PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Digital health technologies hold key to new Parkinson's treatments

Global stakeholders come together to collaborate with urgency to address unmet needs for Parkinson's therapies

2021-07-20
(Press-News.org) TUCSON, Ariz., July 20, 2021 -- The use of digital health technologies across health care and drug development has accelerated. A new paper titled "Digital Progression Biomarkers as Novel Endpoints in Clinical Trials: A Multistakeholder Perspective," co-authored by experts across diverse disciplines, highlights how new remote monitoring technologies present a tremendous opportunity to advance digital medicine in health care even further, specifically in Parkinson's disease. This perspective paper is co-authored by the academic leader of the largest funded project for digital technologies in Europe, Professor Lynn Rochester, University of Newcastle; European Medicines Agency (EMA) scientific leader, Dr. Maria Tome; young investigator and Ph.D. candidate Reham Badawy; physician and Parkinson's patient, Dr. Soania Mathur; and Dr. Diane Stephenson, Executive Director of the Critical Path for Parkinson's (CPP) Consortium.

Global collaborative efforts are underway with the goal of advancing the use of digital health technologies for use in Parkinson's clinical research and therapeutic trials -- yet several gaps and barriers stand in the way of success. These include data security issues, the rapidly evolving nature of the technology, lack of consensus on data standards, vast diversity of distinct studies carried out on different devices and the need for open science.

CPP's Digital Drug Development Tool team at Critical Path Institute consists of industry members, scientific academic advisors, patient research organizations and people living with Parkinson's all collaborating across the globe to seek advice early and often from regulatory agencies. Companies advancing innovative therapies for the treatment of Parkinson's see the promise of digital technologies, yet they also recognize that there are gaps that are too challenging to overcome on their own. CPP's focus on the voice of people living with Parkinson's aligns with the U.S. Food and Drug Administration (FDA) and EMA's vision for patient-focused drug development. Sharing costs, risks and knowledge will streamline a more efficient runway for regulatory endorsement in the future.

"We felt it was imperative to come together on this paper, at this moment, to bring attention to how existing digital health technologies can complement traditional modalities and transform and accelerate clinical research and therapeutic development," said Rochester.

Dr. Mathur, who has lived with Parkinson's for 22 years, inspired the team of five women leaders to work on this paper across different countries during the pandemic. "It is vital to include the patient voice to drive the sense of urgency when it comes to Parkinson's research. As patients, we fully experience the unrelenting progression of this disease, the ongoing daily challenges that we live with. From the direction of research to identifying the tools that can estimate relevant outcome measures in the search for new therapeutics that are directed towards disease modification or improved quality of life, patient input is absolutely integral to its success. This collaboration kept that sense of urgency at the forefront."

"EMA works with the FDA to assure that digital technologies are aligned with what is important to patients," said Dr. Tome. "The pace of progress is going to be accelerated by applying principles of what it took the world to tackle the COVID-19 pandemic," Stephenson added. "True collaborations amongst all stakeholders are urgently needed to make efficient progress, avoid duplication of effort, share costs and risks and advance with warp speed."

Professor Bas Bloem, editor-in-chief of the Journal of Parkinson's Disease and author of the book "Ending Parkinson's Disease" said, "We are very excited to publish this very important paper in our journal, as it provides a clear and visionary glimpse into the future of better care and innovative research approaches in the field of Parkinson's disease."

INFORMATION:

The paper is featured in Journal of Parkinson's dedicated issue Digital Health in Parkinson's Disease here https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd202428. For more information, visit CPP's website or read Digital Technology Driving Tangible Advancements in Parkinson's Disease Research and Clinical Care.

Critical Path Institute is supported by the Food and Drug Administration (FDA) of the U.S. Department of Health and Human Services (HHS) and is 56.5% funded by FDA/HHS, totaling $16,749,891, and 43.5% funded by non-government source(s), totaling $12,895,366. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, FDA/HHS or the U.S. Government. For more information, please visit FDA.gov.

The views expressed in this release are the personal views of the authors and may not reflect the position of the various groups or parties represented.

About CPP

Created in partnership with Parkinson's UK, one of the world's largest charity funders of Parkinson's research, the Critical Path for Parkinson's Consortium was launched on October 14, 2015. This is a global collaboration that promises to pave the path to new treatments for Parkinson's. By facilitating collaboration among scientists from the bio-pharmaceutical industry, academic institutions, government agencies, and patient-advocacy associations, CPP fosters consensus and data-driven research to increase efficiency, safety, and speed in developing new therapies.

About C-Path

Critical Path Institute (C-Path) is an independent, nonprofit organization established in 2005 as a public and private partnership. C-Path's mission is to catalyze the development of new approaches that advance medical innovation and regulatory science, accelerating the path to a healthier world. An international leader in forming collaborations, C-Path has established numerous global consortia that currently include more than 1,600 scientists from government and regulatory agencies, academia, patient organizations, disease foundations, and dozens of pharmaceutical and biotech companies. C-Path U.S. is headquartered in Tucson, Arizona and C-Path, Ltd. EU is headquartered in Dublin, Ireland, with additional staff in multiple other locations. For more information, visit c-path.org and c-path.eu.



ELSE PRESS RELEASES FROM THIS DATE:

New discoveries reveal how acute myeloid leukemia walks line between growth and cell death

2021-07-20
Researchers revealed new insights into how acute myeloid leukemia (AML) develops and progresses, according to a study published in END ...

