PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

3D imaging reveals neural 'vicious cycle' in fatty liver disease

3D imaging reveals neural 'vicious cycle' in fatty liver disease
2021-07-22
(Press-News.org) With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The results are being published in the journal Science Advances.

Non-alcoholic fatty liver disease is the most common hepatic disorder, with prevalence around 25 percent globally. Approximately one third of all fatty liver cases will develop to steatohepatitis, which is a severe disease seriously affecting the entire metabolism.

In the current paper, researchers explore the nervous system in fatty liver using volume immuno-imaging and light sheet microscopy ? a novel imaging technique, which altogether offer large-scale 3D visualization with cellular resolution. According to the study, this technology can reveal even early, minor or hidden structural impairments of the liver.

"Now we know that nerves in the liver have multiple subtle regulatory roles" says Csaba Adori, researcher at the Department of Neuroscience, who led the study. "Their role, however, may be more essential during the fight-or-flight response or when subjected to metabolic challenges. Degeneration of liver sympathetic nerves and abnormal operation of the remaining nerve fibres in the fatty liver could compromise all these functions, which may contribute to further aggravation of the disease, as part of a vicious cycle."

According to the study, alterations in the liver innervation occurs already in early stages of fatty liver disease. With progression to the more severe steatohepatitis, these impairments turn to a pronounced degeneration of the nerves. The nerve pathology is also similar in mouse model of fatty liver and in human fatty liver samples. The research team now hopes that the study results will open the door for new therapeutic approaches in the treatment of steatohepatitis and portal hypertension, by targeting the liver sympathetic nervous system.

INFORMATION:

The study was supported by the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Sven Mattsson's Foundation, the Åhlén-Foundation and the NovoNordisk Foundation. Researchers from SciLifeLab, Karolinska University Hospital, and several universities in Sweden, Slovakia and USA also contributed to the study.

Publication: 'Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging', C. Adori, T. Daraio, R. Kuiper, S. Barde, L. Horvathova, T. Yoshitake, R. Ihnatko, I. Valladolid-Acebes, P. Vercruysse, A. M. Wellendorf, R. Gramignoli, B. Bozoky, J. Kehr, E. Theodorsson, J. A. Cancelas, B. Mravec, C. Jorns, E. Ellis, J. Mulder, M. Uhlén, C. Bark, T. Hökfelt, Science Advances, online 21 July 2021, doi: 10.1126/sciadv.abg5733

More about Karolinska Institutet -- a medical university: ki.se/en


[Attachments] See images for this press release:
3D imaging reveals neural 'vicious cycle' in fatty liver disease

ELSE PRESS RELEASES FROM THIS DATE:

Visualizing a city's energy use

Visualizing a citys energy use
2021-07-22
The building sector in the U.S. accounts for 39 percent of energy use, with commercial buildings responsible for about half of that. As cities grapple with climate change, making commercial buildings more efficient is a key part of the solution. Researchers at the University of Pittsburgh Swanson School of Engineering and the Mascaro Center for Sustainable Innovation used the City of Pittsburgh to create a model built upon the design, materials and purpose of commercial buildings to estimate their energy usage and emissions. While other models may ...

'Golden nail': Quarry near Salzgitter becomes global geological reference point

Golden nail: Quarry near Salzgitter becomes global geological reference point
2021-07-22
FRANKFURT/HANNOVER. The international team of geoscientists led by Prof. Silke Voigt from the Goethe University Frankfurt, Prof. Ireneusz Walaszczyk from the University of Warsaw and Dr André Bornemann from LBEG have thoroughly investigated 40 metres of the geological strata sequence in the former limestone quarry at Hasselberg. The researchers determined that this is only sequence in the transition between Turonian and Coniacian without gaps and it therefore represents a perfect rock sequence to serve geoscientists from all over the world as a reference for their research - a "Global Stratotype Section and Point (GSSP)" or, in the jargon of geosciences, a "golden nail". Certain group of bivalve mollusks of the family Inoceramidae, first appeared in the Coniacian, and ...

