- Press Release Distribution

COPDGene study follows emphysema patients over 10 years

Disease progresses faster in those that continue to smoke after diagnosis

( Researchers at National Jewish Health evaluating computerized tomography (CT) scans of emphysema progression in the COPDGene® study showed that, during a span of 10 years, participants with pre-existing emphysema who continued smoking had the largest decline in adjusted lung density (ALD). The lung density decline was notably worse in current smokers compared with former smokers. The study is significant because reliably measuring changes in emphysema over time has always been challenging, due in part to differences in CT equipment technology and imaging parameters across institutions. The study, which published in April in the journal Radiology, accounts for many of the sources of variability.

Chronic obstructive pulmonary disease (COPD) affects an estimated 5% of the population and is the fourth most common cause of death in the United States. COPDGene is one of the largest studies ever to investigate the underlying genetic factors of COPD. With the use of CT scans, COPDGene has been seeking to better classify COPD and increase understanding of how the disease may differ from person to person. Emphysema is one of the diseases that comprises COPD.

“Using CT, we were able to show that emphysema progresses significantly faster in patients with existing emphysema and who continue to smoke,” said David Lynch, MB, radiologist and senior author on the research. “This is also impactful in that we were able to use CT scans to identify the progression of emphysema over time, while adjusting for multiple sources of variation.”

Between 2008 and 2011, over 10,000 cigarette smokers with and without COPD were enrolled in the study at 21 centers across the U.S. Participants underwent baseline evaluation and returned for a 5-year and 10-year follow-up. Emphysema progression was modeled using ALD based on quantitative CT. Emphysema progression was greatest in current smokers who had more than trace emphysema at the beginning baseline.

“Among patients with pre-existing emphysema, the difference in the rate of emphysema progression between current and former smokers shows the need for smoking cessation,” said David Baraghoshi, MSTAT, research assistant in the Division of Biostatistics and Bioinformatics at National Jewish Health, and first author on the research.

National Jewish Health is the leading respiratory hospital in the nation. Founded 124 years ago as a nonprofit hospital, National Jewish Health today is the only facility in the world dedicated exclusively to groundbreaking medical research and treatment of patients with respiratory, cardiac, immune and related disorders. Patients and families come to National Jewish Health from around the world to receive cutting-edge, comprehensive, coordinated care. To learn more, visit the media resources page.



Trial aims to improve treatment for newborns with life-threatening sepsis

Trial aims to improve treatment for newborns with life-threatening sepsis
An international clinical trial co-led by UCL (University College London) researchers will evaluate much-needed new antibiotic combinations for newborn babies with sepsis. The trial, which has started in three public hospitals in South Africa and Kenya, will be expanded to other countries and regions in 2024, with a target of recruiting up to 3,000 newborns overall. The NeoSep1 trial will evaluate new combinations of generic antibiotics and compare them to existing treatment regimens that are often used in newborn babies with suspected neonatal sepsis. Chris Hani Baragwanath Academic Hospital in Johannesburg, Tygerberg ...

Previous smallpox vaccine provides immunity to mpox

Vaccines against smallpox given until the mid-1970s offer continuing cross-reactive immunity to mpox (previously known as monkeypox), researchers from Karolinska Institutet in Sweden report in a study published in the scientific journal Cell Host & Microbe. During last year’s mpox outbreak, the virus spread for the first time outside Africa, causing over 85,000 cases of the disease to date. Men who have sex with men account for the most infections, with a marked skew towards the young. The virus that causes mpox is what is known as an orthopoxvirus and is very similar to the virus that caused ...

Fever found to be most common non-respiratory feature of SARS-CoV-2 infection

Fever found to be most common non-respiratory feature of SARS-CoV-2 infection
Session:  C58, Health Services Research in Diverse Settings Date and Time: 11:30 a.m. ET, Tuesday, May 23, 2023 Location:  WEWCC, Area 1, Hall C (Lower Level)   ATS 2023, Washington, DC – Fever was found to be the most common non-respiratory feature of infection with SARS-CoV-2, the virus that causes COVID-19, according to research published at the ATS 2023 International Conference.  The finding held true regardless of which COVID variant patients had, and whether or not they were fully vaccinated or not fully vaccinated. The researchers, who also looked at mortality risk, found that patients who were ...

International group of experts redefines concussions

Doctors and other health-care providers have a new standard for diagnosing mild traumatic brain injury (TBI), thanks to a thorough process led by researchers from the University of B.C. and Harvard-affiliated Spaulding Rehabilitation Hospital. "We've achieved consensus across a diverse range of experts in developing these new diagnostic criteria,” said Dr. Noah Silverberg, associate professor in UBC’s department of psychology, member of the Djavad Mowafaghian Centre for Brain Health and Centre for Aging SMART at Vancouver Coastal Health, and co-lead of the project. “Our ...

USC Health System Board appoints Paul B. Rothman, MD, as board member

USC Health System Board appoints Paul B. Rothman, MD, as board member
LOS ANGELES — Paul B. Rothman, MD, has been appointed as a member of the USC Health System Board, which provides strategic oversight and governance over Keck Medicine of USC and university clinical services.  Rothman, former CEO of Johns Hopkins Medicine and retired dean of medical faculty for the Johns Hopkins University School of Medicine, brings his leadership acumen as well as clinical and scientific expertise in rheumatology and molecular immunology to this advisory role.  “Paul ...

