PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

More U.S. prostate cancer patients choosing active surveillance

More U.S. prostate cancer patients choosing active surveillance
2023-04-03
(Press-News.org) The number of prostate cancer patients in the U.S. choosing active surveillance over surgery or radiation has rapidly increased since 2010, rising from 16% to 60% for low-risk patients and from 8% to 22% for patients with favorable intermediate-risk cancers, according to a study published today in JAMA Internal Medicine. 

 

Active surveillance includes actively monitoring prostate cancer for progression, with the intention to intervene with surgery or radiation therapy if the cancer progresses. 

 

It is the preferred treatment option for men with low-risk prostate cancer and an option for some men with favorable intermediate-risk prostate cancer.

 

“The study's findings are encouraging because it shows an increase in the proportion of men who benefit from active surveillance over time,” said lead author Bashir Al Hussein Al Awamlh, MD, a second-year Urologic Oncology fellow at Vanderbilt University Medical Center (VUMC).

 

“Our findings suggest that patients and physicians are increasingly becoming more comfortable with observing a subset of cancers with low-risk features, extending the benefits of surveillance to more men. However, there remains room for improvement in active surveillance uptake to reach similar rates as in some countries in Europe or Australia. Particularly in light of recent data demonstrating the safety of active surveillance in low-risk cancers,” he said.

 

Surveillance is thought to mitigate the adverse effects associated with treatment of these cancers, while remaining oncologically safe, according to senior author Jonathan Shoag, MD, associate professor of Urology at University Hospitals (UH) Seidman Cancer Center in Cleveland, UH Urology Institute and Case Western Reserve University.

 

“These data show that a diagnosis of prostate cancer no longer means a patient will undergo treatment,” Shoag said. “This further strengthens what are already compelling arguments that the benefits of screening for prostate cancer with PSA far outweigh the harms. We now can, and do, avoid treating cancers that we believe will behave indolently.”

 

VUMC researchers, in collaboration with University Hospitals and the National Cancer Institute, studied patients from 2010-2018 and found disparities by race and ethnicity, income and rurality in receiving active surveillance in the U.S.

 

Study authors used the Surveillance, Epidemiology and End Results (SEER) “Prostate with Watchful Waiting database” to identify men over 40 with low- and favorable intermediate-risk prostate adenocarcinoma from 2010-2018, as defined by the National Comprehensive Care Network.

 

The authors also found that Hispanic men, men with low income, and men residing in rural areas were less likely to choose or be offered active surveillance. 

 

“We would like to see the rising tide of active surveillance lift all boats,” said co-author Daniel Barocas, MD, MPH, FACS, William L. Bray Professor and Executive Vice Chair of Urology at VUMC.

 

 

 

 

END

[Attachments] See images for this press release:
More U.S. prostate cancer patients choosing active surveillance More U.S. prostate cancer patients choosing active surveillance 2

ELSE PRESS RELEASES FROM THIS DATE:

Double-slit experiment that proved the wave nature of light explored in time

Double-slit experiment that proved the wave nature of light explored in time
2023-04-03
Imperial physicists have recreated the famous double-slit experiment, which showed light behaving as particles and a wave, in time rather than space. The experiment relies on materials that can change their optical properties in fractions of a second, which could be used in new technologies or to explore fundamental questions in physics. The original double-slit experiment, performed in 1801 by Thomas Young at the Royal Institution, showed that light acts as a wave. Further experiments, however, showed that light actually ...

Researchers show lorlatinib is safe and effective for patients with ALK-driven relapsed/refractory high-risk neuroblastoma

2023-04-03
Philadelphia, April 3, 2023—In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children’s Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma. The findings, published today in Nature Medicine, have led to a major amendment in a phase 3 Children’s Oncology Group (COG) clinical trial, which has incorporated lorlatinib for newly diagnosed ALK-driven high-risk neuroblastoma, ...

