PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Lundquist investigator Chang's study in JAMA Internal Medicine

For critically ill patients with advanced medical illnesses and poor prognoses, overuse of invasive ICU treatment may prolong suffering

Lundquist investigator Chang's study in JAMA Internal Medicine
2021-04-14
(Press-News.org) LOS ANGELES (April 13, 2021) -- The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues' study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - "Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments" - found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings. This intervention was associated with reductions in invasive ICU treatments that prolonged suffering without benefit for patients and their families.

"Invasive ICU treatments are frequently delivered to patients who have very little chance of benefit. This leads to prolonged suffering for our patients and their families. We believed that poor communication was one of the key causes for this problem. In our study, we found that training physicians to use time-limited trials of ICU treatments engages families to make decisions together with the physicians and reduces unnecessary ICU treatments." said Dr. Chang.

The published study can be assessed here.

INFORMATION:

JAMA doi: 10.1001/jamainternmed.2021.1000

Media Contact for The Lundquist Institute: Max Benavidez max.benavidez@lundquist.org 310-200-2682

About The Lundquist Institute: Research with reach The Lundquist Institute is an engine of innovation with a global reach and a 69-year reputation of improving and saving lives. With its new medical research building, its state-of-the-art incubator, "BioLabs at The Lundquist," existing laboratory and support infrastructure, and the development of a new 15-acre business tech park, The Lundquist Institute serves as a hub for the Los Angeles area's burgeoning biotech scene. The research institute has over 100 principal investigators (PhDs, MDs, and MD/PhDs) working on more than 600 research studies, including therapies for numerous, and often fatal orphan diseases.


[Attachments] See images for this press release:
Lundquist investigator Chang's study in JAMA Internal Medicine

ELSE PRESS RELEASES FROM THIS DATE:

Telescopes unite in unprecedented observations of famous black hole

2021-04-14
In April 2019, scientists released the first image of a black hole in galaxy M87 using the Event Horizon Telescope (EHT). However, that remarkable achievement was just the beginning of the science story to be told. Data from 19 observatories released today promise to give unparalleled insight into this black hole and the system it powers, and to improve tests of Einstein's General Theory of Relativity. "We knew that the first direct image of a black hole would be groundbreaking," says Kazuhiro Hada of the National Astronomical Observatory of Japan, a co-author of a new study published in The Astrophysical Journal Letters that ...

Climate change is making Indian monsoon seasons more chaotic

2021-04-14
If global warming continues unchecked, summer monsoon rainfall in India will become stronger and more erratic. This is the central finding of an analysis by a team of German researchers that compared more than 30 state-of-the-art climate models from all around the world. The study predicts more extremely wet years in the future - with potentially grave consequences for more than one billion people's well-being, economy, food systems and agriculture. "We have found robust evidence for an exponential dependence: For every degree Celsius of warming, monsoon rainfalls will likely increase by about 5%," says lead author Anja Katzenberger from the Potsdam-Institute ...

Ancient pottery reveals the first evidence for honey hunting in prehistoric West Africa

Ancient pottery reveals the first evidence for honey hunting in prehistoric West Africa
2021-04-14
A team of scientists, led by the University of Bristol, with colleagues from Goethe University, Frankfurt, has found the first evidence for ancient honey hunting, locked inside pottery fragments from prehistoric West Africa, dating back some 3,500 years ago. Honeybees are an iconic species, being the world's most important pollinator of food crops. Honeybee hive products, including beeswax, honey and pollen, used both for food and medicinal purposes, support livelihoods and provide sources of income for local communities across much of Africa, through both beekeeping ...

Toxic gas in rat brains shows potential for new dementia treatments

2021-04-14
A potential treatment for dementia and epilepsy could look to reduce the amounts of a toxic gas in the brain has been revealed in a new study using rat brain cells. The research published in Scientific Reports today [Wednesday 14 April] shows that treatments to reduce levels of hydrogen sulfide (H2S) in the brain may help to ward off damage caused by the gas. By testing rat brain cells, the team of scientists from the University of Reading, University of Leeds and John Hopkins University in the USA found that H2S is involved in blocking a key brain cell gateway ...

Indigenous land-use reduced catastrophic wildfires on the Fish Lake Plateau

Indigenous land-use reduced catastrophic wildfires on the Fish Lake Plateau
2021-04-14
If you were to visit the Great Basin and Colorado Plateau a thousand years ago, you'd find conditions remarkably familiar to the present. The climate was warm, but drier than today. There were large populations of Indigenous people known as the Fremont, a who hunted and grew crops in the area. With similar climate and moderate human activity, you might expect to see the types of wildfires that are now common to the American West: infrequent, gigantic and devastating. But you'd be wrong. In a new study led by the University of Utah, researchers found that ...

Is it possible to predict when a woman will enter menopause?

