PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Researchers use AI to track cognitive deviation in aging brains

Researchers use AI to track cognitive deviation in aging brains
2021-06-23
(Press-News.org) OAK BROOK, Ill. - Researchers have developed an artificial intelligence (AI)-based brain age prediction model to quantify deviations from a healthy brain-aging trajectory in patients with mild cognitive impairment, according to a study published in Radiology: Artificial Intelligence. The model has the potential to aid in early detection of cognitive impairment at an individual level.

Amnestic mild cognitive impairment (aMCI) is a transition phase from normal aging to Alzheimer's disease (AD). People with aMCI have memory deficits that are more serious than normal for their age and education, but not severe enough to affect daily function.

For the study, Ni Shu, Ph.D., from State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, in Beijing, China, and colleagues used a machine learning approach to train a brain age prediction model based on the T1-weighted MR images of 974 healthy adults aged from 49.3 to 95.4 years. The trained model was applied to estimate the predicted age difference (predicted age vs. actual age) of aMCI patients in the Beijing Aging Brain Rejuvenation Initiative (616 healthy controls and 80 aMCI patients) and the Alzheimer's Disease Neuroimaging Initiative (589 healthy controls and 144 aMCI patients) datasets.

The researchers also examined the associations between the predicted age difference and cognitive impairment, genetic risk factors, pathological biomarkers of AD, and clinical progression in aMCI patients.

The results showed that aMCI patients had brain-aging trajectories distinct from the typical normal aging trajectory, and the proposed brain age prediction model could quantify individual deviations from the typical normal aging trajectory in these patients. The predicted age difference was significantly associated with individual cognitive impairment of aMCI patients in several domains, specifically including memory, attention and executive function.

"The predictive model we generated was highly accurate at estimating chronological age in healthy participants based on only the appearance of MRI scans," the researchers wrote. "In contrast, for aMCI, the model estimated brain age to be greater than 2.7 years older on average than the patient's chronological age."

The model further showed that progressive aMCI patients exhibit more deviations from typical normal aging than stable aMCI patients, and the use of the predicted age difference score along with other AD-specific biomarkers could better predict the progression of aMCI. Apolipoprotein E (APOE) ε4 carriers showed larger predicted age differences than non-carriers, and amyloid-positive patients showed larger predicted age differences than amyloid-negative patients.

Combining the predicted age difference with other biomarkers of AD showed the best performance in differentiating progressive aMCI from stable aMCI.

"This work indicates that predicted age difference has the potential to be a robust, reliable and computerized biomarker for early diagnosis of cognitive impairment and monitoring response to treatment," the authors concluded.

INFORMATION:

"Accelerated Brain Aging in Amnestic Mild Cognitive Impairment: Relationships with Individual Cognitive Decline, Risk Factors for Alzheimer Disease and Clinical Progression." Weijie Huang, Xin Li, He Li, Wenxiao Wang, Kewei Chen, Kai Xu, Junying Zhang, Yaojing Chen, Dongfeng Wei, Ni Shu, Ph.D., and Zhanjun Zhang.

Radiology: Artificial Intelligence is edited by Charles E. Kahn Jr., M.D., M.S., Perelman School of Medicine at the University of Pennsylvania, and owned and published by the Radiological Society of North America, Inc. (https://pubs.rsna.org/journal/ai)

RSNA is an association of radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Illinois. (RSNA.org)

For information on brain MRI and Alzheimer's Disease, visit RadiologyInfo.org.


[Attachments] See images for this press release:
Researchers use AI to track cognitive deviation in aging brains

ELSE PRESS RELEASES FROM THIS DATE:

Toxic workplaces increase risk of depression by 300%

Toxic workplaces increase risk of depression by 300%
2021-06-23
A year-long Australian population study has found that full time workers employed by organisations that fail to prioritise their employees' mental health have a threefold increased risk of being diagnosed with depression. And while working long hours is a risk factor for dying from cardiovascular disease or having a stroke, poor management practices pose a greater risk for depression, the researchers found. The University of South Australia study, published in the British Medical Journal today, is led by UniSA's Psychosocial Safety Climate Observatory, the world's first research platform exploring workplace psychological health and safety. Psychosocial safety climate (PSC) is the term used to describe management practices ...

