(Press-News.org) In the quest for healthy aging and longer lifespan, Danish researchers at the University of Southern Denmark have collaborated with Swedish researchers at Karolinska Institutet to explore the anti-aging effects of football and team handball training in women.
In a current study published in Scientific Reports, the researchers investigated the effects of lifelong regular exercise on two of the central hallmarks of aging combined and showed that football and team handball have a positive effect on telomere length and mitochondrial function in women.
"Our legacy consists of DNA that is packed in chromosomes. When cells divide, the inheritance is copied, but with each cell division the ends of the DNA threads get shorter. The so-called telomeres are shortened, which causes us to age. It is remarkable that engaging in team sports such as football and handball helps women to maintain longer telomeres and healthy mitochondria. It may potentially increase their health span and, ultimately, lifespan, as shorter telomeres and mitochondrial dysfunction are both associated with a number of age-related diseases and mortality," says senior researcher Muhammad Asghar, the study's shared senior author, of the Department of Medicine, Solna at Karolinska Institutet.
Younger biological age in the cells as evaluated by telomere length
"We've recently shown that 65-80-year-old male football players are in excellent physical shape in comparison to untrained age-matched individuals, evidenced by markedly higher aerobic fitness, muscle mass and bone strength as well as a younger biological age in the cells as evaluated by telomere length," says Professor Peter Krustrup, the study's shared senior author, of the Department of Sports Science and Clinical Biomechanics at the University of Southern Denmark, and adds:
"Interestingly, the present study shows the same pattern, including a positive effect on mitochondrial health, in 60-80-year-old female team handball players, thereby supporting the evidence for an anti-aging potential of team sports."
"In addition to the positive findings in elderly team handball players, we observed that young female elite football players have ~23% longer telomeres in specific blood cells compared to untrained age-matched women," says PhD Marie Hagman, the study's first author, of the Department of Sports Science and Clinical Biomechanics at the University of Southern Denmark.
"These results are striking because differences in telomere length of that magnitude are not normally found in young participants. It should be noted, however, that this is a cross-sectional study and that our findings need to be confirmed by future randomised controlled trials," Hagman explains.
The study involved 129 healthy, non-smoking women, including young elite football players (YF, n=29, 18-30 yrs), young untrained controls (YC, n=30, 18-30 yrs), elderly team handball players (EH, n=35, 60-80 yrs) and elderly untrained controls (EC, n=35, 60-80 yrs). The study was the first to investigate the effects of lifelong regular exercise in humans on two of the central aging hallmarks combined.
Elite football and lifelong team handball training are associated with beneficial anti-aging cellular effects
The results of the study showed that elite football and lifelong team handball training are associated with beneficial anti-aging cellular effects in women. Specifically, young elite football players demonstrated higher telomere length and higher mtDNA copy number compared to young untrained controls, while elderly team handball players showed healthy mitochondria compared to elderly untrained controls. These cellular adaptations were also positively correlated with VO2max and the amount of weekly exercise, emphasizing the importance for these women, irrespective of age, to maintain a reasonable fitness and activity level.
The research was led by Peter Krustrup, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, and Muhammad Asghar, Department of Medicine, Solna, Karolinska Institutet. The work was carried out with support from the Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster, University of Southern Denmark, Denmark, and the Novo Nordisk Foundation grant to Team Denmark granted to Peter Krustrup, as well as grants to Muhammad Asghar from the Swedish Research Council and Ragnar Söderberg Foundation.
Marie Hagman, Bjørn Fristrup, Rémi Michelin, Peter Krustrup, Muhammad Asghar. Football and team handball training postpone cellular aging in women. Scientific Reports - Nature.
Marie Hagman, Christian Werner, Katharina Kamp, Bjørn Fristrup, Therese Hornstrup, Tim Meyer, Michael Böhm, Ulrich Laufs, Peter Krustrup (2020). Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls. Progress in Cardiovascular Diseases 63(6):738-749.
High blood pressure, or hypertension, is the leading modifiable risk factor for cardiovascular diseases and premature death worldwide. And key to treating patients with conditions ranging from chest pain to stroke is understanding the intricacies of how the cells around arteries and other blood vessels work to control blood pressure. While the importance of metals like potassium and calcium in this process are known, a new discovery about a critical and underappreciated role of another metal - zinc - offers a potential new pathway for therapies to treat hypertension.
The study results were published recently in Nature Communications.
