Racial/ethnic disparities in ophthalmology clinical trials of FDA-approved drugs

BOSTON -- The foods people buy at a workplace cafeteria may not always be chosen to satisfy an individual craving or taste for a particular food. When co-workers are eating together, individuals are more likely to select foods that are as healthy--or unhealthy--as the food selections on their fellow employees' trays. "We found that individuals tend to mirror the food choices of others in their social circles, which may explain one way obesity spreads through social networks," says Douglas Levy, PhD, an investigator at the Mongan Institute Health Policy Research Center at Massachusetts General Hospital (MGH) ...

A phase 1 clinical trial led by investigators at the University of Chicago Medicine testing the effects of stereotactic body radiotherapy for treating multiple metastases has determined that treatments used for single tumors can also be safely used for treating patients with multiple metastases. The study was run through NRG Oncology and sponsored by the National Cancer Institute. The results were published on April 22 in JAMA Oncology. Cancer is traditionally treated with a combined approach, with clinicians using surgery, chemotherapy and radiation therapy to kill and remove cancerous tumors. Systemic ...

PHILADELPHIA--When researchers from Penn Medicine found that many patients with B-cell acute lymphoblastic leukemia (ALL) treated with the investigational chimeric antigen receptor (CAR) T cell therapy targeting the CD22 antigen didn't respond, they went back to the drawing board to determine why. They discovered that less is more when it comes to the length of what is known as the single-chain variable fragment -- the linker that bridges the two halves of the receptor that allows CAR T cells to latch onto tumor cells and attack them. The findings are reported online today in Nature Medicine. "A little difference of a few amino acids can make a huge difference for patients," said co-senior author Marco Ruella, MD, an ...

The 'stickiness', or viscosity, of microscopic liquids can now be measured thousands of times faster than ever before, potentially leading to better understanding of living cells, disease diagnostics and pharmaceutical testing. University of Queensland's Professor Warwick Bowen and his colleagues at the Queensland Quantum Optics Lab developed the world-leading technology, technology that uses lasers to track microscale particles with world-record precision. "The stickiness, or viscosity, of liquids is incredibly important in biology," Professor Bowen said. "In living cells, viscosity fluctuations control shape and structure, modulate chemical reactions, and signal whether a cell is healthy or cancerous. "However, ...

A new study has highlighted that while much is known about the ever increasing uptake of antidepressant medications around the world, there is very little evidence on safe and effective approaches to discontinuing treatment. In 2020 there were 78 million prescriptions for antidepressants in England and about half of patients treated have taken them for at least two years. Guidelines typically recommend that antidepressants be taken for up to 6 to 12 months after improvement, or for up to two years in people at risk of relapse, but many people take antidepressants for much longer. Surveys of antidepressant users suggest that up to a half of people on long-term antidepressant prescriptions have no clear medical ...

Skeletal muscles enable voluntary movements and are controlled by a special type of neurons called motor neurons, which make direct contact with skeletal muscles through so-called neuromuscular junctions (NMJs). It is through NMJs that skeletal muscles receive signals making them contract or relax. In certain neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), NMJs are destroyed, leading to progressive muscle weakness and ultimately death. Treatments for ALS mainly focus on alleviating symptoms but cannot stop or reverse its disease progression. To find more effective treatments, researchers require accurate and easily accessible lab-based models for ALS to understand its causes and to develop and test new therapies. One step in this ...

Transient grating spectroscopy is an elegant method that uses two laser pulses to activate a medium by creating an interference pattern made of parallel stripes of excitations that can be thermal, electronic, magnetic or even structural. The modulation depth of the pattern and its evolution can be measured by diffracting a third, time-delayed probe beam on the transient grating. The modulation depth decays as the initial excitation propagates through the material. The distance between the stripes is determined by the wavelength of the pulses used to create the grating, which ...

Researchers at the Paul Scherrer Institute PSI have succeeded for the first time in looking inside materials using the method of transient grating spectroscopy with ultrafast X-rays at SwissFEL. The experiment at PSI is a milestone in observing processes in the world of atoms. The researchers are publishing their research results today in the journal Nature Photonics. The structures on microchips are becoming ever tinier; hard disks write entire encyclopedias on magnetic disks the size of a fingernail. Many technologies are currently breaking through the boundaries of ...

States with stricter firearms laws reported lower suicide and homicide rates, according to a Rutgers study. The study, conducted by the New Jersey Gun Violence Research Center, the Rutgers School of Public Health, the Rutgers University-Newark Department of Psychology, the Rutgers School of Criminal Justice, the Rutgers New Jersey Medical School and the Rutgers-Newark Department of Social Work, was published in the Journal of Public Health and examined the association between firearm laws and suicide and homicide rates. Firearm violence is a major public health concern in the United States, with firearm suicide ...

Irvine, Calif., April 22, 2021 -- California's wildfire problem, fueled by a concurrence of climate change and a heightened risk of human-caused ignitions in once uninhabited areas, has been getting worse with each passing year of the 21st century. Researchers in the Department of Civil & Environmental Engineering at the University of California, Irvine have conducted a thorough analysis of California Department of Forestry and Fire Protection wildfire statistics from 2000 to 2019, comparing them with data from 1920 to 1999. They learned that the annual burn season has lengthened in the past two decades and that the yearly peak has shifted from August to July. The team's findings are the subject of a study published today in the ...