Hidden ice melt in Himalaya: Study

Hidden ice melt in Himalaya: Study
2023-04-03
A new study reveals that the mass loss of lake-terminating glaciers in the greater Himalaya has been significantly underestimated, due to the inability of satellites to see glacier changes occurring underwater, with critical implications for the region's future projections of glacier disappearance and water resources. Published in Nature Geoscience on April 3, the study was conducted by an international team including researchers from the Chinese Academy of Sciences (CAS), Graz University of Technology (Austria), the University of St. Andrews (UK), and Carnegie Mellon ...

Hannover Messe: Smart films help to make loudspeakers lighter and more energy-efficient

Hannover Messe: Smart films help to make loudspeakers lighter and more energy-efficient
2023-04-03
Professors Stefan Seelecke and Paul Motzki at Saarland University are developing intelligent materials that are opening up new avenues in sound reproduction technology: lightweight loudspeakers that use far less energy than their conventional counterparts, novel shapes for sound and signal generators and applications involving noise cancelling textiles. The basis for these smart materials are ultrathin silicone films that can act as artificial muscles with their own built-in sensors. The research team will be showcasing their new technology at this year’s Hannover Messe from 17 to 21 April (Hall 2, Stand B34). Ultrathin films may well replace the heavy and power-thirsty ...

LSU Health New Orleans LA Tumor Registry releases 6th Census Tract Cancer Incidence Report

LSU Health New Orleans LA Tumor Registry releases 6th Census Tract Cancer Incidence Report
2023-04-03
            New Orleans, LA -- LSU Health New Orleans Louisiana Tumor Registry (LTR) has published the sixth report of statewide cancer incidence rates by census tract. The publication, which reports 2010-2019 combined cancer incidence data, found that 81% of the census tracts in Louisiana met publication criteria for all cancers combined. For specific cancer types, fewer census tracts met the criteria. For the Louisiana census tracts meeting the criteria, the incidence rates for all cancers combined and for specific cancer types were compared with the corresponding rates for the entire state. The ...

Anticancer drugs with fewer side-effects: scientists decode the crystal structure of a key cell cycle protein

Anticancer drugs with fewer side-effects: scientists decode the crystal structure of a key cell cycle protein
2023-04-03
Anticancer drugs are pivotal to cancer treatment, but their toxicity may not always be limited to cancer cells, resulting in harmful side-effects. To develop anticancer therapies that have fewer adverse effects on patients, scientists are now focusing on molecules that are less toxic to cells. One such group of drugs is the "kinesin inhibitors." These inhibitors prevent cancer progression by explicitly targeting kinesin motor proteins, which are required for the division of cancer cells. Centromere-associated protein E (CENP-E), a member of the kinesin motor protein, is a promising target for inhibitor therapy, as it is essential for tumor cell replication. However, determining the ...

Researchers reviewed recent progress of organic room-temperature phosphorescent materials towards application

Researchers reviewed recent progress of organic room-temperature phosphorescent materials towards application
2023-04-03
Organic materials with room-temperature phosphorescence (RTP) emission have attracted extensive attention due to extraordinary properties including long lifetime, large Stokes shift, stimuli-responsiveness, and so on, and show bright prospects in broad fields. However, the energy of the excited state of organic phosphors is easily consumed through thermal radiation and collision deactivation. Therefore, numerous design strategies such as creating a rigid environment through crystallization and supramolecular assembly are employed to improve the luminescent characteristics of RTP materials by restricting nonradiative transition, enhancing intersystem crossing, and so forth. A team ...

American Kidney Fund awards fellowships to researchers focused on barriers to home dialysis and living donor transplants among youth; COVID-19 vaccine booster disparities in the dialysis community

2023-04-03
ROCKVILLE, Md. (April 3, 2023)— Today the American Kidney Fund (AKF) announced the recipients of this year’s Clinical Scientist in Nephrology (CSN) fellowship program, in which promising researchers work to improve the quality of care for people living with kidney disease and promote clinical research in nephrology. Dr. Alexandra Bicki, a pediatric nephrology fellow at the University of California, San Francisco, will be working on identifying facilitators and barriers to home dialysis and living kidney donor transplantation among adolescents and young adults, while Dr. Nivetha Subramanian, a nephrology fellow at ...

