Socioeconomic disadvantage, long-term outcomes after heart attack

What The Study Did: This study looked at the use of consumer digital information for COVID-19 control U.S. adults consider to be acceptable and the factors associated with higher or lower approval of using this information. Authors: David Grande, M.D., M.P.A., of the University of Pennsylvania, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10918) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. #  #  # Media advisory: ...

What The Study Did: SARS-CoV-2 seropositivity wasn't associated with low levels of vitamin D independently of other risk factors. Authors: Yonghong Li, Ph.D., of Quest Diagnostics in San Juan Capistrano, California, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.11634) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, ...

What The Study Did: Clinical characteristics and outcomes of patients with multisystem inflammatory syndrome among adults with laboratory-confirmed SARS-CoV-2 infection at a single U.S. medical center are described in this study. Authors: Giovanni E. Davogustto, M.D., of the Vanderbilt University Medical Center in Nashville, Tennessee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10323) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: Racial and ethnic representation among departmental chairs and faculty in academic medicine in the United States from 1980 to 2019 was examined in this study. Authors: Darrion Mitchell, M.D., Ph.D., of the Ohio State University James Cancer Center in Columbus, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.10726) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and ...

Philadelphia, May 19, 2021 - A multidisciplinary team of researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn) showed how the "batteries" of cells are highly implicated in whether patients with the chromosome 22q11.2 deletion syndrome develop schizophrenia. The results of the study may eventually lead to targeted prevention and treatment strategies for patients with the condition. The findings were published today in JAMA Psychiatry. 22q11.2 deletion syndrome (22q) is ...

The common skin disease atopic eczema (AE) impacts heavily on the life quality and general health of sufferers. Researchers at Karolinska Institutet in Sweden have now evaluated its treatment with internet-delivered cognitive behavioural therapy (iCBT). The study suggests that patients feel better after iCBT compared with a control group who received only traditional treatment. The results, which are published in JAMA Dermatology, might eventually make important care available to a large patient group. "We've carried out a promising pilot study but were still surprised at how effective internet-delivered CBT ...

A pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the production of tau; a protein which plays a critical role in serious degenerative conditions, such as Parkinson's and Alzheimer's disease. The international research, conducted in mice and cells, also revealed this material is part of a larger family of non-coding genes* which control and regulate other similar brain proteins, such as beta-amyloid associated with Alzheimer's and alpha-synuclein implicated in Parkinson's disease and Lewy body dementia. Researchers say the breakthrough findings, ...

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team led by the University of Zurich has succeeded in sustainably lowering high LDL cholesterol levels in the blood of mice and macaques. This opens up the possibility of curing patients with inherited metabolic liver diseases. Lipoproteins are complex particles that deliver fat molecules to all tissues of the body through the blood system, supplying energy to the cells. One such lipoprotein, the low-density lipoprotein (LDL), can transport thousands of fat molecules, such as cholesterol, per particle. High levels of LDL in the blood are clinically associated with an ...

Wednesday 19 May 2021 - New research published today sheds important light on how the production of a key protein in the brain is controlled, which could pave the way for new treatments for a wide range of neurological conditions. In a study part-funded by Parkinson's UK, researchers investigated a section of genetic material known as antisense long non-coding RNA (lncRNA), which helps fine-tune the production of the protein tau inside brain cells. This precision in tau regulation is crucial for smooth functioning of the nerve cells. Understanding the mechanism ...

Unbound nickel atoms and other heavy elements have been observed in very hot cosmic environments, including the atmospheres of ultra-hot exoplanets and evaporating comets that ventured too close to our Sun or other stars. A new study conducted by JU researchers reveals the presence of nickel atoms in the cold gasses surrounding the interstellar comet 2I/Borisov. The team's finding is being published in Nature on 19 May 2021. Interstellar comets and asteroids are precious to science because, unlike millions of minor bodies that formed in our Solar System, they originate from distant planetary systems. Until very recently, the existence of such cosmic vagabonds has merely ...