Disagreement may be a way to make online content spread faster, further

2021-07-22
ORLANDO, July 22, 2021 - Disagreement seems to spread online posts faster and further than agreement, according to a new study from the University of Central Florida. The finding comes from an examination of posts labeled controversial on social news aggregation site Reddit. To perform the study, the researchers analyzed more than 47,000 posts about cybersecurity in a Reddit dataset that was collected by the Computational Simulation of Online Social Behavior (SocialSim) program of the U.S. Defense Advanced Research Projects Agency. Researchers found that these posts were seen by nearly twice the number of people and traveled nearly twice as fast when compared ...

New insights into uncontrolled inflammation in COVID-19 patients

2021-07-22
In a new study, published recently in the journal Circulation Research, scientists discover how the production of protective molecules known as specialised pro-resolving mediators (SPM) is altered in patients with COVID-19. The results suggest that treatments which increase SPM production, such as dexamethasone or SPM based drugs, could play a key role in limiting inflammation in these patients. Currently there is little understanding around the mechanisms that lead to uncontrolled inflammation in patients with COVID-19. The study found a link between decreased SPM blood levels and disrupted white blood cell responses in patients with a higher disease burden. The findings also revealed that dexamethasone, the first drug ...

Informing policy for long-term global food security

2021-07-22
More than 820 million people in the world don't have enough to eat, while climate change and increasing competition for land and water are further raising concerns about the future balance between food demand and supply. The results of a new IIASA-led study can be used to benchmark global food security projections and inform policy analysis and public debate on the future of food. Despite the fact that food supply has increased dramatically since the 1960s, the question of how to eradicate global hunger - one of the Sustainable Development Goals - and feed the growing world population in years to come, remains a major challenge. Climate change and increasing competition ...

Cannabidiol promotes oral ulcer healing by inactivating CMPK2-mediated NLRP3 inflammasome

2021-07-22
Alexandria, Va., USA - Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session "Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The oral ulcer is a common oral inflammatory lesion with severe pain but little ...

Longitudinal serological and vaccination responses to SARS-COV-2 in dental professionals

2021-07-22
Alexandria, Va., USA - Iain Chapple, University of Birmingham, England, presented the oral session "Longitudinal Serological and Vaccination Responses to SARS-COV-2 in Dental Professionals" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The COVID-19 pandemic significantly impacted ...

New study reports strong indications of freshened groundwater offshore the Maltese Islands

New study reports strong indications of freshened groundwater offshore the Maltese Islands
2021-07-22
An international team of scientists has reported strong indications of freshened groundwater offshore the coastline between Valletta and Marsascala, in the south-east of Malta. This discovery is based on an oceanographic expedition carried out in 2018. Seismic reflection profiles acquired during this expedition were used to generate a geological model of the seafloor offshore the Maltese Islands, whereas electromagnetic surveying was carried out to identify resistivity anomalies, or high values of electromagnetic resistivity beneath the seafloor. These observations indicate that freshened groundwater occurs as an isolated body hosted in Globigerina Limestone located 3 ...

Burden of oral diseases in emerging countries: A prediction model

2021-07-22
Alexandria, Va., USA - Jiachen Lin, Harvard School of Dental Medicine, Boston, Mass., USA., presented the poster "Burden of Oral Diseases in Emerging Countries: A Prediction Model" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021. The goal of this study was to investigate the burden of oral diseases and predict trends by 2025 in the U.S. and emerging countries. Global Burden of Disease data from 1990-2017 was used to analyze the prevalence and disability-adjusted life years of oral diseases ...

Generation and application of the high-Q resonance in all-dielectric metasurfaces

Generation and application of the high-Q resonance in all-dielectric metasurfaces
2021-07-22
In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200030 , Researchers led by Professor Liu Yan from Xidian University, China and Professor Gan Xuetao from Northwestern Polytechnical University, China consider generation and application of the high-Q resonance in all-dielectric metasurfaces. Metamaterials are artificial composite electromagnetic structures consisting of subwavelength units, which can realize efficient and flexible control of the electromagnetic waves. Metamaterials are an emerging research area for optoelectronics, physics, chemistry and materials, due to their novel ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] 3D imaging reveals neural 'vicious cycle' in fatty liver disease