SwRI expands hydrogen energy research capabilities with new liquid hydrogen storage tank

SwRI expands hydrogen energy research capabilities with new liquid hydrogen storage tank
2023-04-03
SAN ANTONIO – April 3, 2023 — Southwest Research Institute has installed a large-capacity liquid hydrogen tank to expand its advanced hydrogen energy research initiatives. Leveraging the tank’s capabilities alongside a multidisciplinary research approach, SwRI endeavors to explore technology opportunities and address obstacles related to hydrogen energy research and development. The SwRI liquid hydrogen storage tank has a capacity of 17,000 gallons and will provide the Institute with a cost-effective, reliable supply of hydrogen ...

International research team analyzes February 2023 Ohio train derailment

International research team analyzes February 2023 Ohio train derailment
2023-04-03
On February 3, 2023, a train derailed in the United States near East Palestine, Ohio, leading to the combustion of vinyl chloride. Following that accident, an international team of researchers undertook an in-depth analysis of the environmental consequences of the accident. Their analysis is published in the journal Frontiers of Environmental Science & Engineering on March 15, 2023. In their analysis, the team examined a series of questions related to the environmental risk and management of the chemical accident. “We emphasized that it is unscientific to overestimate or underestimate the environmental ...

LAST 30 PRESS RELEASES:

Electrons reveal their handedness in attosecond flashes

Research implicates biomolecular condensates in a type of childhood brain cancer

AUF1 protein plays anti-aging role by regulating cellular metabolism

How Iceland’s fiery mantle plume scattered ancient volcanoes across the North Atlantic

Many patients with advanced cancer feel their treatment is not aligned with their personal care goals

Older species tend to have large ranges – unless they live on islands

Glow-in-the-dark succulents that recharge with sunlight

Origin of life breakthrough: Chemists show how RNA might have started to make proteins on early Earth

Partial heart transplant for congenital heart disease

Two big steps toward the evolution of bipedality

Use of glucagon-like peptide-1 agonists among individuals undergoing bariatric surgery in the US

Global inequities in diabetes technology and insulin access and glycemic outcomes

New fossils show how “bizarre” armoured dinosaur, Spicomellus afer, had 1 metre spikes sticking out from its neck

UCLA scientists uncover brain network controlling stress and social behavior in mice

Housing aid linked to lower medical financial hardship among U.S. renters with cancer

The no surprises act has reduced patients’ out-of-pocket spending for medical care

Association between serum 25-hydroxyvitamin D levels and skin cancer risk

Molecular Analysis for Precision Oncology Congress (MAP) 2025: Event Announcement

Unmasking inflammatory bowel disease in nigeria: a multicenter cross-sectional analysis of clinico-pathological and endoscopic findings

Gene therapy leads to improved quality of life in patients with sickle cell disease and beta thalassemia

Seroprevalence 36 months after a single-dose bivalent human papillomavirus vaccination among nine to fifteen-year-old girls in Dhaka, Bangladesh

In a challenging labor market, Black women with disabilities are choosing self-employment

SwRI develops an ion-assisted chromatography process to accelerate drug development

Local news services need to adapt or face extinction: report

Myocardial infarction may be an infectious disease

Access to four-year colleges that effectively serve low-income students is uneven across U.S., new study finds

American Meteorological Society announces 2026 weather, water, and climate honorees

Transcutaneous vagal nerve stimulation for gastrointestinal disorders

WSU study suggests returning students didn’t drive COVID-19 outbreaks in town

CURE GABA-A announces GABRA1 proof-of-concept for nanolipid particle therapy with Grann Pharmaceuticals

[Press-News.org] More U.S. prostate cancer patients choosing active surveillance