Diagnosis of type 1 diabetes after SARS-CoV-2 infection: Researchers find possible correlation

Different studies have documented an increased incidence of type 1 diabetes during the COVID-19 pandemic. However, none of the studies distinguishes between children with and without SARS-CoV-2 infection. Researchers were now able to gain new insights: the KVB data set provides information on whether children diagnosed with type 1 diabetes previously had COVID-19. This allows an analysis of the temporal relationship between a COVID-19 diagnosis and the diagnosis of type 1 diabetes. Amongst the analyzed children without ...

RPI and Albany Medical College researchers awarded $3.3 million to improve breast cancer treatment using artificial intelligence

RPI and Albany Medical College researchers awarded $3.3 million to improve breast cancer treatment using artificial intelligence
Researchers from Rensselaer Polytechnic Institute (RPI) and Albany Medical College were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence (AI) to improve targeted drug therapy in HER2-positive breast cancer treatment. HER2-positive breast cancer tends to grow and spread quickly, but targeted treatments improve outcomes. The research is being led by Xavier Intes, Rensselaer professor of biomedical engineering and co-director of the Center for Modeling, Simulation and Imaging in Medicine, and ...

Element creation in the lab deepens understanding of surface explosions on neutron stars

Element creation in the lab deepens understanding of surface explosions on neutron stars
Led by Kelly Chipps of the Department of Energy’s Oak Ridge National Laboratory, scientists working in the lab have produced a signature nuclear reaction that occurs on the surface of a neutron star gobbling mass from a companion star. Their achievement improves understanding of stellar processes generating diverse nuclear isotopes. “Neutron stars are really fascinating from the points of view of both nuclear physics and astrophysics,” said ORNL nuclear astrophysicist Kelly Chipps, who led a study published in Physical Review Letters. “A deeper understanding of their dynamics may help reveal the cosmic ...

New treatment helps people stop addictive opioid painkillers used for chronic pain

Programme of combined one-to-one and group support sessions was tested in landmark clinical trial After one year, one in five people were able to stop taking opioids without their pain increasing Experts say the new treatment is an alternative to opioid use and has potential to give patients better quality of life Researchers at the University of Warwick and The James Cook University Hospital, Middlesbrough have led a clinical trial, funded by the National Institute for Health and Care Research (NIHR), on a new treatment which can help people stop needing to use opioid painkillers to manage chronic pain. There are over 1 ...

CT scan best at predicting heart disease risk in middle age

CHICAGO ---CT scans are better at predicting a middle-aged person’s risk for a heart disease, such as a heart attack, than genetics, reports a new Northwestern Medicine study.  “Finding the best way to identify who is at risk for developing heart disease can help determine what needs to be done to lower their risk,” said lead study author Dr. Sadiya Khan, an assistant professor of medicine and preventive medicine at Northwestern University Feinberg School of Medicine and a Northwestern Medicine cardiologist. “This finding can help doctors and patients in managing risk for heart disease, which is the leading cause ...


Generative AI tools like Pix2Pix–BicycleGAN are revolutionizing landscape design by enhancing masterplan generation and rendering

Expanding APAC presence, Insilico Medicine seals strategic collaboration on AI-driven mash therapy development with Korean Biotech Therasid Bioscience

When it comes to butterflies, people prefer pretty ones. That’s a problem for scientists.

UBC Okanagan study raises concerns about partner violence in queer relationships

Human-infecting parasite produces sterile soldiers like ants and termites

The unintended consequences of success against malaria

Taco-shaped arthropod from Royal Ontario Museum’s Burgess Shale fossils gives new insights into the history of the first mandibulates

Butterflies accumulate enough static electricity to attract pollen without contact, new research finds

Eyes for Love: Searching for light and a mate in the deep, dark sea, male dragonfishes grow larger eyes than the females they seek

PNNL scientists tap nation’s fastest computers to explore critical science questions

Peri-operative care of transgender and gender-diverse individuals: new guidance for clinicians and departments published

Clinical psychologist’s book addresses largely ignored problem: social anxiety

Researchers leveraging AI to train (robotic) dogs to respond to their masters

Drawing water from dry air

Combining trapped atoms and photonics for new quantum devices

A new way to make element 116 opens the door to heavier atoms

New genetic tool could identify drug targets for diseases associated with metabolic dysfunction

Plant Biologist Siobhan Brady named HHMI Investigator

Long-acting injectable cabotegravir for HIV prevention is safe in pregnancy

Large language models don’t behave like people, even though we may expect them to

NREL researchers highlight opportunities for manufacturing perovskite solar panels with a long-term vision

Top Medicare advantage plans less available in disadvantaged areas

Better carbon storage better carbon storage with stacked geology with stacked geology

Sharp temperature reduction for quantum dots in polymer by highly efficient heat dissipation pathways

UAF researcher creates way to detect elusive volcanic vibrations

Lissajous pattern multi-pass cell: Enhancing high sensitivity and simultaneous dual-gas LITES sensing

Asexual reproduction usually leads to a lack of genetic diversity. Not for these ants.

Mini lungs make major COVID-19 discoveries possible

Exploratory analysis associates HIV drug abacavir with elevated cardiovascular disease risk in large global trial

Control of light–matter interactions in two-dimensional materials with nanoparticle-on-mirror structures

[] COPDGene study follows emphysema patients over 10 years
Disease progresses faster in those that continue to smoke after diagnosis