(Press-News.org) PHOENIX, AZ (May 19, 2023) – The latest analysis from The North American COVID-19 STEMI (NACMI) was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The findings show patients with an ST-elevated myocardial infarction, or STEMI, and COVID-19 had a significant amount of clotting in their arteries both before and after intervention. Importantly, clots were seen in multiple arteries in close to 30% of patients, a phenomenon observed in less than 5% of patients with heart attacks who do not have COVID-19.
In the United States, someone experiences a heart attack every 40 seconds (CDC). Of these patients, more than 25% will experience a more severe type of heart attack, an ST-elevated myocardial infarction, or STEMI caused by the sudden, total blockage of a coronary artery. Pre-COVID-19 mortality in STEMI patients was below 5% (JACC). Previous NACMI research has shown that mortality jumps to 20% to 25% in patients who present with COVID-19 and a heart attack.
In this blinded angiographic analysis, sites were invited to send angiograms to the Cardiovascular Imaging Research Core Lab (Vancouver, CA). Quantitative coronary angiography percent diameter stenosis (DS), thrombolysis in myocardial infarction (TIMI) flow, myocardial blush grade (MBG) and thrombus grade burden (TGB) were assessed. Percutaneous coronary intervention (PCI) was classified as unsuccessful if there was residual DS>50% and/or <TIMI 2 flow and/or untreated complication(s). Multi-vessel (MV) thrombotic disease and stenotic disease was defined as TGB > 0 and DS > 50% in > 2 arteries, respectively.
Angiograms of 234 patients from 17 sites (12 US, 5 CAN) were analyzed. High TGB was observed in 74% of all patients pre-intervention and 29% of patients post intervention. A high proportion of patients (19%) did not have culprit lesions (locations inside the arteries readily identified by treating physicians) suggesting other mechanisms for heart attack maybe at play in this patient population. Core lab identified stent thrombosis (clotting of previously placed stents) in 12% of the entire cohort – a frequency that has never been observed in other STEMI cohorts. Of the 49 patients Core lab identified PCI failure rates were 34% which a high complication rate of 23%, mostly related to thrombus.
“COVID-19 is a pro-inflammatory, clot forming disease and we now see its effect in the coronary arteries,” said Payam Dehghani, MD, FRCPC, FACC, FSCAI, Co-Director of Prairie Vascular Research Inc and Associate Professor at the University of Saskatchewan, Canada. “These new insights point to the need for clinicians to be meticulous with blood thinning strategies, early interventions and patient follow-up.”
The NACMI registry is a collaboration between SCAI, the American College of Cardiology and the Canadian Association of Interventional Cardiology. The registry was established in 2020 with the aim to define baseline characteristics and management strategies and outcome data for COVID-19 patients presenting with STEMI. More than 60 medical centers across North America and Canada contributed data to the registry.
Researchers note that further investigation is needed to better understand the impact of COVID-19 and heart attacks related vaccination as well as long-term outcomes.
Sessions Details:
“Core-laboratory Angiographic Characteristics and Mortality of Patients with STEMI and COVID-19: Insights from the NACMI Registry.” [May 19, 2023, 3:40 – 5:10 p.m. MST, West 103, First Floor, Phoenix Convention Center]
About SCAI:
The Society for Cardiovascular Angiography & Interventions (SCAI) is a non-profit professional association with over 4,500 members representing interventional cardiologists and cardiac catheterization teams in the United States. SCAI promotes excellence in interventional cardiovascular medicine for both adults and children through education, representation, and the advancement of quality standards to enhance patient care.
For more information about the SCAI 2023 Scientific Sessions, visit https://scai.org/scai-2023-scientific-sessions. Follow @SCAI on Twitter for the latest heart health news and use #SCAI2023 to follow the latest discussions.
# # #
END
The course of human history has been marked by complex patterns of migration, isolation, and admixture, the latter a term that refers to gene flow between individuals from different populations. Admixture results in a blending of genetic lineages, leading to increased genetic diversity within populations. In addition to admixture among modern human populations, ancient humans reproduced with other hominin groups, such as Neanderthals and Denisovans. This resulted in fragments of DNA from these ancient lineages being passed down to modern humans in a process known as introgression. Two ...
