Musashi 1 in breast cancer: Implications for dormancy and survival in bone marrow
2023-05-16
(Press-News.org)
“This study now links Msi 1 to PD-L1.”
BUFFALO, NY- May 16, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.”
Breast cancer (BC) stem cells (CSCs) resist treatment and can exist as dormant cells in tissues such as the bone marrow (BM). Years before clinical diagnosis, BC cells (BCCs) could migrate from the primary site where the BM niche cells facilitate dedifferentiation into CSCs. Additionally, dedifferentiation could occur by cell autonomous methods.
In this new study, researchers George R. Nahas, Lauren S. Sherman, Garima Sinha, Markos H. El Far, Andrew Petryna, Steven M. Munoz, Kimberly A. Silverio, Maran Shaker, Pujan Neopane, Veronica Mariotti, and Pranela Rameshwar from Rutgers New Jersey Medical School studied the role of the RNA-binding protein, Musashi I (Msi 1). They also analyzed its relationship with the T-cell inhibitory molecule programmed death-ligand 1 (PD-L1) in CSCs.
“We validated the link between Msi 1 and PD-L1 in CSCs [cancer stem cells] based on significant reduction of CSCs following Msi 1 knockdown.”
PD-L1 is expressed on triple negative BC and other cancers. Therefore, PD-L1 is an immune checkpoint that is a target in immune therapy for cancers. Msi 1 can support BCC growth through stabilization of oncogenic transcripts and modulation of stem cell-related gene expression. The researchers reported on a role for Msi 1 to maintain CSCs. They found that it seemed to occur by the differentiation of CSCs to more matured BCCs. This correlated with increased transition from cycling quiescence and reduced expression of stem cell-linked genes. CSCs co-expressed Msi 1 and PD-L1. Msi 1 knockdown led to a significant decrease in CSCs with undetectable PD-L1.
“This study has implications for Msi 1 as a therapeutic target, in combination with [an] immune checkpoint inhibitor. Such treatment could also prevent dedifferentiation of breast cancer to CSCs, and to reverse tumor dormancy. The proposed combined treatment might be appropriate for other solid tumors.”
Read the full study: DOI: https://doi.org/10.18632/aging.204620
Corresponding Author: Pranela Rameshwar
Corresponding Email: rameshwa@njms.rutgers.edu
Keywords: cancer stem cell, breast cancer, musashi 1, bone marrow, dormancy
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204620
About Aging-US:
Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at www.Aging-US.com and connect with us:
SoundCloud
Facebook
Twitter
Instagram
YouTube
LabTube
LinkedIn
Reddit
Pinterest
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
ELSE PRESS RELEASES FROM THIS DATE:
2023-05-16
Irvine, Calif., May 16, 2023 — The MGAT5 glycosylation enzyme plays a crucial role in brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for neural stem cells.
Neurons, astrocytes and oligodendrocytes are the final mature cells of the brain and spinal cord formed by neural stem cells. Each has distinct and key functions. Neurons transmit signals, astrocytes help modify those signals, and oligodendrocytes ...
2023-05-16
Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke.
A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has found a noninvasive and nonpharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function. Results of the work are published in the Proceedings ...
2023-05-16
The prize, now in its 10th year, is given annually to at least six early-career scientists based in the New York City area by The Pershing Square Sohn Cancer Research Alliance. Prizes are awarded to scientists who are pursuing innovative cancer research and taking risks that might preclude them from traditional funding. Winners receive $250,000 a year for up to three years and access to networking opportunities and an annual retreat with past winners.
For Dr. Simon, the prize will allow him to apply his knowledge as a neuroscientist to cancer research. “I'm not a traditional cancer biologist,” said Dr. ...
2023-05-16
A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers’ ability to escape from the immune system.
This study, published in Cell Reports, found that obesity helps to establish a type of tumor microenvironment that promotes tumor progression. How exactly this happens lies in the relationship between the saturated fatty acids, the STING-type-I interferon pathway, and NLRC3.
“We tend to think about the increased risks for gastrointestinal tumors, breast cancer, pancreatic cancer, and ovarian cancer when it comes to obesity,” ...
2023-05-16
If you are a third grader, your chances of growing up to be a computer scientist is likely to heavily depend on your gender — a situation Allison Master says is just plain wrong.
How can Master be certain? Because third grade girls are telling her so.
“Our new research addresses a big, longstanding issue in STEM education, that women are highly under-represented in fields like computer science. It’s actually one of the most challenging fields for women’s representation. Only about 20% of people who major in computer science are women,” said Master, assistant professor ...
2023-05-16
Researchers at the University of Michigan Rogel Cancer Center and the School of Dentistry identified a new metric to articulate the relationship between nerve density and oral cancer. The study, published in Clinical Cancer Research, a journal of the American Association for Cancer Research, investigated normalized nerve density to translate previous mechanistic studies into a context that could be used in the clinic.
“We are recognizing more and more that there's a very dynamic interaction between nerves and cancer cells in the tumor microenvironment,” said Nisha D’Silva, B.D.S., M.S.D, Ph.D., Donald Kerr Endowed Collegiate ...
2023-05-16
SEATTLE – (May 16, 2023) – Patients with cancer whose immune systems are being supported or rebuilt by bone marrow transplantation should begin receiving vaccines for protection against SARS-CoV-2 three months post-transplant, according to a large, prospective, observational study led collaboratively by the Center for International Blood and Marrow Transplant Research, the Blood & Marrow Transplant Clinical Trials Network and Fred Hutchinson Cancer Center. The research, involving 22 cancer centers and research institutions in the United States and focusing on mRNA-based vaccines, published in The Lancet journal ...
2023-05-16
Online workflow systems for off-site radiologists are one reason for health care delays that cost hospitals money and test the patience of patients, according to West Virginia University research.
Bernardo Quiroga, associate professor of supply chain management at the WVU John Chambers College of Business and Economics, and his coauthors analyzed a radiology workflow platform, used by thousands of U.S. hospitals, which allows radiologists working from home to log in, view a pool of tasks such as X-rays or CT and MRI scans that are available for processing, and choose which of those radiological studies to read and report on.
The radiologists’ ...
2023-05-16
Contact: Shelby Cefaratti-Bertin, Baylor University Media & Public Relations, 254-327-8012
Follow us on Twitter: @BaylorUMedi
WACO, Texas (May 15, 2023) – For most of U.S. history, tattoos have been associated with sailors and bikers, but not church-going people. As tattoos have become more popular, with nearly one-third of U.S. adults sporting at least one tattoo, religious-themed tattoos have also increased. A recent study examined the behaviors of college students with tattoos, including religious tattoos.
Jerome R. Koch, Ph.D., professor of sociology at Texas Tech University, and Kevin D. Dougherty, Ph.D., professor of sociology at ...
2023-05-16
An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues. The finding may offer a new way to fight difficult-to-treat and potentially lethal infections.
Nourseothricin is a natural product made by a soil fungus, which contains multiple forms of a complex molecule called streptothricin. Its discovery in the 1940s generated high hopes ...
LAST 30 PRESS RELEASES:
[Press-News.org] Musashi 1 in breast cancer: Implications for dormancy and survival in bone marrow
