(Press-News.org) Researchers developed a new risk equation, based on six routinely available patient parameters, that yielded improved performance in estimating the risk of a chronic kidney disease (CKD) patient to progress to end-stage kidney disease (ESKD) requiring kidney replacement therapy (KRT).
A novel risk equation for the timely identification of chronic kidney disease (CKD) patients at risk for progressing to kidney failure requiring kidney replacement therapy was developed in 4,915 patients with CKD stage 1-5 with and without albuminuria, from the German Chronic Kidney Disease (GCKD) Study. It includes six laboratory tests: serum creatinine, albumin, cystatin C, and urea, in addition to hemoglobin and the urine albumin-to-creatinine ratio. The newly derived 6-variable (Z6) risk score achieved high predictive performance and good calibration both in a resampling approach in the GCKD study and in three independent validation cohorts that included a total of 3,063 patients with CKD. Implementation of this risk equation in clinical practice holds promise for enhanced patient care.
INFORMATION:
American Journal of Kidney Diseases (AJKD)
ARTICLE TITLE: A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests
AUTHORS: Helena U. Zacharias, PhD, Michael Altenbuchinger, PhD, Ulla T. Schultheiss, MD, Johannes Raffler, PhD, Fruzsina Kotsis, MD, Sahar Ghasemi, MSc, Ibrahim Ali, MBBS, MSc, Barbara Kollerits, PhD, MPH, Marie Metzger, PhD, Inga Steinbrenner, MSc, Peggy Sekula, PhD, Ziad A. Massy, MD, Christian Combe, MD, PhD, Philip A. Kalra, MD, Florian Kronenberg, MD, Bénédicte Stengel, MD, PhD, Kai-Uwe Eckardt, MD, Anna Köttgen, MD, MPH, Matthias Schmid, PhD, Wolfram Gronwald, PhD, Peter J. Oefner, MD, PhD, on behalf of the GCKD investigators
DOI: https://doi.org/10.1053/j.ajkd.2021.05.018
TUCSON, Ariz., July 20, 2021 -- The use of digital health technologies across health care and drug development has accelerated. A new paper titled "Digital Progression Biomarkers as Novel Endpoints in Clinical Trials: A Multistakeholder Perspective," co-authored by experts across diverse disciplines, highlights how new remote monitoring technologies present a tremendous opportunity to advance digital medicine in health care even further, specifically in Parkinson's disease. This perspective paper is co-authored by the academic leader of the largest funded project for digital technologies in Europe, Professor Lynn Rochester, University of Newcastle; European Medicines Agency (EMA) ...
Researchers revealed new insights into how acute myeloid leukemia (AML) develops and progresses, according to a study published in END ...
For children with Type 1 diabetes, the risk of experiencing a severe hypoglycemic episode is especially common -- and for parents, the threat of that happening in the middle of the night is especially frightening. Sudden and critical drops in blood sugar can go undetected overnight when the child is asleep, resulting in coma and death -- an event known as "dead in bed syndrome."
"A parent can check their child's glucose levels right before they go to bed and everything looks fine, then around 2 a.m. their blood sugar is dangerously low -- near comatose level," said Matthew Webber, associate professor of chemical and ...
WASHINGTON (July 20, 2021)--A new study of COVID-19 shutdowns in the United States reveals pronounced disparities in air pollution -- with disenfranchised, minority neighborhoods still experiencing more exposure to a harmful air pollutant compared to wealthier, white communities. This first-of-a-kind study published today by researchers at the George Washington University looks at how air pollution changed after schools and businesses shut down in March 2020 in attempts to curb the spread of COVID-19.
"New York and other major urban areas had cleaner air as many commuters and others stayed off the roads," Gaige Kerr, the lead researcher on the study and a research scientist at the GW Milken ...
Researchers want sexual assault survivors to know that it's normal to feel awful right after the assault, but that many will feel better within three months.
In a meta-analysis published in Trauma, Violence & Abuse, researchers found that 81% of sexual assault survivors had significant symptoms of post-traumatic stress (PTSD) one week after the assault. One month afterward - the first point in time that PTSD can be diagnosed - 75% of sexual assault survivors met criteria for the disorder. That figure dropped to 54% after three months and 41% after one year.
"One of the main takeaways is that the majority of recovery from post-traumatic stress happens in first three months," ...
LAWRENCE -- A new paper appearing the Proceedings of the National Academy of Sciences gives new detail and understanding to the cultivation of corn, one of the United States' biggest cash crops.
The research by a team at the University of Kansas centers on "hybrid vigor," also known as "heterosis," a well-known phenomenon where crosses between inbred lines of corn and other crops produce offspring that outperform their parents in yield, drought resistance and other desirable qualities. Yet, the mechanisms underpinning heterosis are little understood despite over a century of intensive research.
The new PNAS research examines the relationship between heterosis and soil microbes, showing, ...
Ten years after one of the largest nuclear accidents in history spewed radioactive contamination over the landscape in Fukushima, Japan, a University of Georgia study has shown that radioactive contamination in the Fukushima Exclusion Zone can be measured through its resident snakes.
The team's findings, published in the recent journal of Ichthyology & Herpetology, report that rat snakes are an effective bioindicator of residual radioactivity. Like canaries in a coal mine, bioindicators are organisms that can signal an ecosystem's health.
An abundant species in Japan, rat snakes travel short distances and can accumulate high levels of radionuclides. According ...
A recent study led by Geoff Burns, an elite runner and postdoctoral researcher at the University of Michigan Exercise & Sport Science Initiative, compared the "bouncing behavior"--the underlying spring-like physics of running--in elite-level male runners (sub-four-minute milers) vs. highly trained but not elite runners.
Subjects ran on a treadmill instrumented with a pressure plate beneath the belt, so Burns and colleagues could see how much time they spent in the air and in contact with the ground. When running, muscles and limbs coordinate to act like a giant pogo stick, and those muscles, tendons and ligaments interact to recycle energy from step to step, Burns says.
The researchers looked at the basic physics of the runners ...
Routine adolescent preventive visits provide important opportunities for promoting sexual and reproductive health and for preventing unintended pregnancy and sexually transmitted infections.
A new study END ...
We all like to think that we know ourselves best, but, given that our brain activity is largely governed by our subconscious mind, it is probably our brain that knows us better! While this is only a hypothesis, researchers from Japan have already proposed a content recommendation system that assumes this to be true. Essentially, such a system makes use of its user's brain signals (acquired using, say, an MRI scan) when exposed to a particular content and eventually, by exploring various users and contents, builds up a general model of brain activity.
"Once we obtain the 'ultimate' brain model, we should be able to perfectly estimate the brain activity of ...
