(Press-News.org) About The Study: This genetic association study including 39,000 participants with clinically diagnosed Alzheimer disease (AD) and 401,000 control participants without AD found novel genetic associations between high high-density lipoprotein (HDL) cholesterol concentrations and high systolic blood pressure with higher risk of AD. These findings may inspire new drug targeting and improved prevention implementation.
Authors: Ruth Frikke-Schmidt, M.D., D.M.Sc., Ph.D., of Copenhagen University Hospital–Rigshospitalet in Copenhagen, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2023.13734)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.13734?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=051723
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Genetic associations between modifiable risk factors and Alzheimer disease
JAMA Network Open
2023-05-17
ELSE PRESS RELEASES FROM THIS DATE:
Radio signal reveals supernova origin
2023-05-17
In the latest issue of the journal Nature, astronomers from Stockholm University reveal the origin of a thermonuclear supernova explosion. Strong emission lines of helium and the first detection of such a supernova in radio waves show that the exploding white dwarf star had a helium-rich companion.
Supernovae of Type Ia are important for astronomers since they are used to measure the expansion of the Universe. However, the origin of these explosions has remained an open question. While it is established that the explosion is that of a compact ...
Are Earth and Venus the only volcanic planets? Not anymore.
2023-05-17
Imagine an Earth-sized planet that’s not at all Earth-like. Half this world is locked in permanent daytime, the other half in permanent night, and it’s carpeted with active volcanoes. Astronomers have discovered that planet.
The planet, named LP 791-18d, orbits a small red dwarf star about 90 light years away. Volcanic activity makes the discovery particularly notable for astronomers because volcanism facilitates interaction between a world’s interior and its exterior.
“Why is volcanism important? It is the major source contributing to a planetary atmosphere, and with an atmosphere you could have surface liquid water — a requirement for sustaining ...
A channel involved in pain sensation can also suppress it
2023-05-17
Pain is good. It’s the body’s way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to tamp that response down under certain circumstances.
Researchers at UC Santa Barbara identified the pathway in fruit flies that reduces the sensation of pain from heat. Remarkably, just a single neuron on each side of the animal’s brain controls the response. What’s more, the molecule responsible for suppressing ...
Genetic research offers new perspective on the early evolution of animals
2023-05-17
A study published by MBARI researchers and their collaborators today in Nature provides new insights about one of the earliest points in animal evolution that happened more than 700 million years ago.
For more than a century, scientists have been working to understand the pivotal moment when an ancient organism gave rise to the diverse array of animals in the world today. As technology and science have advanced, scientists have investigated two alternative hypotheses for which animals—sponges or comb jellies, also known as ctenophores—were most distantly related to all other animals. Identifying this outlier—known as the sibling ...
Research spotlight: a conversational artificial intelligence program can generate credible medical information in response to common patient questions
2023-05-17
What was the question you set out to answer with this study?
ChatGPT, a new language processing tool driven by artificial intelligence (AI), provides conversational text responses to questions and can generate valuable information for enquiring individuals, but the quality of ChatGPT-generated answers to medical questions is currently unclear.
What Methods or Approach Did You Use?
We retrieved eight common questions and answers about colonoscopy from the publicly available webpages of three randomly-selected hospitals from the top-20 list of the US News & World Report Best Hospitals for Gastroenterology and Gastrointestinal Surgery.
We ...
How breast cancer arises
2023-05-17
In what may turn out to be a long-missing piece in the puzzle of breast cancer, Harvard Medical School researchers have identified the molecular sparkplug that ignites cases of the disease currently unexplained by the classical model of breast-cancer development.
A report on the team’s work is published May 17 in Nature.
“We have identified what we believe is the original molecular trigger that initiates a cascade culminating in breast tumor development in a subset of breast cancers that are driven by estrogen,” said study senior investigator Peter Park, professor of ...
Astronomers find potentially volcano-covered Earth-size world
2023-05-17
Cambridge, Mass. – Astronomers have discovered an Earth-size exoplanet, a world beyond the solar system, that may be carpeted with volcanoes and could potentially support life. Called LP 791-18 d, the planet could undergo volcanic outbursts as often as Jupiter’s moon Io, the most volcanically active body in the solar system.
