PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Moderate exercise safe for people with muscle pain from statins

Statins do not increase muscle injury after prolonged walking, important for heart health in statin users

2023-04-03
(Press-News.org) Statin therapy does not exacerbate muscle injury, pain or fatigue in people engaging in moderate-intensity exercise, such as walking, according to a study published today in the Journal of the American College of Cardiology. The findings are reassuring for people who experience muscle pain or fatigue from statins but need to engage in physical activity to keep their cholesterol levels low and their hearts healthy.

Statins have long been the gold standard for lowering LDL or “bad” cholesterol and preventing cardiovascular disease (CVD) events, but while generally well-tolerated, they can cause muscle pain and weakness in some. Physical activity is also a cornerstone of CVD prevention, especially when combined with statins; however, studies have shown vigorous exercise can increase muscle damage in some statin users, which can lead to decreased physical activity or cause people to stop taking their medication. Less is known about the impact of moderate exercise.

Researchers sought to compare the impact of moderate-intensity exercise on muscle injury in symptomatic and asymptomatic statin users, plus nonstatin using controls. Symptomatic vs. asymptomatic was determined by the presence, localization and onset of muscle cramps, pain and/or weakness using the statin myalgia clinical index score. Researchers also examined the association between leukocyte CoQ10 levels on muscle injury and muscle complaints, since statins may lower CoQ10 levels and reduced levels can predispose people to muscle injury.

All study participants walked 30, 40 or 50 km (18.6, 24.8 or 31 miles, respectively) per day at a self-selected pace for four consecutive days. Statin users had all been on the medication for at least three months. The researchers excluded those with diabetes, hypo- or hyperthyroidism, known hereditary skeletal muscle defects, other diseases known to cause muscle symptoms or those using CoQ10 supplementation. There were no differences in body mass index, waist circumference, physical activity levels or vitamin D3 levels (low vitamin D3 levels have been associated with statin-induced myopathy and therefore may be a risk-factor for statin-associated muscle symptoms) among the three groups at baseline.

Researchers found that statins did not exacerbate muscle injury or muscle symptoms after moderate-intensity exercise.

“Even though muscle pain and fatigue scores were higher in symptomatic statin users at baseline, the increase in muscle symptoms after exercise was similar among the groups,” said Neeltje Allard, MD, first author of the study and researcher at the Department of integrative physiology, Radboud University Medical Center in Nijmegen, Netherlands. “These results demonstrate that prolonged moderate-intensity exercise is safe for statin users and can be performed by statin users to maintain a physically active lifestyle and to derive its cardiovascular health benefits.”

Researchers did not find a correlation between leukocyte CoQ10 levels and muscle injury markers at baseline or after exercise nor was there a correlation between CoQ10 levels and muscle fatigue resistance or muscle pain scores.

In an accompanying editorial comment, Robert Rosenson, MD, Director of Metabolism and Lipids for the Mount Sinai Health System in New York, said patients experiencing statin associated muscle symptoms will often avoid exercise because of muscle pain and weakness and concerns of making the pain worse; however, exercise is essential for restoring and maintaining fitness in people at increased risk for cardiovascular disease or who have had a cardiovascular event.

“[Based on the study], many patients who develop statin associated muscle symptoms may engage in a moderately intensive walking program without concern for worsened muscle biomarkers or performance,” he said.

The American College of Cardiology (ACC) is the global leader in transforming cardiovascular care and improving heart health for all. As the preeminent source of professional medical education for the entire cardiovascular care team since 1949, ACC credentials cardiovascular professionals in over 140 countries who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. Through its world-renowned family of JACC Journals, NCDR registries, ACC Accreditation Services, global network of Member Sections, CardioSmart patient resources and more, the College is committed to ensuring a world where science, knowledge and innovation optimize patient care and outcomes. Learn more at www.ACC.org or follow @ACCinTouch.

The ACC’s family of JACC Journals rank among the top cardiovascular journals in the world for scientific impact. The flagship journal, the Journal of the American College of Cardiology (JACC) — and family of specialty journals consisting of JACC: Advances, JACC: Asia, JACC: Basic to Translational Science, JACC: CardioOncology, JACC: Cardiovascular Imaging, JACC: Cardiovascular Interventions, JACC: Case Reports, JACC: Clinical Electrophysiology and JACC: Heart Failure — pride themselves on publishing the top peer-reviewed research on all aspects of cardiovascular disease. Learn more at JACC.org.