How to make lithium-ion batteries invincible

How to make lithium-ion batteries invincible
2021-06-23
In our future electrified world, the demand for battery storage is projected to be enormous, reaching to upwards of 2 to 10 terawatt-hours (TWh) of annual battery production by 2030, from less than 0.5 TWh today. However, concerns are growing as to whether key raw materials will be adequate to meet this future demand. The lithium-ion battery - the dominant technology for the foreseeable future - has a component made of cobalt and nickel, and those two metals face severe supply constraints on the global market. Now, after several years of research led by Lawrence Berkeley National Laboratory (Berkeley Lab), scientists have made significant progress in developing battery cathodes using ...

AI spots healthy stem cells quickly and accurately

AI spots healthy stem cells quickly and accurately
2021-06-23
Tokyo, Japan - Stem cell therapy is at the cutting edge of regenerative medicine, but until now researchers and clinicians have had to painstakingly evaluate stem cell quality by looking at each cell individually under a microscope. Now, researchers from Japan have found a way to speed up this process, using the power of artificial intelligence (AI). In a study published in February in Stem Cells, researchers from Tokyo Medical and Dental University (TMDU) reported that their AI system, called DeepACT, can identify healthy, productive skin stem cells with the same accuracy that a human can. Stem cells are able to develop into several different kinds of mature ...

Bioinspired mineralization of calcium carbonate in peptide hydrogel

Bioinspired mineralization of calcium carbonate in peptide hydrogel
2021-06-23
A team of researchers developed a biomimetic mineralization of calcium carbonate using a multifunctional peptide template that can self-supply mineral sources, which in this case is a supply of carbonate ions, the precursor of calcium carbonate, and following the mechanism of biosynthesis of hard tissues by living organisms, called biomineralization, the ability to form hydrogels, which is modeled after the reaction environment of living organisms. Previous studies on mineralization have discussed the formation mechanism of inorganic crystals synthesized on ...

Rapid progression in cardiovascular disease risk factors can reveal high-risk individuals

2021-06-23
Current American Heart Association, European Society of Cardiology, and UK National Health Service guidelines recommend a 5-yearly health checks for screening of individuals at high cardiovascular disease risk. These health checks include measurement of major risk factors, such as systolic blood pressure, cholesterol profile, blood glucose, and smoking status. If lifestyle interventions are unsuccessful in reducing risk factor levels, prevention guidelines recommend initiation of preventive medication therapies such as statins. However, current guidelines advice only using the latest ...

If the right hand is hypersensitive due to an injury to the left

2021-06-23
The results of the study were published in the journal "Neurology" on 19 May 2021 under the leadership of Professor Elena Enax-Krumova, holder of the endowed professorship of the German Social Accident Insurance (DGUV). Nerve injuries: frequent complication after occupational accidents Peripheral nerves refer to nerves that lie outside of the brain and spinal cord. They run throughout the entire body. These bundles of nerve fibres can be damaged in the event of blunt or sharp force trauma due to accidents, as well as during surgery. Injuries to the peripheral nerves are a frequent complication, particularly after occupational accidents. Patients often suffer from motor and sensory disorders in the affected area of the body. These can lead to persistent complaints and ...

Junk food relief in lockdown

Junk food relief in lockdown
2021-06-23
Beware of those snack attacks. A new study in Appetite has confirmed the small luxuries, from sweets and chocolate to salty treats, have helped to lift our spirits - and kilojoule intake - during COVID-19 lockdowns. Researchers in England and Australia have gathered evidence about similar experiences in the UK and Victoria, Australia to warn about the effect of extended pandemic lockdowns on our eating behaviours. While time at home provides more time for healthy food preparation, intake of high-energy density foods (HED) has risen for some - presenting at-risk adults with the prospect of managing weight gain, the psychology researchers warn. "The ...