WASHINGTON, May 19, 2023 — Chemical & Engineering News (C&EN), an independent news outlet of the American Chemical Society (ACS), has unveiled its annual “Talented 12” list. The list highlights early-career researchers in the chemical sciences who are fearlessly tackling difficult global problems. These intrepid innovators in chemistry are featured in the May 19 issue of C&EN; read about the impressive class by visiting https://cenm.ag/t12-2023.
Using a rigorous review process, C&EN selected this year’s Talented 12 from a highly competitive pool. The world-changing work by this year’s group includes research with ...
HOUSTON – (May 19, 2023) – Rice University chemist Raúl Hernández Sánchez is one of 12 early-career scientists named to C&EN’s 2023 Talented 12 cohort for his research in inorganic and supramolecular chemistry.
Awardees are scientists engaged in world-changing work who are at an early stage in their career – pre-tenure if working in academia and 10 years or less from the completion of their postdoctoral studies if working in industry or government. The members of this year’s C&EN ...
BOSTON – The Bacillus Calmette-Guérin (BCG) vaccine—which prevents tuberculosis—offers multiple beneficial effects, and it’s currently a recommended therapy for non–muscle-invasive bladder cancer. In a new study led by investigators at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH), treatment with the BCG vaccine was associated with a reduced risk of Alzheimer’s disease and related dementias. The findings are published in JAMA Network Open.
Although previous research has suggested a link between the BCG vaccine and a lower risk of dementia, studies were limited by size, study design, ...
Reforms to New Jersey’s Medicaid program successfully spurred ongoing increases in buprenorphine prescriptions for the treatment of opioid addiction, according to a Rutgers analysis.
Although medications such as buprenorphine effectively combat opioid addiction, less than 30 percent of potential users receive them nationwide. New Jersey sought to increase prescription numbers with three Medicaid reforms that took effect in 2019. The reforms:
Removed prior authorization requirements for buprenorphine prescriptions
Increased reimbursement rates for in-office opioid addiction treatment
Established regional centers of excellence for addiction ...
Phoenix, AZ (May 19, 2023)- Six month outcomes from the FlowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH) registry were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The prospective multi-center study found that patients with pulmonary embolism (PE) who were treated with mechanical thrombectomy showed significant improvement in symptoms, quality of life and cardiac functions.
Pulmonary embolism, a blood clot that starts in a blood vessel in the body and travels to ...
Phoenix, AZ (May 19, 2023)- New analysis of chronic limb-threatening ischemia (CLTI) treatment outcomes was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. Following the initial results of the BEST-CLI (Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia) trial in 2022 which found surgical intervention superior to endovascular revascularization, questions remained regarding how inclusive the enrolled patient population was, how reflective the specialty of the physicians who performed the procedures are compared to the broader ...
Phoenix, AZ (May 19, 2023)- Data from a cohort of one million patients with chronic limb-threatening ischemia (CLTI) were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. Using data from Medicare, the cohort, Chronic Limb threatening Ischemia Process PERformance (CLIPPER), found one out of six patients with CLTI died within their first year of diagnosis and 50% survived at five years.
CLTI is a serious condition in ...
Phoenix, AZ (May 19, 2023)- Results from the Evolut FX TAVR (Transcatheter Aortic Valve Replacement) Clinical Survey were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The survey, comprised of feedback from physicians across the United States, reported improved deliverability, tracking, and deployment of the next-generation device compared to its predecessor.
Aortic stenosis (AS), is one of the most common valvular heart diseases and can potentially lead to heart failure. Once symptoms of AS begin, average ...
Phoenix, AZ (May 19, 2023)- A new study examining the criteria proposed by the European Society of Cardiology (ESC) to prescribe long-term treatment with more than one blood thinner after percutaneous coronary intervention was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions. The study confirmed that patients presenting the characteristics proposed in the ESC guidelines are more likely to experience complications due to blood clotting in the coronary arteries. These patients may therefore benefit from a long-term treatment with more ...