###

END



ELSE PRESS RELEASES FROM THIS DATE:

NC State researchers assemble pathogen ‘tree of life’

NC State researchers assemble pathogen ‘tree of life’
2023-04-03
A new online tool – the first of its kind for plant pathogens – will help researchers across the globe identify, detect and monitor species of Phytophthora, which have been responsible for plant diseases ranging from the devastating 1840s Irish potato famine to sudden oak death that still plagues West Coast oak population.  The new pathogen “tree of life” provides a plethora of information about each of the more than 192 formally described species – including their evolutionary history and relationships within groups – as well as more than 30 other informally described taxa. It also includes ...

National Institute of Dental and Craniofacial Research marks 75th anniversary

2023-04-03
Alexandria, VA – A symposium to kick off the year-long celebration of the 75th Anniversary of the National Institute of Dental and Craniofacial Research (NIDCR) was featured at the 52nd Annual Meeting & Exhibition of the AADOCR, held in conjunction with the 47th Annual Meeting of the CADR. The AADOCR/CADR Annual Meeting & Exhibition took place at the Oregon Convention Center in Portland on March 15-18, 2023. The symposium explored a brief history of the founding of NIDCR and its early activities, followed by reflections of the former directors, Harold C. Slavkin, Lawrence A. Tabak and Martha ...

AADOCR announces 2023 AADOCR Hatton Competition and Award Winners

2023-04-03
Alexandria, VA – The American Association for Dental, Oral, and Craniofacial Research (AADOCR) has announced the winners of the 2023 AADOCR Hatton Competition. The winners were recognized during the Opening Ceremonies of the 52nd Annual Meeting of the AADOCR, which was held in conjunction with the 47th Annual Meeting of the Canadian Association for Dental Research (CADR), that took place on March 15, 2023. The Hatton Award was first presented as the "Novice Award" in 1953 and is the oldest IADR/AADOCR ...

AADOCR announces Winners of the 2023 AADOCR/CADR Joseph Lister Award for New Investigators

2023-04-03
Alexandria, VA – The American Association for Dental, Oral, and Craniofacial Research (AADOCR) has announced the winners of the 2023 AADOCR/CADR Joseph Lister Award for New Investigators. The winners were recognized during the Opening Ceremonies of the 52nd Annual Meeting of the AADOCR, which was held in conjunction with the 47th Annual Meeting of the Canadian Association for Dental Research (CADR), that took place on March 15, 2023. First given in 2018, the AADOCR/CADR Joseph Lister Award for New Investigators is managed by AADOCR and supported by Johnson & Johnson Consumer, Inc. It was created to award young investigators ...

AADOCR announces Winners of the 2023 Student Competition for Advancing Dental Research Application (SCADA)

2023-04-03
Alexandria, VA – The American Association for Dental, Oral, and Craniofacial Research (AADOCR) has announced the winners of the 2023 Student Competition for Advancing Dental Research Application (SCADA). The winners were recognized during the Opening Ceremonies of the 52nd Annual Meeting of the AADOCR, which was held in conjunction with the 47th Annual Meeting of the Canadian Association for Dental Research (CADR), that took place on March 15, 2023. In 2017, AADOCR and Dentsply Sirona joined forces to co-sponsor SCADA, which was previously known as the Student Clinicians of ...

Smart watches could predict higher risk of heart failure

2023-04-03
Wearable devices such as smart watches could be used to detect a higher risk of developing heart failure and irregular heart rhythms in later life, suggests a new study led by UCL researchers. The peer-reviewed study, published in The European Heart Journal – Digital Health, looked at data from 83,000 people who had undergone a 15-second electrocardiogram (ECG) comparable to the kind carried out using smart watches and phone devices. The researchers identified ECG recordings containing extra heart beats which are usually benign but, if they occur frequently, are linked to conditions such as heart failure and arrhythmia ...

Cold is beneficial for healthy aging

Cold is beneficial for healthy aging
2023-04-03
Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. In recent years, studies on different model organisms have already shown that life expectancy increases significantly when body temperature is lowered. However, precisely how this works has still been unclear in many areas. A research team at the University of Cologne’s CECAD Cluster of Excellence in Aging Research has now unlocked one responsible mechanism. The study ‘Cold ...