Kit clashes affect performance in football matches, new study shows

2021-06-23
The response times of footballers is slowed down when part of the kit worn by both teams is of the same colour, a new study shows. The research from the University of York revealed that when players have any kit colour clash - either shirt or shorts - it takes them twice as long to find a fellow player on the pitch. Study authors are calling for a change in the laws of the game or for clearer guidance. Researchers used two experiments to investigate how kit variations affect the visual search for teammates. Their first experiment confirmed that a ...

Synthesis of a near-infrared light absorbing macrocyclic aromatic compound

Synthesis of a near-infrared light absorbing macrocyclic aromatic compound
2021-06-23
Profs. Okujima and Uno at Ehime University, in collaboration with Prof. Kobayashi at Shinshu University, reported the selective synthesis, the molecular structure, optical properties and electronic structure of cyclo[9]pyrrole, a ring-expanded porphyrin consisting of directly connected pyrrole rings. Porphyrins, which are well-known natural porphyrin molecules, e.g. heme and chlorophyll, are attractive for use in practical materials because of the easy optimization of their optical and physical properties by conjugation expansion and functionalization. In 2002, Sessler reported the first synthesis of cyclo[n]pyrrole (n: ...

Earth-like biospheres on other planets may be rare

Earth-like biospheres on other planets may be rare
2021-06-23
A new analysis of known exoplanets has revealed that Earth-like conditions on potentially habitable planets may be much rarer than previously thought. The work focuses on the conditions required for oxygen-based photosynthesis to develop on a planet, which would enable complex biospheres of the type found on Earth. The study is published today in Monthly Notices of the Royal Astronomical Society. The number of confirmed planets in our own Milky Way galaxy now numbers into the thousands. However planets that are both Earth-like and in the habitable zone - the region around a star where the temperature is just right for liquid water to exist on the surface - are much less common. At the moment, only a handful of such rocky and potentially habitable exoplanets ...

LAST 30 PRESS RELEASES:

Andrew Siemion to receive the SETI Institute’s 2024 Drake Award

New study shows how the Crimean-Congo hemorrhagic fever virus enters our cells

Neoadjuvant chemotherapy proves effective for locally advanced penile squamous cell carcinoma

Study flips treatment paradigm in bilateral Wilms tumor, shows resistance to chemotherapy may point toward favorable outcomes

Doctors received approximately $12.1 billion from drug and device makers between 2013-2022

Discovery suggests new strategy against follicular lymphoma

Making the future too bright: how wishful thinking can point us in the wrong direction

Ochsner Health named to Newsweek’s America’s Greatest Workplaces 2024 for Job Starters

Three-year study of young stars with NASA’s Hubble enters new chapter

North Carolina takes the lead in PFAs research with Collaboratory’s $3 million investment to expand the state’s research capacity

Is it the school, or the students?

Exploring the relationship between HIV pre-exposure prophylaxis and the incidence of chlamydia, gonorrhea and syphilis – findings from Denmark

Music: Song lyrics have become simpler and more repetitive since 1980

Environment: More than half of Colorado River’s water used to irrigate crops

When inequality is more than “skin-deep”: Social status leaves traces in the epigenome of spotted hyenas in Tanzania

Study explores the future of at-home cancer treatment

First performance standards published to measure the effectiveness of lifestyle medicine treatments

To keep volunteers, connect them

Suppressing boredom at work hurts future productivity, study shows

Older brain cells linger unexpectedly before their death

Clear shift in arterial diseases in diabetes

Celebrating half a century of pioneering excellence: EBMT marks its 50th anniversary

Ancient DNA reveals the appearance of a 6th century Chinese emperor

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

Familial Alzheimer’s disease transferred via bone marrow transplant in mice

Perspectives of oncologists on the ethical implications of using AI for cancer care

Industry payments to US physicians by specialty and product type

Andrew E. Place, MD, PhD appointed as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Vice President, Pediatric Chief Medical Officer

COVID-19 antibody discovery could explain long COVID

Wild plants face viral surprise

[Press-News.org] Researchers use AI to track cognitive deviation in aging brains