Genetic associations between modifiable risk factors and Alzheimer disease

JAMA Network Open

2023-05-17

(Press-News.org) About The Study: This genetic association study including 39,000 participants with clinically diagnosed Alzheimer disease (AD) and 401,000 control participants without AD found novel genetic associations between high high-density lipoprotein (HDL) cholesterol concentrations and high systolic blood pressure with higher risk of AD. These findings may inspire new drug targeting and improved prevention implementation.

Authors: Ruth Frikke-Schmidt, M.D., D.M.Sc., Ph.D., of Copenhagen University Hospital–Rigshospitalet in Copenhagen, is the corresponding author.

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(doi:10.1001/jamanetworkopen.2023.13734)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Genetic associations between modifiable risk factors and Alzheimer disease

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