PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

SGLT2 inhibitors and kidney outcomes by glomerular filtration rate and albuminuria

JAMA

2025-11-08
(Press-News.org) About The Study: The findings of this study support the routine use of sodium-glucose cotransporter 2 (SGLT2) inhibitors to improve kidney outcomes across the full spectrum of kidney function and albuminuria among patients with type 2 diabetes, chronic kidney disease, or heart failure. 

Corresponding Authors: To contact the corresponding authors, email Brendon L. Neuen, PhD (bneuen@georgeinstitute.org.au) and Hiddo J. L. Heerspink, PhD (h.j.lambers.heerspink@umcg.nl).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.20834)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

Media advisory: This study is being presented at the American Society of Nephrology Kidney Week 2025 meeting.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.20834?guestAccessKey=5cb973ba-2a15-4b6d-8e39-05dff6b0a313&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=110725

END


ELSE PRESS RELEASES FROM THIS DATE:

Comprehensive analysis supports routine use of metabolic drug for people with all levels of kidney function

2025-11-08
In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials.  The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists’ Consortium (SMART-C), led by The George Institute for Global Health. SGLT2 inhibitors, originally developed to treat type 2 diabetes, have since demonstrated substantial protection against heart failure and chronic ...

Temporary benefit for immune system in early HIV treatment, but dysregulation returns

2025-11-08
Despite effective HIV medication, the immune system of people with HIV remains disrupted in the long term. Researchers at Amsterdam UMC investigated whether this dysregulation can be prevented by starting HIV medication immediately after infection – i.e. within a few days. They saw that six months after this early treatment, the immune system did indeed work as in people without HIV. But in the longer term, the immune system was disrupted again. This is shown by research by Amsterdam UMC, published in the journal EBioMedicine. Early treatment protects immune systems only temporarily For this study, the scientists examined ...

Chronic kidney disease is now the ninth leading cause of death

2025-11-08
Record numbers of men and women globally are now estimated to have reduced kidney function, a new study shows. Figures rose from 378 million people with the disease in 1990 to 788 million in 2023 as the world population grew and aged, making it for the first time a top 10 cause of death worldwide.   Led by researchers at NYU Langone Health, the University of Glasgow, and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington, the analysis explored the rise of the illness, in which the kidneys gradually lose their ability to filter waste and excess fluid from the blood. Mild cases may have no symptoms while the most severe stages ...

Chronic kidney disease has more than doubled since 1990, now affecting nearly 800 million people worldwide

2025-11-08
In 2023, chronic kidney disease (CKD) was the 9th-leading cause of death worldwide, responsible for nearly 1.5 million deaths. Unlike most other leading causes of death, CKD mortality rates continue to rise, signaling a growing global health crisis.  In 2023, CKD ranked as the 12th-leading cause of disability worldwide and the 7th-leading driver of cardiovascular deaths. Kidney dysfunction alone accounted for almost 12% of all global cardiovascular deaths. Diabetes, obesity, and high blood pressure remain the top drivers of CKD, alongside dietary risks and environmental factors.  SEATTLE, Wash. – Nov. 7, ...

Participant experiences in a kidney failure care intervention in the navigate-kidney study

2025-11-08
About The Study: The results of this study suggest that community health workers played a vital role in improving patient engagement, emotional wellbeing, and self-efficacy, suggesting their integration into dialysis care teams may enhance holistic, patient-centered care.  Corresponding Author: To contact the corresponding author, Lilia Cervantes, MD, email Lilia.Cervantes@cuanschutz.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.48506) Editor’s ...

Community health worker support for Hispanic and Latino individuals receiving hemodialysis

2025-11-08
About The Study: In this randomized clinical trial, a culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence and patient activation among Hispanic and Latino patients with hemodialysis-dependent kidney failure.  Corresponding Author: To contact the corresponding author, Lilia Cervantes, MD, MSc, email lilia.cervantes@cuanschutz.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.5305) Editor’s Note: Please see the article for additional information, including other authors, author ...

