Surrey builds AI to find anti-ageing chemical compounds
2021-07-22
(Press-News.org) The University of Surrey has built an artificial intelligence (AI) model that identifies chemical compounds that promote healthy ageing - paving the way towards pharmaceutical innovations that extend a person's lifespan.
In a paper published by Nature Communication's Scientific Reports, a team of chemists from Surrey built a machine learning model based on the information from the DrugAge database to predict whether a compound can extend the life of Caenorhabditis elegans - a translucent worm that shares a similar metabolism to humans. The worm's shorter lifespan gave the researchers the opportunity to see the impact of the chemical compounds.
The AI singled out three compounds that have an 80 per cent chance of increasing the lifespan of elegans:
flavonoids (anti-oxidant pigments found in plants that promote cardiovascular health),
fatty acids (such as omega 3), and
Organooxygens (compounds that contain carbon to oxygen bonds, such as alcohol).
Sofia Kapsiani, co-author of the study and final year undergraduate student at the University of Surrey, said:
"Ageing is increasingly being recognised as a set of diseases in modern medicine, and we can apply the tools of the digital world, such as AI, to help slow down or protect against ageing and age-related diseases. Our study demonstrates the revolutionary ability of AI to aid the identification of compounds with anti-ageing properties."
Dr Brendan Howlin, lead author of the study and Senior Lecturer in Computational Chemistry at the University of Surrey, said:
"This research shows the power and potential of AI, which is a speciality of the University of Surrey, to drive significant benefits in human health."
INFORMATION:
Notes to editors
For a copy of the paper or to organise a call with the authors, please email d.njolinjo@Surrey.ac.uk
ELSE PRESS RELEASES FROM THIS DATE:
2021-07-22
Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy in his own home. The 53-year-old patient died from an unrelated injury about a month into the treatment, but during that short time, 31% of the tumor mass disappeared. The autopsy of his brain confirmed the rapid response to the treatment.
"Thanks to the courage of this patient and his family, we were able to test and verify the potential effectiveness of the first noninvasive therapy ...
2021-07-22
As a fourth-generation cattle farmer, Jared Decker knows that cattle suffer from health and productivity issues when they are taken from one environment -- which the herd has spent generations adapting to -- to a place with a different climate, a different elevation or even different grass. But as a researcher at the University of Missouri, Decker also sees an opportunity to use science to solve this problem, both to improve the welfare of cattle and to plug a leak in a nearly $50 billion industry in the U.S.
"When I joined MU in 2013, I moved cattle from a family farm in New Mexico to my farm here in Missouri," said Decker, an associate professor and Wurdack Chair in Animal Genetics at the College of Agriculture, Food and Natural Resources. "New Mexico is hot and dry, and Missouri is ...
2021-07-22
A computational analysis of COVID-19 tests suggests that, in order to minimize the number of infections in a population, the amount of testing matters more than the sensitivity of the tests that are used. Philip Cherian and Gautam Menon of Ashoka University in Sonipat, India, and Sandeep Krishna of the National Centre for Biological Sciences TIFR, Bangalore, India, present their findings in the open-access journal PLOS Computational Biology.
Different states in India use different mixes of two main tests for COVID-19: a very sensitive reverse-transcriptase polymerase-chain-reaction (RT-PCR) test and a less sensitive rapid antigen test. Traditional thinking holds that an all-RT-PCR approach ...
2021-07-22
The neurotransmitters GABA and glutamate have complementary roles -- GABA inhibits neurons, while glutamate makes them more active. Published 22nd July in PLOS Biology, researchers led by Roi Cohen Kadosh and George Zacharopoulos from the University of Oxford show that levels of these two neurotransmitters in the intraparietal sulcus of the brain can predict mathematics ability. The study also found that the relationships between the two neurotransmitters and arithmetic fluency switched as children developed into adults.
Levels of brain excitement/inhibition are thought to be related to learning, especially during critical periods. However, little is known about how they are related to complex learning that can take place over decades. To address this issue, the researchers ...
2021-07-22
For the first time, a team of international scientists have proven that cockatoos, an iconic Australian bird species, learn from each other a unique skill - lifting garbage bin lids to gather food. The world-first research published today in Science, confirms that cockatoos spread this novel behavior through social learning. Led by Barbara Klump and Lucy Aplin (Max Planck Institute of Animal Behavior), along with John Martin (Taronga Conservation Society) and Richard Major (Australian Museum), the team have shown that this behavior by cockatoos is actually ...
2021-07-22
Based on a dozen earthquakes detected on Mars by the SEIS very broadband seismometer, developed in France, the international team of NASA's InSight mission reveals the internal structure of Mars. The three studies published July 23 in Science, involving many co-authors from French institutions and laboratories, including CNRS, the Institut de Physique du Globe de Paris, Université de Paris, and supported by CNES and ANR, reveal, for the first time and thanks to the analysis of seismic waves, reflected and modified by these internal interfaces, an estimate of the size of the core, the thickness of the crust and the mantle structure. This is the first ...
2021-07-22
Osaka, Japan - Gross chromosomal rearrangements--where portions of the genome become moved, deleted, or inverted--can lead to cell death and diseases such as cancer in complex multicellular organisms. However, the details of how exactly these occur remain unknown. Now, studies in a single-celled organism called fission yeast have found evidence for the involvement of a protein called Rad8.
When DNA replicates or repairs itself, three copies of a protein called PCNA bind together and form a ring-like structure surrounding the DNA strand. This ring structure acts like a clamp and slides along the DNA strand. The team showed that Rad8 attaches ...
2021-07-22
UNIVERSITY PARK, Pa. -- Infection with dengue virus makes mosquitoes more sensitive to warmer temperatures, according to new research led by Penn State researchers. The team also found that infection with the bacterium Wolbachia, which has recently been used to control viral infections in mosquitoes, also increases the thermal sensitivity of the insects. The findings suggest that global warming could limit the spread of dengue fever but could also limit the effectiveness of Wolbachia as a biological control agent.
"Dengue fever, a potentially lethal disease for which no treatment exists, is caused by a virus, spread by the bite of the mosquito Aedes aegypti. This mosquito is also responsible ...
2021-07-22
NOTICE: This summary has been updated to correct misspellings of the last names of both Perspective authors. The Perspective authors are Sanne Cottaar and Paula Koelemeijer. We apologize for our error.
The first direct seismic observations from NASA's InSight lander, presented in three studies in this issue, provide clues to the composition of Mars. Researchers across these studies report preliminary findings from the Insight mission and begin to map - for the first time - the interior of a planet apart from Earth. "These three studies provide important constraints on the present-day structure of Mars and are also key for improving our understanding of how the planet formed billions of years ago and ...
2021-07-22
In the suburbs of Sydney, Australia, sulphur-crested cockatoos routinely loot lidded household waste bins to scavenge for food. In a new study, researchers document the emergence and geographic spread of innovative bin-opening behaviors in urban parrot populations, revealing the presence of a complex social learning culture in these birds. What's more, this behavior appears to have emerged as a direct response to land-use change and urbanization, demonstrating how animal cultures could allow for local adaptation of urban animal populations in the Anthropocene. In animals, ecological novelty, including novelties unique ...
LAST 30 PRESS RELEASES:
[Press-News.org] Surrey builds AI to find anti-ageing chemical compounds
