PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Snap, crackle, pop: Bone marrow-derived fibrin clot as better source for meniscal repair

Osaka City University shows that bone marrow-derived fibrin clots contain more growth factors than peripheral blood and better fit for meniscal repair surgery

Snap, crackle, pop: Bone marrow-derived fibrin clot as better source for meniscal repair
2021-07-06
(Press-News.org) While this isn't the fountain of youth, scientists may have improved healing in our joints - even in areas that become weaker as we grow older. The meniscus is a durable, yet flexible tissue found in joints like our wrist and knees that helps them absorb shock during movement. Occasionally tears can occur in the meniscus due an awkward movement or structural weakness from old age. When we are young, there is plenty of blood flowing to this area allowing for quick healing, but as we get older, the meniscus receives less and less blood - with the inner most area becoming avascular. Tears in this area do not heal normally, often requiring surgery. Surgeons can draw fibrin, a protein involved in blood clotting, from peripheral blood (PB) or bone marrow aspirate (BMA), and implant a fibrin blood clot into the injured area to help with healing. However, little was known about the differential effectiveness of fibrin from the PB and BMA areas.

Scientists from the Graduate School of Medicine, Osaka City University, have evaluated the clinical results of a meniscal repair using BMA-derived fibrin clots and found that rates of clinical and anatomic failure, and re-tear were 10%, 6.7%, and 3.3% respectively - well below their PB counterpart. The results were published in Arthroscopy: The Journal of Arthroscopic & Related Surgery.

"There are various methods of meniscal repair that try to prevent re-tear" states Lecturer Yusuke Hashimoto, "but the re-tear rate still exceeds 20%". To see if BMA can bring this number down, the research team had to first understand the levels of growth factors involved in tissue repair found in BMA and then see the effects BMA-derived fibrin clots had when sutured into tissue during meniscal surgery.

Collecting bone marrow fluid and peripheral blood from 5 patients undergoing meniscal surgery, the team prepared fibrin clots for cytokine measurement. "Cytokine are proteins that stimulate the reparative process" states Professor Hiroaki Nakamura, "and through them we are able to gauge the levels of growth factors like bFGF, TGFβ, and SDF-1." Cell count evaluations found that BMA was more abundant in these growth factors than PB.

Next, as a 2-year follow-up post-surgery, they examined pre- and post-operative clinical results and the healing rate of meniscus in 30 cases of meniscal surgery that was combined with a BMA fibrin clot. MRI results showed significant improvements in the condition of the meniscus compared to the preoperative results and x-ray evaluation showed no significant progression of knee deformity.

"PB clots have been widely reported as a material to enhance meniscal healing", states Hashimoto. However, with a reported 20% of meniscal repairs having reoperation at long-term follow up, "our method of introducing BMA-derived fibrin clots into the injured area may become a treatment for meniscus injuries that until now have not been curable."

INFORMATION:

We are Osaka City University - the oldest research university in Osaka. With 9 undergraduate faculties and 11 graduate schools all dedicated to making urban life better, energy cleaner, and people healthier and happier, we have won numerous awards and have produced 2 Nobel laureates. For more information, please visit our website at https://www.osaka-cu.ac.jp/en


[Attachments] See images for this press release:
Snap, crackle, pop: Bone marrow-derived fibrin clot as better source for meniscal repair

ELSE PRESS RELEASES FROM THIS DATE:

Modelling COVID-19 cases in Africa

Modelling COVID-19 cases in Africa
2021-07-06
An international team including Lancaster University researchers has created a strategy for understanding the evolution of the COVID-19 pandemic throughout the African continent. Their COVID-19 surveillance strategy will improve the ability of African countries to interpret the complex data available to them during the pandemic. Professor Peter Diggle, Dr Chris Jewell and Dr Claudio Fronterre from the Centre for Health Informatics, Computing and Statistics (CHICAS) at Lancaster Medical School worked with colleagues in the USA, Uganda and Switzerland to create a data-driven disease surveillance framework to track and predict ...

