(Press-News.org) About The Study: In this study across all regions in mainland China, an estimated 1.87 million excess deaths occurred among individuals 30 years and older during the first two months after the end of China’s zero COVID policy, a proactive strategy that deploys mass testing and strict quarantine measures to stamp out any outbreak before it can spread.
Authors: Hong Xiao, Ph.D., and Joseph M. Unger, Ph.D., M.S., of the Fred Hutchinson Cancer Research Center in Seattle, are the corresponding authors.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2023.30877)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.30877?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=082423
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Excess all-cause mortality in China after ending the zero COVID policy
JAMA Network Open
2023-08-24
ELSE PRESS RELEASES FROM THIS DATE:
Assessment of AI chatbot responses to top searched queries about cancer
2023-08-24
About The Study: The findings of this study suggest that artificial intelligence (AI) chatbots generally produce accurate information for the top cancer-related search queries, but the responses are not readily actionable and are written at a college reading level. These limitations suggest that AI chatbots should be used supplementarily and not as a primary source for medical information.
Authors: Abdo E. Kabarriti, M.D., of the State University of New York Downstate Health Sciences University ...
Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models
2023-08-24
HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer. The combination therapy led to durable tumor elimination and significantly improved survival outcomes in preclinical models, leading to the launch of a Phase I clinical trial.
Two studies, published today in Developmental Cell and Cancer Cell, describe why KRAS-targeted monotherapy likely is not enough ...
Breakthrough in β-lactam synthesis using nickel catalysts
2023-08-24
Led by Director CHANG Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis of β-lactam scaffolds, which are structural components frequently found in essential antibiotics such as penicillins and carbapenems. This breakthrough overcomes challenges in β-lactam synthesis to promise streamlined pathways for drug development.
The core chemical structure that makes up penicillins is a four-membered cyclic amide scaffold called chiral ...
Lignocellulose bio-refinery developed for value-added chemical overproduction in yeast
2023-08-24
Lignocellulosic biomass is a renewable feedstock for 2nd-generation biomanufacturing. In particular, efficient co-fermentation of mixed glucose and xylose in lignocellulosic hydrolysates is a key issue in reducing product costs.
However, co-utilization of xylose and glucose in microbes is challenging due to limited xylose assimilation and the glucose repression effect.
Recently, a research group led by Prof. ZHOU Yongjin from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy ...
ChatGPT shows limited ability to recommend guidelines-based cancer treatments
2023-08-24
Correct and incorrect recommendations inter-mingled in one-third of the chatbot’s responses, making errors more difficult to detect
For many patients, the internet serves as a powerful tool for self-education on medical topics. With ChatGPT now at patients’ fingertips, researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, assessed how consistently the artificial intelligence chatbot provides recommendations for cancer treatment that align with National Comprehensive Cancer Network ...
Topography of the genome influences where cancer mutations thrive, study shows
2023-08-24
Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. They found that certain regions of the genome, which exhibit unique features, act as hotspots for the accumulation of mutations.
The findings, published recently in Cell Reports, shed light on how the 3D architecture of the human genome may play a role in the development of various forms of cancer.
The human genome is often visualized as the iconic DNA double helix, composed of long sequences of the letters A, C, G and T. “However, the genome ...
Pioneering treatment highly effective for rare kidney disease
2023-08-24
A pioneering drug for a rare kidney disease prevents organ failure and significantly improves the outcome for patients, new research has confirmed.
Atypical Haemolytic Uraemic Syndrome (aHUS) is a genetic life-threatening condition caused by a defect in the immune system which leads to kidney failure.
Newcastle University, UK, carried out clinical trials into the drug, eculizumab, which eventually led to the NHS approving the treatment for use in patients from 2015.
Now, a study by Newcastle experts, published in Blood, ...