2021-04-14
CLEVELAND, Ohio (April 14, 2021)--Despite all the advances in medicine, some basic questions remain. For example, people cannot be told with any certainty how long they'll live. Nor can it be predicted exactly when a woman's childbearing years will end. However, a new study offers insights into factors that might predict a woman's age at natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). Factors that affect age at natural menopause are one of the most frequently studied topics in menopause-related research in recent decades, and with good reason. Knowing when a woman will enter menopause could be ...

Superbug killer: New nanotech destroys bacteria and fungal cells

Superbug killer: New nanotech destroys bacteria and fungal cells
2021-04-14
Researchers have developed a new superbug-destroying coating that could be used on wound dressings and implants to prevent and treat potentially deadly bacterial and fungal infections. The material is one of the thinnest antimicrobial coatings developed to date and is effective against a broad range of drug-resistant bacteria and fungal cells, while leaving human cells unharmed. Antibiotic resistance is a major global health threat, causing at least 700,000 deaths a year. Without the development of new antibacterial therapies, the death toll could rise to 10 million people a year by 2050, equating to $US100 trillion in health care costs. While the health burden of fungal infections is less recognised, globally they kill about ...

How nonprofits can drive more giving from their current donor base

2021-04-14
Researchers from University of Hawaii and Cornell University published a new paper in the Journal of Marketing that explores the challenges and opportunities with nonprofit fundraising to provide organizations with strategies they can use to increase sustainable giving and profitability. The study, forthcoming in the Journal of Marketing, is titled "Managing Members, Donors, and Member-Donors for Effective Non-profit Fundraising" and is authored by Sungjin Kim, Sachin Gupta, and Clarence Lee. Individual philanthropy is the primary funding source for many nonprofit organizations. A major challenge facing such organizations ...

Rapid decreases in resting heart rate from childhood to adulthood may indicate heart trouble ahead

Rapid decreases in resting heart rate from childhood to adulthood may indicate heart trouble ahead
2021-04-14
While a slow resting heart rate is generally considered a good thing, investigators have some of the first evidence that if that rate decreases rapidly as children move into young adulthood, it's an indicator that cardiovascular disease may be in their future. Medical College of Georgia investigators report a significant association between a faster decrease in resting heart rate from childhood to adulthood and a larger left ventricle, the heart's major pumping chamber, over a 21-year period in hundreds of individuals who were healthy at the start. The faster decrease in heart rate also was associated with a higher level of pressure inside the blood vessels of the body, which ...

Power of light and oxygen clears Alzheimer's disease protein in live mice

2021-04-14
A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids. Researchers injected the molecule directly into the brains of live mice with Alzheimer's disease and then used a specialized probe to shine light into their brains for 30 minutes each day for one week. Chemical analysis of the mouse brain tissue showed that the treatment significantly reduced amyloid protein. Results from additional ...

LAST 30 PRESS RELEASES:

Making lighter work of calculating fluid and heat flow

Normalizing blood sugar can halve heart attack risk

Lowering blood sugar cuts heart attack risk in people with prediabetes

Study links genetic variants to risk of blinding eye disease in premature infants

Non-opioid ‘pain sponge’ therapy halts cartilage degeneration and relieves chronic pain

AI can pick up cultural values by mimicking how kids learn

China’s ecological redlines offer fast track to 30 x 30 global conservation goal

Invisible indoor threats: emerging household contaminants and their growing risks to human health

Adding antibody treatment to chemo boosts outcomes for children with rare cancer

Germline pathogenic variants among women without a history of breast cancer

Tanning beds triple melanoma risk, potentially causing broad DNA damage

Unique bond identified as key to viral infection speed

Indoor tanning makes youthful skin much older on a genetic level

Mouse model sheds new light on the causes and potential solutions to human GI problems linked to muscular dystrophy

The Journal of Nuclear Medicine ahead-of-print tip sheet: December 12, 2025

Smarter tools for peering into the microscopic world

Applications open for funding to conduct research in the Kinsey Institute archives

Global measure underestimates the severity of food insecurity

Child survivors of critical illness are missing out on timely follow up care

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

University of Toronto launches Electric Vehicle Innovation Ontario to accelerate advanced EV technologies and build Canada’s innovation advantage

Early relapse predicts poor outcomes in aggressive blood cancer

American College of Lifestyle Medicine applauds two CMS models aligned with lifestyle medicine practice and reimbursement

Clinical trial finds cannabis use not a barrier to quitting nicotine vaping

Supplemental nutrition assistance program policies and food insecurity

Switching immune cells to “night mode” could limit damage after a heart attack, study suggests

URI-based Global RIghts Project report spotlights continued troubling trends in worldwide inhumane treatment

Neutrophils are less aggressive at night, explaining why nighttime heart attacks cause less damage than daytime events

Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations

Mobile health tool may improve quality of life for adolescent and young adult breast cancer survivors

[Press-News.org] Lundquist investigator Chang's study in JAMA Internal Medicine
For critically ill patients with advanced medical illnesses and poor prognoses, overuse of invasive ICU treatment may prolong suffering