Researchers develop novel method for glucagon delivery

Researchers develop novel method for glucagon delivery
2021-07-20
For children with Type 1 diabetes, the risk of experiencing a severe hypoglycemic episode is especially common -- and for parents, the threat of that happening in the middle of the night is especially frightening. Sudden and critical drops in blood sugar can go undetected overnight when the child is asleep, resulting in coma and death -- an event known as "dead in bed syndrome." "A parent can check their child's glucose levels right before they go to bed and everything looks fine, then around 2 a.m. their blood sugar is dangerously low -- near comatose level," said Matthew Webber, associate professor of chemical and ...

COVID-19 shutdowns reveal racial disparities in exposure to air pollution

COVID-19 shutdowns reveal racial disparities in exposure to air pollution
2021-07-20
WASHINGTON (July 20, 2021)--A new study of COVID-19 shutdowns in the United States reveals pronounced disparities in air pollution -- with disenfranchised, minority neighborhoods still experiencing more exposure to a harmful air pollutant compared to wealthier, white communities. This first-of-a-kind study published today by researchers at the George Washington University looks at how air pollution changed after schools and businesses shut down in March 2020 in attempts to curb the spread of COVID-19. "New York and other major urban areas had cleaner air as many commuters and others stayed off the roads," Gaige Kerr, the lead researcher on the study and a research scientist at the GW Milken ...

75% of sexual assault survivors have PTSD one month later

2021-07-20
Researchers want sexual assault survivors to know that it's normal to feel awful right after the assault, but that many will feel better within three months. In a meta-analysis published in Trauma, Violence & Abuse, researchers found that 81% of sexual assault survivors had significant symptoms of post-traumatic stress (PTSD) one week after the assault. One month afterward - the first point in time that PTSD can be diagnosed - 75% of sexual assault survivors met criteria for the disorder. That figure dropped to 54% after three months and 41% after one year. "One of the main takeaways is that the majority of recovery from post-traumatic stress happens in first three months," ...

Research shows microbes play critical role boosting vigor of hybrid corn

Research shows microbes play critical role boosting vigor of hybrid corn
2021-07-20
LAWRENCE -- A new paper appearing the Proceedings of the National Academy of Sciences gives new detail and understanding to the cultivation of corn, one of the United States' biggest cash crops. The research by a team at the University of Kansas centers on "hybrid vigor," also known as "heterosis," a well-known phenomenon where crosses between inbred lines of corn and other crops produce offspring that outperform their parents in yield, drought resistance and other desirable qualities. Yet, the mechanisms underpinning heterosis are little understood despite over a century of intensive research. The new PNAS research examines the relationship between heterosis and soil microbes, showing, ...

Using snakes to monitor Fukushima radiation

Using snakes to monitor Fukushima radiation
2021-07-20
Ten years after one of the largest nuclear accidents in history spewed radioactive contamination over the landscape in Fukushima, Japan, a University of Georgia study has shown that radioactive contamination in the Fukushima Exclusion Zone can be measured through its resident snakes. The team's findings, published in the recent journal of Ichthyology & Herpetology, report that rat snakes are an effective bioindicator of residual radioactivity. Like canaries in a coal mine, bioindicators are organisms that can signal an ecosystem's health. An abundant species in Japan, rat snakes travel short distances and can accumulate high levels of radionuclides. According ...

Elite runners spend more time in air, less on ground, than highly trained but nonelite peers

2021-07-20
A recent study led by Geoff Burns, an elite runner and postdoctoral researcher at the University of Michigan Exercise & Sport Science Initiative, compared the "bouncing behavior"--the underlying spring-like physics of running--in elite-level male runners (sub-four-minute milers) vs. highly trained but not elite runners. Subjects ran on a treadmill instrumented with a pressure plate beneath the belt, so Burns and colleagues could see how much time they spent in the air and in contact with the ground. When running, muscles and limbs coordinate to act like a giant pogo stick, and those muscles, tendons and ligaments interact to recycle energy from step to step, Burns says. The researchers looked at the basic physics of the runners ...

Health care providers missing opportunities to talk about sexual health with young people

2021-07-20
Routine adolescent preventive visits provide important opportunities for promoting sexual and reproductive health and for preventing unintended pregnancy and sexually transmitted infections. A new study END ...

Mind and matter: Modeling the human brain with machine learning

2021-07-20
We all like to think that we know ourselves best, but, given that our brain activity is largely governed by our subconscious mind, it is probably our brain that knows us better! While this is only a hypothesis, researchers from Japan have already proposed a content recommendation system that assumes this to be true. Essentially, such a system makes use of its user's brain signals (acquired using, say, an MRI scan) when exposed to a particular content and eventually, by exploring various users and contents, builds up a general model of brain activity. "Once we obtain the 'ultimate' brain model, we should be able to perfectly estimate the brain activity of ...

American Board of Urology outlines processes to ensure diversity in leadership

2021-07-20
July 19, 2021 - At the organization responsible for certifying the training and skills of US urologists, achieving and maintaining diversity, equity and inclusion is more than just a "numbers game," according to a special article in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. In the new article, the American Board of Urology (ABU) points out that the practice of diversity and inclusion has been a cornerstone of its values for years. However, the Board acknowledges that while progress has been made, ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Digital health technologies hold key to new Parkinson's treatments
Global stakeholders come together to collaborate with urgency to address unmet needs for Parkinson's therapies