All the body's functions depend on arteries channeling oxygen-rich ...
The COVID-19 pandemic continues to disrupt and end lives around the world, and public health officials worldwide have recognized vaccines as the critical tools required for controlling the COVID-19 death toll and achieving a return to normal life. Several vaccines against COVID-19 are already in use, but the limited supplies of these vaccines and the possibility of safety and efficacy issues of the existing vaccines mean that it is important for scientists to develop more (and even better) vaccines. In fact, as of February 2021, 69 different vaccines are in various phases of clinical development.
One type of vaccine that could prove quite useful is the inactivated vaccine, which contains an inactivated form of the virus. The inactivated virus cannot harm the recipient, but ...
A new study published in the journal Diversity and Distributions predicts massive range declines of Africa's great apes - gorillas, chimpanzees and bonobos - due to the impacts of climate change, land-use changes and human population growth.
For their analysis, the authors compiled information on African ape occurrence held in the IUCN SSC A.P.E.S. database, a repository that includes a remarkable amount of information on population status, threats and conservation for several hundred sites, collected over 20 years.
The first-of-its-kind study quantifies the joint effects of climate, land-use, and human population changes across African ape ranges for the year ...
Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions.
Six HCC cell lines were cultured in "standard" or more "native" conditions.
HCC cells cultured in native conditions had slower doubling times, increased HK2 and GLUT, lower PHDA and ATP levels, and mutations in mitochondrial DNA.
From 90 comparisons of drug sensitivity, increased resistance ...
Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.
Using quantitative multiplex immunohistochemistry, the authors analyzed skin squamous-cell carcinoma (sSCC) sections from 36 patients.
CD8 T cell infiltration showed great differences between patients, whereby these ...
ADELPHI, Md. -- Army researchers developed a pioneering framework that provides a baseline for the development of collaborative multi-agent systems.
The framework is detailed in the survey paper Survey of recent multi-agent reinforcement learning algorithms utilizing centralized training, which is featured in the SPIE Digital Library. Researchers said the work will support research in reinforcement learning approaches for developing collaborative multi-agent systems such as teams of robots that could work side-by-side with future Soldiers.
"We propose that the underlying information sharing mechanism plays a critical role in centralized learning for multi-agent systems, ...
WASHINGTON -- For more than 25 years, Burmese pythons have been living and breeding in the Florida Everglades where they prey on native wildlife and disrupt the region's delicate ecosystems. A new study shows that infrared cameras could make it easier to spot these invasive snakes in the Florida foliage, providing a new tool in the effort to remove them.
In the Optical Society (OSA) journal Applied Optics, researchers led by Dr. Kyle Renshaw from the University of Central Florida College of Optics and Photonics report that a near infrared camera helped people detect Burmese pythons at distances up to 1.3 times farther away than was possible using a traditional visible-wavelength ...
AMES, Iowa - Scientists have invested great time and effort into making connections between a plant's genotype, or its genetic makeup, and its phenotype, or the plant's observable traits. Understanding a plant's genome helps plant biologists predict how that plant will perform in the real world, which can be useful for breeding crop varieties that will produce high yields or resist stress.
But environmental conditions play a role as well. Plants with the same genotype will perform differently when grown in different environments. A new study led by an Iowa State University scientist uses advanced data analytics to help scientists understand ...
A study conducted by a group of Brazilian researchers contributes to a deeper understanding of the molecular basis for schizophrenia, and potentially to the development of more specific and effective treatments for the disease. The medications currently available on the market act generically on the brain and can have severe adverse side effects.
Treatment of post-mortem samples from the hippocampus of schizophrenic patients with an NMDA receptor antagonist pointed to biological processes associated with the disease that are specific to neurons and oligodendrocytes. NMDA receptors are neurotransmitter receptors located in the postsynaptic ...
In those with fatty liver disease, a person's fat goes to their liver instead of their fat tissue, either because of an absence of fat depots, which is seen in the rare genetic disease lipodystrophy, or because the depots are too full, which is seen in people with obesity.
One third of these people will go on to develop nonalcoholic steatohepatitis, or NASH - an advanced form of fatty liver disease brought on by progressive inflammation and scarring in the organ.
In 2002, Michigan Medicine endocrinologist Elif Oral, M.D., who had just moved from the National Institutes of Health at the time, published her discovery that patients with severe lipodystrophy lack leptin, a hormone that helps curb appetite and control weight gain. When given ...