Comprehensive genetic study of cleft lip and palate

Comprehensive genetic study of cleft lip and palate
2021-07-06
Cleft lip and palate is one of the most common congenital malformations. Its causes are mainly genetic. However, it is still largely unknown exactly which genes are affected. A new international study led by the University of Bonn now provides new insights. The results are published in the journal Human Genetics and Genomics Advances, but are already available online. The researchers from the Institute of Human Genetics at the University Hospital Bonn combined various data sources in their work. In the course of their research, they discovered five new regions in the human genome in which variations in the DNA sequence are associated with an ...

New report aims to improve VR use in healthcare education

New report aims to improve VR use in healthcare education
2021-07-06
A new report that could help improve how immersive technologies such as Virtual Reality (VR) and Augmented Reality (AR) are used in healthcare education and training has been published with significant input from the University of Huddersfield. Professor David Peebles, Director of the University's Centre for Cognition and Neuroscience, and Huddersfield PhD graduate Matthew Pears contributed to the report - 'Immersive technologies in healthcare training and education: Three principles for progress' - recently published by the University of Leeds with input from range of academics, technologists and health professionals. The principles have also been expanded upon in a letter to the prestigious journal BMJ ...

Ultra-strong squeezing of light demonstrated for ultrafast optical signal processing

Ultra-strong squeezing of light demonstrated for ultrafast optical signal processing
2021-07-06
A train carrying cargo has finite space. The amount of cargo that can be carried onboard is limited by the size of the cargo and the capacity of the train. Analogously, the amount of time taken up by an optical signal limits the amount of data that can be carried. Temporally shorter signals allow more data to be squeezed into a given time duration, in a method called optical time division multiplexing. Photonics researchers have recently succeeded in squeezing light in time by 11 times. The developed temporal compression system allows an equivalent increase in the number of bits transmitted by light ...

Study shows laboratory developed protein spikes consistent with COVID-19 virus

Study shows laboratory developed protein spikes consistent with COVID-19 virus
2021-07-06
A new international study has found that the key properties of the spikes of SARS-CoV-2 virus which causes COVID-19 are consistent with those of several laboratory-developed protein spikes, designed to mimic the infectious virus. A central component in designing serological tests and vaccines to protect against COVID-19 is the manufacture of protein "spikes". These recombinant spikes closely mimic those sticking out of surface of the infectious virus and trigger the body's immune system into action. Laboratory manufactured spikes are also used for serological testing (also referred to as antibody testing) and as research reagents. The findings show how that viral spike manufactured through different methods in laboratories across the globe ...

Remdesivir in COVID-19: Indication of considerable added benefit for a part of the patients

2021-07-06
Since July 2020, remdesivir has been conditionally approved in Europe for the treatment of coronavirus disease (COVID-19) in adults and adolescents aged 12 years and older with pneumonia who require supplemental oxygen but no invasive ventilation. In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated whether the drug, which was originally developed for the treatment of Ebola virus disease, offers these patients an added benefit compared to the appropriate comparator therapy (here: therapy according to physician's choice). This investigation yielded an indication of a considerable added benefit of remdesivir compared to the appropriate comparator therapy for adults with pneumonia ...

Researchers shed light on memory effects in multi-step evolution of open quantum system

2021-07-06
In a study published in Physical Review Letters, academician GUO Guangcan's team from University of Science and Technology of China of the Chinese Academy of Sciences made progress in the open quantum system research. This team, collaborating with Austrian theoretical physicist Philip Taranto, demonstrated the non-Markovianity in the multi-step evolution of the open quantum system, and proved the measurement-dependent property of quantum memory effects. In quantum information science, it is crucial to understand and control the memory effects for the development of quantum technology. For the coupling of the system and environment, the evolution of open quantum system presents the non-Markovianity, ...