Tiny eye movements are under a surprising degree of cognitive control

2023-04-03
A very subtle and seemingly random type of eye movement called ocular drift can be influenced by prior knowledge of the expected visual target, suggesting a surprising level of cognitive control over the eyes, according to a study led by Weill Cornell Medicine neuroscientists. The discovery, described Apr. 3 in Current Biology, adds to the scientific understanding of how vision—far from being a mere absorption of incoming signals from the retina—is controlled and directed by cognitive processes. “These ...

Griffin Charitable Foundation donates $71,000 to the Masonic Medical Research Institute

Griffin Charitable Foundation donates $71,000 to the Masonic Medical Research Institute
2023-04-03
UTICA, NY –A $71,000 donation by the Griffin Charitable Foundation, based in Rome, New York, was awarded to the Masonic Medical Research Institute (MMRI) to purchase a new state-of-the-art microscope for imaging cells. “It came as wonderful news that the Foundation pledged this generous donation,” said Stephen F. Izzo, MMRI’s Development Director. “This gift will make a profound impact on our research capabilities.”  The Griffin Charitable Foundation supports not-for-profit entities serving Rome and select organizations ...

Patients with schizophrenia have favorable surgical risk, opening the door for ethical consideration of neurosurgical interventions like Deep Brain Stimulation

2023-04-03
AURORA, Colo. (April 3, 2023) – A study published in Frontiers in Surgery finds that people with schizophrenia (SZ) and schizoaffective disorder (SAD) have overall lower surgical risk than people with Parkinson’s disease, which is reassuring when considering potential surgical interventions such as Deep Brain Stimulation (DBS) for the treatment of SZ and SAD. DBS, a procedure that implants electrodes in the deeper structures of the brain connected to generators in the chest, is rare in treating SZ and ...

LAST 30 PRESS RELEASES:

New mathematical insights into Lagrangian turbulence

Clinical trials reveal promising alternatives to high-toxicity tuberculosis drug

Artificial solar eclipses in space could shed light on Sun

Probing the cosmic Dark Ages from the far side of the Moon

UK hopes to bolster space weather forecasts with Europe's first solar storm monitor

Can one video change a teen's mindset? New study says yes - but there’s a catch

How lakes connect to groundwater critical for resilience to climate change, research finds

Youngest basaltic lunar meteorite fills nearly one billion-year gap in Moon’s volcanic history

Cal Poly Chemistry professor among three U.S. faculty to be honored for contributions to chemistry instruction

Stoichiometric crystal shows promise in quantum memory

Study sheds light on why some prostate tumors are resistant to treatment

Tree pollen reveals 150,000 years of monsoon history—and a warning for Australia’s northern rainfall

Best skin care ingredients revealed in thorough, national review

MicroRNA is awarded an Impact Factor Ranking for 2024

From COVID to cancer, new at-home test spots disease with startling accuracy

Now accepting submissions: Special Collection on Cognitive Aging

Young adult literature is not as young as it used to be

Can ChatGPT actually “see” red? New results of Google-funded study are nuanced

Turning quantum bottlenecks into breakthroughs

Cancer-fighting herpes virus shown to be an effective treatment for some advanced melanoma

Eliminating invasive rats may restore the flow of nutrients across food chain networks in Seychelles

World’s first: Lithuanian scientists’ discovery may transform OLED technology and explosives detection

Rice researchers develop superstrong, eco-friendly materials from bacteria

Itani studying translation potential of secure & efficient software updates in industrial internet of things architectures

Elucidating the source process of the 2021 south sandwich islands tsunami earthquake

Zhu studying use of big data in verification of route choice models

Common autoimmune drug may help reverse immunotherapy-induced diabetes, UCLA study finds

Quantum battery device lasts much longer than previous demonstrations

Gamma knife stereotactic radiosurgery for brain metastases from ovarian cancer

Meet the “plastivore” caterpillars that grow fat from eating plastic

[Press-News.org] Moderate exercise safe for people with muscle pain from statins
Statins do not increase muscle injury after prolonged walking, important for heart health in statin users