applied to invertebrate animals and provides a robust and reproducible protocol for other research groups studying the brains of ...

Novel diarylamides as orally active diuretics targeting urea transporters

Novel diarylamides as orally active diuretics targeting urea transporters
2021-04-08
Discovery of novel diarylamides as orally active diuretics targeting urea transporters Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In this study the authors discovered a novel UT inhibitor with a diarylamide scaffold by high-throughput screening. Optimization of the inhibitor led to the identification of a promising preclinical candidate, N-[4-(acetylamino)phenyl]-5-nitrofuran-2-carboxamide ...

Complete chromosome 8 sequence reveals novel genes and disease risks

Complete chromosome 8 sequence reveals novel genes and disease risks
2021-04-08
The full assembly of human chromosome 8 is reported this week in Nature.  While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally. This linear assembly is a first for a human autosome - a chromosome not involved in sex determination. The entire sequence of chromosome 8 is 146,259,671 bases. The completed assembly fills in the gap of more than 3 million bases missing from the current reference genome.   The Nature paper is titled "The structure, function and evolution of a complete chromosome 8." One of several intriguing characteristics ...

Energy transmission by gold nanoparticles coupled to DNA structures

2021-04-08
Using DNA structures as scaffolds, Tim Liedl, a scientist of Ludwig-Maximilians-Universitaet (LMU) in Munich, has shown that precisely positioned gold nanoparticles can serve as efficient energy transmitters.  Since the inception of the field in 2006, laboratories around the world have been exploring the use of 'DNA origami' for the assembly of complex nanostructures. The method is based on DNA strands with defined sequences that interact via localized base pairing. "With the aid of short strands with appropriate sequences, we can connect specific regions of long DNA molecules together, rather like forming three-dimensional structures by folding a flat sheet of paper in certain ...

Living fossils: Microbe discovered in evolutionary stasis for millions of years

Living fossils: Microbe discovered in evolutionary stasis for millions of years
2021-04-08
It's like something out of science fiction. Research led by Bigelow Laboratory for Ocean Sciences has revealed that a group of microbes, which feed off chemical reactions triggered by radioactivity, have been at an evolutionary standstill for millions of years. The discovery could have significant implications for biotechnology applications and scientific understanding of microbial evolution. "This discovery shows that we must be careful when making assumptions about the speed of evolution and how we interpret the tree of life," said Eric Becraft, the lead author on the paper. "It is possible that some organisms go into an evolutionary ...

Acrylamide derivatives for the treatment of rheumatoid arthritis

Acrylamide derivatives for the treatment of rheumatoid arthritis
2021-04-08
Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). The authors designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structure-activity ...

LAST 30 PRESS RELEASES:

Genetic causes of cerebral palsy uncovered through whole-genome sequencing

Modesty and boastfulness – perception depends on usual performance

Do sweeteners increase your appetite? New evidence from randomised controlled trial says no 

Women with obesity do not need to gain weight during pregnancy, new study suggests

Individuals with multiple sclerosis face substantially greater risk of hospitalisation and death from COVID-19, despite high rates of vaccination

Study shows obesity in childhood associated with a more than doubling of risk of developing multiple sclerosis in early adulthood

Rice Emerging Scholars Program receives $2.5M NSF grant to boost STEM education

Virtual rehabilitation provides benefits for stroke recovery

Generative AI develops potential new drugs for antibiotic-resistant bacteria

Biofuels could help island nations survive a global catastrophe, study suggests

NJIT research team discovering how fluids behave in nanopores with NSF grant

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment

Social media use may help to empower plastic surgery patients

Q&A: How to train AI when you don't have enough data

Wayne State University researchers uncover potential treatment targets for Zika virus-related eye abnormalities

Discovering Van Gogh in the wild: scientists unveil a new gecko species

Small birds spice up the already diverse diet of spotted hyenas in Namibia

Imaging detects transient “hypoxic pockets” in the mouse brain

Dissolved organic matter could be used to track and improve the health of freshwaters

Indoor air quality standards in public buildings would boost health and economy, say international experts

Positive associations between premenstrual disorders and perinatal depression

New imaging method illuminates oxygen's journey in the brain

Researchers discover key gene for toxic alkaloid in barley

New approach to monitoring freshwater quality can identify sources of pollution, and predict their effects

Bidirectional link between premenstrual disorders and perinatal depression

Cell division quality control ‘stopwatch’ uncovered

Vaccine protects cattle from bovine tuberculosis, may eliminate disease

Andrew Siemion to receive the SETI Institute’s 2024 Drake Award

New study shows how the Crimean-Congo hemorrhagic fever virus enters our cells

Neoadjuvant chemotherapy proves effective for locally advanced penile squamous cell carcinoma

[Press-News.org] One in four children want better pain treatment
Inselspital (University Hospital of Bern) and the University of Bern have conducted a major study on pain treatment in children at twelve centers in four European countries; analysis of the data revealed a need for optimization in nearly one in four child