“In this study, we present novel transcriptional dependencies between MALAT1 and MAPK-pathway-associated genes in melanoma.”
BUFFALO, NY- May 30, 2023 – A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, “Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment.”
The long non-coding RNA (lncRNA) MALAT1 is a regulator of oncogenesis and cancer progression. MAPK-pathway upregulation is the main event in the development and progression of human cancer, including melanoma and recent studies have shown that MALAT1 has a significant impact on the regulation of gene and protein expression in the MAPK pathway. However, the role of MALAT1 in regulation of gene and protein expression of the MAPK-pathway kinases RAS, RAF, MEK, and ERK in melanoma is largely unknown.
In this study, researchers Valentin Feichtenschlager, Yixuan James Zheng, Wilson Ho, Linan Chen, Ciara Callanan, Christopher Chen, Albert Lee, Jose Ortiz, Klemens Rappersberger, and Susana Ortiz-Urda from the University of California San Francisco and Medical University Vienna demonstrated the impacts of antisense oligonucleotide (ASO)-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma.
“Our results showed that MALAT1-ASO treatment decreased BRAF RNA expression and protein levels, and MALAT1 had increased correlation with MAPK-pathway associated genes in melanoma patient samples compared to healthy skin.”
Additionally, drug-induced MAPK inhibition upregulated MALAT1-expression, a finding that resonates with a paradigm of MALAT1-expression presented in this work: MALAT1 is downregulated in melanoma and other cancer types in which MALAT1 seems to be associated with MAPK-signaling, while MALAT1-ASO treatment strongly reduced the growth of melanoma cell lines, even in cases of resistance to MEK inhibition. MALAT1-ASO treatment significantly inhibited colony formation in vitro and reduced tumor growth in an NRAS-mutant melanoma xenograft mouse model in vivo, while showing no aberrant toxic side effects.
“Our findings demonstrate new insights into MALAT1-mediated MAPK-pathway gene regulation and a paradigm of MALAT1 expression in MAPK-signaling-dependent cancer types. MALAT1 maintains essential oncogenic functions, despite being downregulated.”
Read the full paper: DOI: https://doi.org/10.18632/oncotarget.28447
Correspondence to: Valentin Feichtenschlager
Keywords: MALAT1, MAPK-pathway, BRAF, melanoma, antisense oligonucleotides
About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact: firstname.lastname@example.org.
Oncotarget Journal Office
6666 East Quaker Str., Suite 1A
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
The low blood oxygen levels of obstructive sleep apnea cause widespread changes in gene activity throughout the day, according to a new study in the open-access journal PLOS Biology by David Smith of Cincinnati Children’s Hospital Medical Center, US, and colleagues. The finding may lead to tools for earlier diagnosis and tracking of the disorder.
Obstructive sleep apnea (OSA) occurs when the airway becomes blocked (usually by soft tissue, associated with snoring and interrupted breathing during the night), resulting in intermittent hypoxia (low blood oxygen) and disrupted sleep. ...
Since it was identified in 1984 as the cause of Acquired Immune Deficiency Syndrome (AIDS), the human immunodeficiency virus (HIV) has infected more than 80 million people and been responsible for some 40 million deaths worldwide, according to the World Health Organization (WHO). Currently, the WHO reports more than 38 million people globally live with the retrovirus, and each year, another 1 million new cases are diagnosed. While antiretroviral therapy helps keep HIV in check, patients must stay on their medication to prevent the development of AIDS.
Scientists have spent years trying to develop an ...
INDIANAPOLIS—Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person’s risk of alcohol use disorder (AUD). They recently published their findings in Molecular Psychiatry.
“AUD is a common and complex genetic disorder that happens people experience problems related to excessive alcohol consumption,” said Rudong Li, PhD, a postdoctoral fellow in the YunLong Liu, PhD Laboratory and lead author of the paper. “This discovery has revealed ...
FOR IMMEDIATE RELEASE, May 30, 2023
Contact: Gina DiGravio, 617-358-7838, email@example.com
Novel Approach Significantly Improves Access, Decreases Wait Times for Autism Screening
Developmentally Trained-Primary Care Clinicians can reduce disparities for children referred for developmental evaluation
(Boston)—Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and the presence of repetitive and restricted behaviors or interests. The American Academy of Pediatrics (AAP) recommends autism-specific screening at 18- and 24-month well-child visits, yet earlier diagnosis has been shown to ...
CHAMPAIGN, Ill. — Before it was home to Spain and Portugal, much of the Iberian Peninsula was ruled by a succession of Islamic dynasties for almost 800 years during the Middle Ages. Known as al-Andalus, its influence is still reflected in art and politics today – not only in Spain and North Africa, but also in places far from the historical site of al-Andalus.
Eric Calderwood, a comparative and world literature professor at the University of Illinois Urbana-Champaign, wrote about that influence and how it is used to make sense of the present in his new book, “On Earth or in Poems: ...
A team of astrophysicists and citizen scientists have identified what may be some of the last planets NASA’s retired Kepler space telescope observed during its nearly decade-long mission.
The trio of exoplanets – worlds beyond our solar system – are all between the size of Earth and Neptune and closely orbit their stars.
''These are fairly average planets in the grand scheme of Kepler observations,” said Elyse Incha, a senior at the University of Wisconsin-Madison. “But they’re exciting because Kepler observed them during its last few days of operations. It showcases just how good Kepler was at planet hunting, even at the end of its ...
The Shaw Prize in Astronomy 2023 is awarded in equal shares to Matthew Bailes, Director of the Australian Research Council (ARC) Centre of Excellence for Gravitational Wave Discovery, Duncan Lorimer, Professor and Interim Chair of Physics and Astronomy and Associate Dean for Research at Eberly College of Arts and Sciences at West Virginia University, USA and Maura McLaughlin, Eberly Family Distinguished Professor at the Department of Physics and Astronomy, West Virginia University, USA, for the discovery ...
Worldwide, one of the initial responses to the COVID-19 virus was locking down parts of the economy to reduce social interactions and the virus’s spread. Now, the development and production of vaccines have largely replaced broad lockdowns. In a new study that considered epidemiology and economics, researchers sought to determine how the arrival of vaccines should affect the duration and intensity of lockdown policies. They concluded that boosting the rate of vaccine use influences intensity and duration of lockdowns, depending on a variety of factors.
The study was conducted by researchers at Carnegie Mellon University (CMU), the International Institute for Applied Systems Analysis, ...
Health care organizations today are caring for patients with increasingly complex needs and leveraging larger teams that include clinicians with diverse and specialized expertise. At the same time, high turnover and labor shortages mean that facilities frequently employ a more temporary and mobile workforce. In a new commentary, researchers point out that, as a result, “the structure of health care teams often defies decades of wisdom from team-design research about the conditions that support the best possible performance.”
The article was written ...
30 May 2023 - A detailed plan to transform product packaging and significantly cut plastic production and pollution has been developed by researchers.
The study comes as government representatives meet in Paris to negotiate a legally binding global plastics treaty with a mandate to end plastic pollution.
The research, published today by the University of Portsmouth’s Global Plastics Policy Centre, commissioned by the Break Free From Plastic movement, consolidates 320 articles and papers, plus 55 new interviews with reuse experts from around the world , to suggest a universal definition of reuse systems and, for the ...