Potential targets to delay motor aging revealed by C. elegans genome-wide screen

Genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34; genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice.

#####

In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002165

Article Title: Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span

Author Countries: China

Funding: see manuscript

Competing interests: The authors have declared that no competing interests exist.

END