(Press-News.org) June 21, 2023 – A second-generation "all-inside" meniscal repair system provides a high success rate at long-term follow-up, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
"Our 10-year results of second-generation, all-inside repair were better than those of first-generation implants and equivalent to those seen with the other common techniques," according to the new research, led by Rick W. Wright, MD, of Vanderbilt University Medical Center, Nashville.
Long-term follow-up after meniscal repair using FasT-Fix system
For patients with meniscal tears in the knee joint, treatment focuses on repairing and preserving the damaged meniscus whenever possible. All-inside meniscal repair techniques were developed as an alternative to previous arthroscopic "inside-out" techniques.
Subsequent second-generation all-inside repair devices brought further advances, quickly becoming the most common approach to meniscal repair. Previous reports suggest similar five-year outcomes with inside-out and current all-inside techniques, with failure rates of 14.2% and 15.8%, respectively.
However, few studies have presented 10-year follow-up data on the outcomes of second-generation all-inside techniques. "We hypothesized that all-inside repairs that have demonstrated good results at five years would maintain their reasonable outcomes beyond 10 years and remain equally successful compared with inside-out repairs," Dr. Wright and colleagues write.
The researchers analyzed the long-term outcomes of patients undergoing meniscal repair using the second-generation FasT-Fix system from 2002 through 2008. All patients underwent primary repair of a torn meniscus in conjunction with anterior cruciate ligament (ACL) reconstruction.
Of 81 treated patients, 69 were available for follow-up at 10 years postoperatively, including 40 male and 29 female patients with an average age of 26.5 years. The medial meniscus was repaired in 73% of patients and the lateral meniscus in 27%. The main outcome of interest was the successful repair rate, defined as not undergoing subsequent surgery related to the meniscus during follow-up.
10-year success rates of 84% to 88%
By this definition, the failure rate was 13% overall, with 12% for medial and 16% for lateral meniscal repairs. The average time to failure was 2.8 years for the medial repairs and 5.8 years for the lateral repairs . Risk of failure was unrelated to patient characteristics (i.e., age, sex, or body mass index) or surgical characteristics (i.e., graft type or number of sutures).
Patient-reported outcomes were better after meniscal repair and ACL reconstruction, as compared with preoperative baseline measurements. Both at the time of surgery and at long-term follow-up, these outcomes were similar for patients with successful versus failed repairs. Activity level was significantly lower at 10-year follow-up, consistent with previously reported age-related decreases.
The study provides new evidence that all-inside meniscal repair using the second-generation FasT-Fix system with concomitant ACL reconstruction, "is a reasonable approach with good long-term results." Dr. Wright and coauthors write, "In our series, 84% to 88% of the patients had continued success at a minimum of 10 years after the repair."
For reasons that are unclear, treatment failure seemed to occur earlier following medial compared with lateral meniscal repair. The researchers emphasize the need for "long-term follow-up...to adequately assess meniscal repair."
Read [Ten-Year Outcomes of Second-Generation, All-Inside Meniscal Repair in the Setting of ACL Reconstruction]
Wolters Kluwer provides trusted clinical technology and evidence-based solutions that engage clinicians, patients, researchers and students in effective decision-making and outcomes across healthcare. We support clinical effectiveness, learning and research, clinical surveillance and compliance, as well as data solutions. For more information about our solutions, visit https://www.wolterskluwer.com/en/health and follow us on LinkedIn and Twitter @WKHealth.
###
About The Journal of Bone & Joint Surgery
The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.
About Wolters Kluwer
Wolters Kluwer (EURONEXT: WKL) is a global leader in professional information, software solutions, and services for the healthcare, tax and accounting, financial and corporate compliance, legal and regulatory, and corporate performance and ESG sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services.
Wolters Kluwer reported 2022 annual revenues of €5.5 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 20,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.
For more information, visit www.wolterskluwer.com, follow us on LinkedIn, Twitter, Facebook, and YouTube.
END
Toronto – Anita M. McGahan, a professor at the University of Toronto’s Rotman School of Management, is the 2023 recipient of the Sumantra Ghoshal Award for Rigour and Relevance in the Study of Management.