The planet was first reported in Nature and the discovery was made possible in part due to ground-based observations made by the Center for Astrophysics | Harvard & Smithsonian.
LP 791-18 d orbits a small red dwarf star about 90 light-years away in a southern constellation called Crater. The ...
Vigorous exercise not tied to increased risk of adverse events in rare heart condition
2023-05-17
Vigorous exercise does not appear to increase the risk of death or life-threatening arrhythmia for people with hypertrophic cardiomyopathy (HCM), according to a study supported by the National Institutes of Health. HCM is a rare, inherited disorder that causes the heart muscle to become thick and enlarged and affects 1 in 500 people worldwide. It has been associated with sudden cardiac death in young athletes and other young people. However, the study, published in JAMA Cardiology, found that people with the disease who exercise vigorously are no more likely to die or experience severe cardiac events than those who exercised moderately ...
Climate change made record Asia humid heatwave at least 30 times more likely: attribution study
2023-05-17
Human-caused climate change made April’s record-breaking humid heatwave in Bangladesh, India, Laos and Thailand at least 30 times more likely, according to rapid attribution analysis by an international team of leading climate scientists as part of the World Weather Attribution group. The study also concludes that the high vulnerability in the region, which is one of the world’s heatwave hotpots, amplified the impacts.
In April, parts of south and southeast Asia experienced an intense heatwave, with record-breaking temperatures that passed 42ºC in Laos and 45°C in Thailand. The heat ...
Study finds link between deprived areas and number of children in care proceedings in England
2023-05-17
A strong link between the extent of deprivation of local authorities in England and their numbers of children going into the care system through the family courts has been uncovered by researchers at Lancaster University.
The study, available online and due to be published in July 2023 in the journal Children & Society, found that for every one unit increase in the standardized Office for National Statistics’ (ONS) English index of multiple area deprivation, the number of children in care proceedings in English family courts increased by around 70%.
The research team analysed data from the English Children and Family Court Advisory and Support Service ...
LAST 30 PRESS RELEASES:
New “bone-digesting” cell type discovered in pythons
New study points to Skagerrak as nursery area for the enigmatic Greenland shark
Are sewage spills and coastal winds contributing to airborne microplastics?
Which factors affect the success of popular prescription weight loss drugs in individuals?
Do renter protection policies reduce rental housing discrimination?
Does grading students at earlier ages increase the risk of mental disorders in adolescents?
New artificial intelligence–based test detects early signs of osteoporosis from X-ray images
Can eating a healthy plant-based diet help protect against inflammatory bowel disease?
Do local voting rights affect migrants’ participation in protests?
Mysterious ‘Dark Dwarfs’ may be hiding at the heart of the Milky Way
Real-world data shows teclistamab can benefit many multiple myeloma patients who would have been ineligible for pivotal trial
Scientists reveal how a key inflammatory molecule triggers esophageal muscle contraction
Duration of heat waves accelerating faster than global warming
New mathematical insights into Lagrangian turbulence
Clinical trials reveal promising alternatives to high-toxicity tuberculosis drug
Artificial solar eclipses in space could shed light on Sun
Probing the cosmic Dark Ages from the far side of the Moon
UK hopes to bolster space weather forecasts with Europe's first solar storm monitor
Can one video change a teen's mindset? New study says yes - but there’s a catch
How lakes connect to groundwater critical for resilience to climate change, research finds
Youngest basaltic lunar meteorite fills nearly one billion-year gap in Moon’s volcanic history
Cal Poly Chemistry professor among three U.S. faculty to be honored for contributions to chemistry instruction
Stoichiometric crystal shows promise in quantum memory
Study sheds light on why some prostate tumors are resistant to treatment
Tree pollen reveals 150,000 years of monsoon history—and a warning for Australia’s northern rainfall
Best skin care ingredients revealed in thorough, national review
MicroRNA is awarded an Impact Factor Ranking for 2024
From COVID to cancer, new at-home test spots disease with startling accuracy
Now accepting submissions: Special Collection on Cognitive Aging
Young adult literature is not as young as it used to be
[Press-News.org] Genetic associations between modifiable risk factors and Alzheimer diseaseJAMA Network Open