Worm infections leave African women more vulnerable to STIs
2021-04-14
(Press-News.org) Intestinal worm infections can leave women in sub-Saharan Africa more vulnerable to sexually-transmitted viral infections, a new study reveals.
The rate and severity of sexually-transmitted viral infections (STI) in the region are very high, as are those of worm infections, which when caught in the intestine can change immunity in other parts of the body.
Researchers at the Universities of Birmingham and Cape Town led an international team which discovered that intestinal worm infection can change vaginal immunity and increase the likelihood of Herpes simplex virus type 2 (HSV-2) infection - the main cause of genital herpes.
Publishing their findings today in Cell Host and Microbe, the research team also notes that worm infections significantly increase the death of tissue in the vagina (necrosis), which can result in gangrene.
However, the researchers found that they could prevent this worm-induced changes in HSV2 pathology by targeting a particular type of immune cell called eosinophils - suggesting that this pathology could be prevented or reduced by using existing drugs.
Co-author Dr. William Horsnell, from the Institute of Microbiology & Infection at the University of Birmingham and Institute of Infectious Disease and Molecular Medicine, University of Cape town commented: "Our work identifies for the first time how a worm infection can influence a very important viral STI. This is important for health workers and may help them to explain why STIs are more virulent in areas where worm infections are common.
"We show that worm infections that never colonise the vagina cause a strong change in vaginal immunity. Following a viral vaginal sexually transmitted infection the pathology caused by the virus is hugely increased. Research into STIs has, until now, largely neglected the role of worm infections in influencing the severity of these important diseases."
Rates and severity of sexually transmitted viral infections in sub-Saharan Africa are very high and are one of the world's leading causes of pathological disease. Worm infection rates are also very high in this region, but do not colonise the female reproductive tract.
"Our research shows that eosinophils can have a very important role to play in vaginal immunity - we hope that this discovery will boost efforts to understand how parasitic worm infection indirectly influence control of sexually transmitted infections," added Dr Horsnell.
The research was funded by DFG, Poliomyelitis Research Foundation, Marie Curie and National Research Foundation (South Africa). The research team is currently studying in West Africa (Togo) and South Africa how existing and past worm infections associate with risk of women having an STI.
INFORMATION:
For more information, interviews or a copy of the research paper, please contact Tony Moran, International Communications Manager, University of Birmingham on +44 (0)782 783 2312. For out-of-hours enquiries, please call +44 (0) 7789 921 165.
Notes for editors
* The University of Birmingham is ranked amongst the world's top 100 institutions. It was established by Queen Victoria in 1900 as Great Britain's first civic university, where students from all religions and backgrounds were accepted on an equal basis.
* 'Il4ra -independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology following HSV-2 infection' - William Horsnell et al is published in Cell Host and Microbe.
* The research team comprised of experts from: University of Birmingham; University of Cape Town, South Africa; University of Bonn, Germany; Norwegian University of Science and Technology, Norway; University of Liege, Belgium; CNRS, Orleans, France; and University of Lome, Togo.
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[Press-News.org] Worm infections leave African women more vulnerable to STIs
