Discordance in creatinine- and cystatin C–based eGFR and clinical outcomes

JAMA

2025-11-07

(Press-News.org) About The Study: In the Chronic Kidney Disease Prognosis Consortium, 11% of outpatient participants and 35% of hospitalized patients had a cystatin C–based estimated glomerular filtration rate (eGFRcys) that was at least 30% lower than their creatinine-based eGFR (eGFRcr). In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.

Corresponding Authors: To contact the corresponding authors, email Morgan E. Grams, MD, PhD (Morgan.Grams@nyulangone.org) and Josef Coresh, MD, PhD (ckdpc@nyulangone.org).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.17578)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the American Society of Nephrology Kidney Week 2025 meeting.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.17578?guestAccessKey=c3ef42aa-6dc4-4785-8cbb-d0e0c9265fc3&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=110725

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