The Ghoshal Award recognizes a scholar who has distinguished themself by demonstrating both rigorous and impactful scholarship, and by engaging with the world of practice. The award is presented annually in the memory of Ghoshal, who was a professor at London Business School and whose research focused on ...
June 21, 2023 – For patients undergoing surgery for elbow trauma, treatment with the hemostatic drug tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO) – a common complication of abnormal bone formation, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
The findings "add new clinical evidence regarding the protective role of TXA with respect to the prevention of HO after elbow trauma," according to the report by Cunyi ...
Early warning signs of diseases caused by dysfunctional levels of stress hormones could be spotted more easily thanks to a new wearable device developed by endocrine researchers.
This is the first time it has been possible to measure changes to people’s stress hormones as they go about normal daily activities, across both day and night. The new collaborative research led by the University of Bristol, University of Birmingham and University of Bergen has the potential to revolutionise how diseases of the stress hormone system are diagnosed and treated.
The technology, ...
If you’ve ever wondered how the monarch butterfly got its spots, University of Georgia researchers may have just found the answer.
The new study suggests that the butterflies with more white spots are more successful at reaching their long-distance wintering destination. Although it’s not yet clear how the spots aid the species’ migration, it’s possible that the spots change airflow patterns around their wings.
“We undertook this project to learn how such a small animal can make such a successful ...
A new analysis suggests that wild, stray, and feral cats living in areas with higher human population density tend to release—or “shed”—a greater amount of the parasite that causes the disease toxoplasmosis. The study also draws links between environmental temperature variation and parasite shedding. Sophie Zhu of the University of California Davis, U.S., and colleagues present these findings in the open-access journal PLOS ONE on June 21.
Toxoplasmosis is a mild-to-severe disease caused by Toxoplasma gondii, which can infect warm-blooded vertebrates, including humans and many wild or domestic animals; for instance, cats, sheep, mice, birds, ...
The capability to reflect on their own mental state and that of others continues to develop throughout adolescence, with mentalizing scores varying by gender and personality traits, according to a new study published this week in the open-access journal PLOS ONE by Alex Desatnik of University College London, UK, and colleagues.
It has been established that the human brain undergoes a number of important changes during adolescence, especially in the “social brain” regions associated with social cognition. One of the key constructs capturing multiple facets of social cognition is ...
###
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0286921
Article Title: How the monarch got its spots: Long-distance migration selects for larger white spots on monarch butterfly wings
Author Countries: USA
Funding: The authors received no specific funding for this work. END ...
Approximately one in ten NHS healthcare workers experienced suicidal thoughts during the first year of the COVID-19 pandemic, finds a new University of Bristol-led study published in PLOS ONE today [21 June].
Concerns were raised about the risk of suicide among healthcare workers during the pandemic after a number of high-profile cases were reported in the media. Researchers from the University of Bristol, King’s College London and UCL (University College London), sought to investigate the prevalence and incidence of suicidal thoughts and behaviour among NHS healthcare workers in England and their relationship with occupational ...
Ruxolitinib, a drug that is already approved by the U.S. Food and Drug Administration (FDA) for treating certain cancers and skin conditions, is effective at inhibiting CaMKII, a protein kinase linked to cardiac arrhythmias.
In a new study published June 21, 2023, in Science Translational Medicine, researchers from Johns Hopkins University and the University of Chicago invented a new reporting technique to monitor activity of CaMKII while screening the effects of nearly 5,000 FDA approved drugs on human cells that expressed the ...
New global research on child mortality rates in Ethiopia shows while there has been a significant decline in these rates in past three decades, too many children under the age of five are still dying.
The analysis found the mortality rate in the under-five demographic decreased by almost 4.5 per cent every year between 1990 and 2019.
However, despite the progress, it’s still one of the highest rates in the world with an estimated 190,000 under 5 deaths in 2019 at the rate of 52 deaths per 1000 livebirths. The country’s neonatal mortality rate is 26.6 deaths per 1000 livebirths.
Lead author Dr Gizachew Tessema from the Curtin School of Population ...