Scientists unveil new strategies to balance farming and ecological protection in Northeast China

2025-11-07
As China’s most important grain-producing region, Northeast China plays a vital role in safeguarding national food security. Yet this agricultural powerhouse faces a growing dilemma: how to maintain high crop yields while protecting the fragile ecosystems that sustain long-term productivity. A new study published in Agricultural Ecology and Environment identifies the key conflicts between agricultural expansion and ecological protection in the region and proposes integrated strategies to achieve a more sustainable balance. Over the past four decades, Northeast China’s farmlands ...

UT Health San Antonio scientist helps shape new traumatic brain injury guidelines

2025-11-07
SAN ANTONIO, Nov. 7, 2025 – Traumatic brain injury, or TBI, affects millions of Americans each year, often resulting in long-term health challenges. New national recommendations are now paving the way for more effective short- and long-term care for patients with TBI. Monica Verduzco-Gutierrez, MD, a physiatrist with UT Health San Antonio, the academic health center of The University of Texas at San Antonio, and professor and chair of the Department of Physical Medicine and Rehabilitation at UT San Antonio’s Long School of Medicine, served on the National Academies of Sciences, ...

Rising nitrogen and rainfall could supercharge greenhouse gas emissions from the world’s largest grasslands

2025-11-07
As the planet warms and rainfall patterns shift, new research suggests that the world’s largest grassland region may become a growing source of nitrous oxide, a greenhouse gas nearly 300 times more potent than carbon dioxide. A team of scientists led by Dr. Shuping Qin from the Chinese Academy of Sciences examined how soil and climate conditions control the process of denitrification, a key microbial pathway that converts nitrogen compounds in soil into gases including nitrous oxide (N₂O) and nitrogen gas (N₂). Their study, recently published in Environmental and Biogeochemical Processes, is the first to map how denitrification responds ...

Study uncovers glomerular disease outcomes across the lifespan

2025-11-07
Houston, TX (November 7, 2025) — New research reveals that contrary toconventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients. The findings will be presented at ASN Kidney Week 2025 November 5–9. Direct comparisons of outcomes between adult and pediatric patients with primary glomerular diseases are rare—including minimal change disease (MCD), focalsegmental ...

LAST 30 PRESS RELEASES:

Researchers highlight role of alternative RNA splicing in schizophrenia

NTU Singapore scientists find new way to disarm antibiotic-resistant bacteria and restore healing in chronic wounds

Research suggests nationwide racial bias in media reporting on gun violence

Revealing the cell’s nanocourier at work

Health impacts of nursing home staffing

Public views about opioid overdose and people with opioid use disorder

Age-related changes in sperm DNA may play a role in autism risk

Ambitious model fails to explain near-death experiences, experts say

Multifaceted effects of inward foreign direct investment on new venture creation

Exploring mutations that spontaneously switch on a key brain cell receptor

Two-step genome editing enables the creation of full-length humanized mouse models

Pusan National University researchers develop light-activated tissue adhesive patch for rapid, watertight neurosurgical sealing

Study finds so-called super agers tend to have at least two key genetic advantages

Brain stimulation device cleared for ADHD in the US is overall safe but ineffective

Scientists discover natural ‘brake’ that could stop harmful inflammation

Tougher solid electrolyte advances long-sought lithium metal batteries

Experts provide policy roadmap to reduce dementia risk

New 3D imaging system could address limitations of MRI, CT and ultrasound

First-in-human drug trial lowers high blood fats

Decades of dredging are pushing the Dutch Western Scheldt Estuary beyond its ecological limits

A view into the innermost workings of life: First scanning electron microscope with nanomanipulator inaugurated in hesse at Goethe University

Simple method can enable early detection and prevention of chronic kidney disease

S-species-stimulated deep reconstruction of ultra-homogeneous CuS nanosheets for efficient HMF electrooxidation

Mechanical and corrosion behavior of additively manufactured NiTi shape memory alloys

New discovery rewrites the rules of antigen presentation

Researchers achieve chain-length control of fatty acid biosynthesis in yeast

Water interactions in molecular sieve catalysis: Framework evolution and reaction modulation

Shark biology breakthrough: Study tracks tiger sharks to Maui mating hub

Mysterious iron ‘bar’ discovered in famous nebula

World-first tool reduces harmful engagement with AI-generated explicit images

[Press-News.org] SGLT2 inhibitors and kidney outcomes by glomerular filtration rate and albuminuria
JAMA