PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Lundquist investigator Chang's study in JAMA Internal Medicine

For critically ill patients with advanced medical illnesses and poor prognoses, overuse of invasive ICU treatment may prolong suffering

Lundquist investigator Chang's study in JAMA Internal Medicine
2021-04-14
(Press-News.org) LOS ANGELES (April 13, 2021) -- The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues' study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - "Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments" - found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings. This intervention was associated with reductions in invasive ICU treatments that prolonged suffering without benefit for patients and their families.

"Invasive ICU treatments are frequently delivered to patients who have very little chance of benefit. This leads to prolonged suffering for our patients and their families. We believed that poor communication was one of the key causes for this problem. In our study, we found that training physicians to use time-limited trials of ICU treatments engages families to make decisions together with the physicians and reduces unnecessary ICU treatments." said Dr. Chang.

The published study can be assessed here.

INFORMATION:

JAMA doi: 10.1001/jamainternmed.2021.1000

Media Contact for The Lundquist Institute: Max Benavidez max.benavidez@lundquist.org 310-200-2682

About The Lundquist Institute: Research with reach The Lundquist Institute is an engine of innovation with a global reach and a 69-year reputation of improving and saving lives. With its new medical research building, its state-of-the-art incubator, "BioLabs at The Lundquist," existing laboratory and support infrastructure, and the development of a new 15-acre business tech park, The Lundquist Institute serves as a hub for the Los Angeles area's burgeoning biotech scene. The research institute has over 100 principal investigators (PhDs, MDs, and MD/PhDs) working on more than 600 research studies, including therapies for numerous, and often fatal orphan diseases.


[Attachments] See images for this press release:
Lundquist investigator Chang's study in JAMA Internal Medicine

ELSE PRESS RELEASES FROM THIS DATE:

Telescopes unite in unprecedented observations of famous black hole

2021-04-14
In April 2019, scientists released the first image of a black hole in galaxy M87 using the Event Horizon Telescope (EHT). However, that remarkable achievement was just the beginning of the science story to be told. Data from 19 observatories released today promise to give unparalleled insight into this black hole and the system it powers, and to improve tests of Einstein's General Theory of Relativity. "We knew that the first direct image of a black hole would be groundbreaking," says Kazuhiro Hada of the National Astronomical Observatory of Japan, a co-author of a new study published in The Astrophysical Journal Letters that ...

Climate change is making Indian monsoon seasons more chaotic

2021-04-14
If global warming continues unchecked, summer monsoon rainfall in India will become stronger and more erratic. This is the central finding of an analysis by a team of German researchers that compared more than 30 state-of-the-art climate models from all around the world. The study predicts more extremely wet years in the future - with potentially grave consequences for more than one billion people's well-being, economy, food systems and agriculture. "We have found robust evidence for an exponential dependence: For every degree Celsius of warming, monsoon rainfalls will likely increase by about 5%," says lead author Anja Katzenberger from the Potsdam-Institute ...

Ancient pottery reveals the first evidence for honey hunting in prehistoric West Africa

Ancient pottery reveals the first evidence for honey hunting in prehistoric West Africa
2021-04-14
A team of scientists, led by the University of Bristol, with colleagues from Goethe University, Frankfurt, has found the first evidence for ancient honey hunting, locked inside pottery fragments from prehistoric West Africa, dating back some 3,500 years ago. Honeybees are an iconic species, being the world's most important pollinator of food crops. Honeybee hive products, including beeswax, honey and pollen, used both for food and medicinal purposes, support livelihoods and provide sources of income for local communities across much of Africa, through both beekeeping ...

Toxic gas in rat brains shows potential for new dementia treatments

2021-04-14
A potential treatment for dementia and epilepsy could look to reduce the amounts of a toxic gas in the brain has been revealed in a new study using rat brain cells. The research published in Scientific Reports today [Wednesday 14 April] shows that treatments to reduce levels of hydrogen sulfide (H2S) in the brain may help to ward off damage caused by the gas. By testing rat brain cells, the team of scientists from the University of Reading, University of Leeds and John Hopkins University in the USA found that H2S is involved in blocking a key brain cell gateway ...

Indigenous land-use reduced catastrophic wildfires on the Fish Lake Plateau

Indigenous land-use reduced catastrophic wildfires on the Fish Lake Plateau
2021-04-14
If you were to visit the Great Basin and Colorado Plateau a thousand years ago, you'd find conditions remarkably familiar to the present. The climate was warm, but drier than today. There were large populations of Indigenous people known as the Fremont, a who hunted and grew crops in the area. With similar climate and moderate human activity, you might expect to see the types of wildfires that are now common to the American West: infrequent, gigantic and devastating. But you'd be wrong. In a new study led by the University of Utah, researchers found that ...

Is it possible to predict when a woman will enter menopause?