Getting protein factories to run – How deubiquitinating enzymes moonlight as Fubi proteases
2023-08-24
Fubi is produced by cells as a fusion protein with the ribosomal protein S30, and must be separated from S30 by proteases for functioning ribosomes. In immune cells, this by-product of ribosome production is utilized as a secreted signalling molecule, for example to locally reduce the activity of the maternal immune system in the uterus and to thus enable embryos to implant. How Fubi is specifically recognized by proteases and how they distinguish it from ubiquitin was previously unknown.
First author Rachel O’Dea and Malte Gersch explain their research in detail:
What is the discovery that you made and why is it exciting?
Our team revealed ...
Eureka win for researchers behind new anti-cancer strategy
2023-08-24
Associate Professor Tim Thomas and Professor Anne Voss from WEHI (Melbourne, Australia) have been awarded the 2023 UNSW Eureka Prize for Scientific Research.
The prize recognises their groundbreaking research in developing a new class of drugs that can put cancer cells ‘to sleep’ without triggering the harmful side effects caused by conventional cancer treatments, like chemotherapy and radiation.
The Australian Museum Eureka Prizes are among Australia’s most distinguished science awards, honouring excellence across the areas of research and innovation, leadership, science engagement, and school science.
At a glance
Associate Professor Tim Thomas and Professor ...
Cattle farming expansion and unchecked climate change would expose more than 1 billion cows to heat stress
2023-08-24
More than 1 billion cows around the world will experience heat stress by the end of the century if carbon emissions are high and environmental protection is low, according to new research published today in IOP Publishing’s journal Environmental Research Letters.
This would mean cattle farming would face potentially lethal heat stress in much of the world, including Central America, tropical South America, Equatorial Africa, and South and Southeast Asia. The research also found that rapidly reducing greenhouse gas emissions, as well as keeping cattle production close to current levels, would reduce these impacts by at least 50% in Asia, 63% in South America, and ...
LAST 30 PRESS RELEASES:
How microbes control mammalian cell growth
Emergency department pilot program serves rural families
Amid renewable-energy boom, study explores options for electricity market
Study finds improvement in knee pain with exercise and physical therapy
Researchers uncover key mechanism behind chemotherapy-induced nerve damage
Mayo Clinic researchers find enhancing the body’s ‘first responder’ cells may boost immune therapy for cancer
Secret to a long life? In bowhead whales, a protein repairs damaged DNA
MIT study: Identifying kids who need help learning to read isn’t as easy as A, B, C
Plant biomass substance helps combat weeds
Veterans with epilepsy after traumatic brain injury may have higher mortality rates
Who is more likely to lose vision due to high brain pressure?
Scripps Research professor awarded $3.2 million to advance type 1 diabetes research
Anna Wuttig wins Bayer Foundation Early Excellence in Science Award
Electric vehicles outperform gasoline cars in lifetime environmental impact
Kilimanjaro has lost 75 percent of its natural plant species over the last century
Spider web “decorations” may help pinpoint location of captured prey
Ancient tombs reveal the story of Chinese history
1 in 3 university students surveyed from a Parisian suburb report being unable to access desired food, with this food insecurity associated with academic dropout
Researchers uncover oldest 3D burrow systems in Hubei's Shibantan Biota
Discovery of a new principle: chiral molecules adhere to magnets
New algorithm lets autonomous drones work together to transport heavy, changing payloads
Lehigh University team develops computational model to guide neurostimulation therapy for atrial fibrillation
Survival of the blandest: Unusual sharks face highest extinction risk
Research alert: Bioinformatics uncovers regenerative therapy for spinal cord injury
Sustainable chemistry with the help of Artificial Intelligence
Quantum jam sessions teach quantum and jamming
Health care professionals sponsored for H-1B visas in the US
Study shows increase of H1-B visa fees will most impact rural and high-poverty counties
How age affects vaccine responses and how to make them better
MAGIC: AI-assisted laser tag illuminates cancer origins
[Press-News.org] Excess all-cause mortality in China after ending the zero COVID policyJAMA Network Open