Potential of faba beans, rich in protein, has been unlocked

Potential of faba beans, rich in protein, has been unlocked
2021-07-06
Faba beans have been an excellent source of food protein since pre-historic times, but about 5% of people, mostly from regions where malaria has been endemic and who carry a certain mutation, can't eat them. Now, an international team of researchers, led by the Universities of Helsinki and Copenhagen as well as Luke Natural Resources Institute Finland, has identified the gene responsible for the production of vicine and convicine, which are harmful to these people. In the work published in Nature Plants, the team reports that the VC1 gene plays a central role in the biosynthesis these compounds. Faba beans - Pythagoras and his followers avoided them and Roman priests of Jupiter associated them with death. ...

Researchers discover unusual competition between charge density wave and superconductivity

2021-07-06
A research team led by Prof. CHEN Xianhui from University of Science and Technology of China of the Chinese Academy of Sciences (CAS) found an unusual competition between charge density wave (CDW) and superconductivity in CsV3Sb5, a layered kagome metal, which provides key experimental evidence for understanding novel CDW and superconductivity. The result was published on Nature Communications and recommended as featured article. Traditional superconductivity and CDW are two different electronic states, which both originate from electron phonon coupling and Fermi instability. In the conventional coexistence image of CDW and superconductor, after entering the CDW state, the energy gap is opened due to the nesting of Fermi surface, resulting in the loss of density ...

Gulf Coast ready to develop carbon storage hub

Gulf Coast ready to develop carbon storage hub
2021-07-06
The stage is set for a new carbon storage economy to emerge along the Gulf Coast, according to a study led by The University of Texas at Austin, with the region offering ample opportunities to capture and store carbon, and recent state and federal incentives giving an added push to get started. Carbon capture and storage, or CCS, is a technology that keeps CO2 out of the atmosphere by capturing emissions and storing them deep underground. It can help fight climate change by lowering industrial emissions now while renewable energy sources are being developed, said Tip Meckel, a senior research scientist at the Gulf Coast Carbon Center, a research group at the UT Bureau ...

LAST 30 PRESS RELEASES:

Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Low LDL cholesterol levels linked to reduced risk of dementia

Thickening of the eye’s retina associated with greater risk and severity of postoperative delirium in older patients

Almost one in ten people surveyed report having been harmed by the NHS in the last three years

Enhancing light control with complex frequency excitations

New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients

New insight into factors associated with a common disease among dogs and humans

Illuminating single atoms for sustainable propylene production

New study finds Rocky Mountain snow contamination

Study examines lactation in critically ill patients

UVA Engineering Dean Jennifer West earns AIMBE’s 2025 Pierre Galletti Award

Doubling down on metasurfaces

New Cedars-Sinai study shows how specialized diet can improve gut disorders

Making moves and hitting the breaks: Owl journeys surprise researchers in western Montana

PKU Scientists simulate the origin and evolution of the North Atlantic Oscillation

ICRAFT breakthrough: Unlocking A20’s dual role in cancer immunotherapy

How VR technology is changing the game for Alzheimer’s disease

A borrowed bacterial gene allowed some marine diatoms to live on a seaweed diet

Balance between two competing nerve proteins deters symptoms of autism in mice

Use of antifungals in agriculture may increase resistance in an infectious yeast

Awareness grows of cancer risk from alcohol consumption, survey finds

The experts that can outsmart optical illusions

Pregnancy may reduce long COVID risk

Scientists uncover novel immune mechanism in wheat tandem kinase

Three University of Virginia Engineering faculty elected as AAAS Fellows

Unintentional drug overdoses take a toll across the U.S. unequally, study finds

A step toward plant-based gelatin

ECMWF unveils groundbreaking ML tool for enhanced fire prediction

The food and fuel that farms itself

Patient- and Community-Level Characteristics Associated With RSV Vaccination

[Press-News.org] Snap, crackle, pop: Bone marrow-derived fibrin clot as better source for meniscal repair
Osaka City University shows that bone marrow-derived fibrin clots contain more growth factors than peripheral blood and better fit for meniscal repair surgery