2021-04-14
CLEVELAND, Ohio (April 14, 2021)--Despite all the advances in medicine, some basic questions remain. For example, people cannot be told with any certainty how long they'll live. Nor can it be predicted exactly when a woman's childbearing years will end. However, a new study offers insights into factors that might predict a woman's age at natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). Factors that affect age at natural menopause are one of the most frequently studied topics in menopause-related research in recent decades, and with good reason. Knowing when a woman will enter menopause could be ...

Superbug killer: New nanotech destroys bacteria and fungal cells

Superbug killer: New nanotech destroys bacteria and fungal cells
2021-04-14
Researchers have developed a new superbug-destroying coating that could be used on wound dressings and implants to prevent and treat potentially deadly bacterial and fungal infections. The material is one of the thinnest antimicrobial coatings developed to date and is effective against a broad range of drug-resistant bacteria and fungal cells, while leaving human cells unharmed. Antibiotic resistance is a major global health threat, causing at least 700,000 deaths a year. Without the development of new antibacterial therapies, the death toll could rise to 10 million people a year by 2050, equating to $US100 trillion in health care costs. While the health burden of fungal infections is less recognised, globally they kill about ...

How nonprofits can drive more giving from their current donor base

2021-04-14
Researchers from University of Hawaii and Cornell University published a new paper in the Journal of Marketing that explores the challenges and opportunities with nonprofit fundraising to provide organizations with strategies they can use to increase sustainable giving and profitability. The study, forthcoming in the Journal of Marketing, is titled "Managing Members, Donors, and Member-Donors for Effective Non-profit Fundraising" and is authored by Sungjin Kim, Sachin Gupta, and Clarence Lee. Individual philanthropy is the primary funding source for many nonprofit organizations. A major challenge facing such organizations ...

Rapid decreases in resting heart rate from childhood to adulthood may indicate heart trouble ahead

Rapid decreases in resting heart rate from childhood to adulthood may indicate heart trouble ahead
2021-04-14
While a slow resting heart rate is generally considered a good thing, investigators have some of the first evidence that if that rate decreases rapidly as children move into young adulthood, it's an indicator that cardiovascular disease may be in their future. Medical College of Georgia investigators report a significant association between a faster decrease in resting heart rate from childhood to adulthood and a larger left ventricle, the heart's major pumping chamber, over a 21-year period in hundreds of individuals who were healthy at the start. The faster decrease in heart rate also was associated with a higher level of pressure inside the blood vessels of the body, which ...

Power of light and oxygen clears Alzheimer's disease protein in live mice

2021-04-14
A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids. Researchers injected the molecule directly into the brains of live mice with Alzheimer's disease and then used a specialized probe to shine light into their brains for 30 minutes each day for one week. Chemical analysis of the mouse brain tissue showed that the treatment significantly reduced amyloid protein. Results from additional ...

LAST 30 PRESS RELEASES:

Twenty years on, biodiversity struggles to take root in restored wetlands

Do embedded counseling services in veterinary education work? A new study says “yes.”

Discovery of unexpected collagen structure could ‘reshape biomedical research’

Changes in US primary care access and capabilities during the COVID-19 pandemic

Cardiometabolic trajectories preceding dementia in community-dwelling older individuals

Role of ELK3 in ferroptosis of rheumatoid arthritis fibroblast-like synoviocytes

Team of Prof. Woo Young Jang Department of Orthopedic Surgery, KU Anam Hospital wins the Best Paper Award from the Korean Musculoskeletal Tumor Society

Terasaki Institute for Biomedical Innovation announces recipients of inaugural Keith Terasaki Mid-Career Innovation Award

The impact of liver graft preservation method on longitudinal gut microbiome changes following liver transplant

Cardiovascular health risks continue to grow within Black communities, action needed

ALS survival may be cut short by living in disadvantaged communities

No quantum exorcism for Maxwell's demon (but it doesn't need one)

Balancing the pressure: How plant cells protect their vacuoles

Electronic reporting of symptoms by cancer patients can improve quality of life and reduce emergency visits

DNA barcodes and citizen science images map spread of biocontrol agent for control of major invasive shrub

Pregnancy complications linked to cardiovascular disease in the family

Pancreatic cancer immune map provides clues for precision treatment targeting

How neighborhood perception affects housing rents: A novel analytical approach

Many adults report inaccurate beliefs about risks and benefits of home firearm access

Air pollution impacts an aging society

UC Davis researchers achieve total synthesis of ibogaine

Building better biomaterials for cancer treatments

Brain stimulation did not improve impaired motor skills after stroke

Some species of baleen whales avoid attracting killer whales by singing too low to be heard

Wasteful tests before surgery: Study shows how to reduce them safely

UCalgary researchers confirm best approach for stroke in medium-sized blood vessels

Nationwide, 34 local schools win NFL PLAY 60 grants to help students move more

New software developed at Wayne State University will help study chemical and biological systems

uOttawa study unveils new insights into how neural stem cells are activated in the adult human brain

Cystic fibrosis damages the immune system early on

[Press-News.org] Lundquist investigator Chang's study in JAMA Internal Medicine
For critically ill patients with advanced medical illnesses and poor prognoses, overuse of invasive ICU treatment may prolong suffering