(Press-News.org) Tsukuba, Japan—The search for functional natural compounds that can improve age-related cognitive decline has recently emerged as an important research focus to promote healthy aging. Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess cognitive enhancement properties. In this study, researchers led by the University of Tsukuba investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective in an integrated manner using a senescence-accelerated mouse prone 8 (SAMP8) model.
Following oral administration of TG to SAMP8 mice for 30 days, the Morris water maze test indicated a significant improvement in spatial learning and memory performance compared with SAMP8 mice that did not receive TG. Next, the researchers performed whole-genome transcriptomic analysis of the hippocampus to explore the underlying molecular mechanisms. They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group. Furthermore, the research team found that TG suppressed neuroinflammation by negatively regulating signaling factor Traf6-mediated activation of the transcription factor NF-κB. Additionally, quantitative protein analysis confirmed that the levels of inflammatory cytokines TNF-α and IL-6 were significantly decreased and the levels of neurotransmitters dopamine, noradrenaline, and serotonin were significantly increased in the hippocampus. These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment.
###
This work was supported by DyDo DRINCO and Japan Science and Technology Agency (JST grant number JPMJPF2017)
Original Paper
Title of original paper:
Transcriptomics and Biochemical Evidence of Trigonelline Ameliorating Learning and Memory Decline in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Model by Suppressing Proinflammatory Cytokines and Elevating Neurotransmitter Release
Journal:
Geroscience
DOI:
10.1007/s11357-023-00919-x
Correspondence
Professor ISODA, Hiroko
Institute of Life and Environmental Sciences, University of Tsukuba
KAGAWA, Tamami
DyDo DRINCO, INC.
Related Link
Institute of Life and Environmental Sciences
END
Trigonelline derived from coffee improves cognitive functions
2023-09-22
ELSE PRESS RELEASES FROM THIS DATE:
Discovery of histidine methylation as a new post-translational modification of histone proteins
2023-09-22
Tsukuba, Japan—In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained within the nucleus. Various post-translational modifications (for example, addition of chemical groups) occur on histones. Among them, the methylation of residues of lysine, which is one of the amino acids that make up histones, regulates the folding of genomic DNA and acts as a switch to turn gene transcription on and off.
The research group has discovered the methylation of histidine residues as a new post-translational ...
DNA methylation-dependent epigenetic regulation of verticillium dahliae virulence in plants
2023-09-22
This study is led by Dr Cheng-Guo Duan (Center of Excellence in Molecular Plant Sciences, Chinese Academy of Science). As a conserved epigenetic mark, DNA cytosine methylation at 5’ position (5-mC) plays important roles in multiple biological processes including plant immunity. While, it remains still elusive about the involvement of DNA methylation in the determinants of virulence of phytopathogenic fungi. Verticillium dahliae, one of the major causal pathogens of Verticillium wilt disease that causes great losses in many crops, has a wide host range. Due to the lack of natural disease-resistant ...
Generating homozygous mutant populations of barley microspores by ethyl methanesulfonate treatment
2023-09-22
This study combined expertise in barley genetics and genomics from the research group led by Dr. Ping Yang (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences) and that in barley microspore culturing led by Dr. Chenghong Liu (Biotech Research Institute, Shanghai Academy of Agricultural Sciences), in order to address the time- and space-cost issue in developing homozygous induced mutants, which are very important genetic resources in theoretical researches as well as pre-breeding.
The researchers applied chemical mutagenesis (ethyl ...
Efficient training for artificial intelligence
2023-09-22
Artifical intelligence not only affords impressive performance, but also creates significant demand for energy. The more demanding the tasks for which it is trained, the more energy it consumes. Víctor López-Pastor and Florian Marquardt, two scientists at the Max Planck Institute for the Science of Light in Erlangen, Germany, present a method by which artificial intelligence could be trained much more efficiently. Their approach relies on physical processes instead of ...
Re-wetting is key for boosting CO2 storage in southern peatlands
2023-09-22
DURHAM, N.C. – Maintaining a water level between 20 and 30 centimeters below the local water table will boost southern peatlands’ carbon storage and reduce the amount of climate-warming carbon dioxide (CO2) and methane they release back into the atmosphere during dry periods by up to 90%, a new Duke University study finds.
“We could immediately reduce U.S. carbon losses by 2% to 3% of our total national goal by applying this guideline on about 100,000 acres of restored or partially restored peatlands currently found across ...
New study unveils direct synthesis of FCMs via solid-state mechanochemical reaction between graphite and PTFE
2023-09-22
A research team, led by Professor Jong-Beom Baek and his team in the School of Energy and Chemical Engineering at UNIST have achieved a significant breakthrough in battery technology. They have developed an innovative method that enables the safe synthesis of fluorinated carbon materials (FCMs) using polytetrafluoroethylene (PTFE) and graphite.
Fluorinated carbon materials have garnered considerable attention due to their exceptional stability, attributed to the strong C-F bonding—the strongest among carbon single bonds. However, traditional methods of fluorination involve highly toxic reagents such as hydrofluoric acid (HF), making them unsuitable for practical ...
Gold nanoclusters can improve electrochemical water splitting to produce hydrogen
2023-09-22
As energy demand continues to rise, research into new, efficient renewable and clean energy sources is an urgent priority. Currently, renewable energy sources like solar, wind, tide, and geothermal make up less than 40% of the current energy demand. Increasing this percentage and reducing the amount of fossil fuels used will require other, more efficient renewable and clean energy sources.
Hydrogen is a promising alternative, but it is currently produced using steam reforming, which is inefficient and produces CO2 emissions. Electrochemical water splitting, also called ...
Study finds connection between gut microbiome and bone density
2023-09-22
BOSTON – There is growing evidence that a relative abundance of certain gut microbes may be related to skeletal health, according to a new study published in Frontiers in Endocrinology. If confirmed by additional research, the findings could provide the opportunity to alter gut microbiomes to achieve better bone health, as scientists learn more about “osteomicrobiology,” a new term recently used to characterize this relationship.
Due to the lack of large-scale human studies of the gut microbiome and skeletal health, researchers led by Paul C. Okoro, Data Scientist II at Hebrew SeniorLife and Hinda and Arthur Marcus Institute for ...
A dendritic cell vaccine was safe and induced immune responses in patients with multiple myeloma
2023-09-22
Bottom Line: A dendritic cell vaccine administered before and after autologous stem cell transplant (ASCT) was safe and immunogenic and was associated with durable clinical responses in patients with high-risk multiple myeloma.
Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR)
Authors: Frederick L. Locke, MD, chair of the Blood and Marrow Transplant and Cellular Immunotherapy Department at Moffitt Cancer Center, was the senior author of the study.
Background: “Multiple ...
One-stop implementation from signal detection to processing
2023-09-22
In order to explore brain disorders and discover potential treatments, it is crucial to analyze and interpret the signals transmitted by the brain. Although neural probes attached to the brain can effectively detect subtle bio- signals, they lack the ability to amplify and process these signals, necessitating the use of a separate amplifier. The research team identified a solution in common household “inkjet printers” that have been widely available for a long time.
A collaborative research team led by Professor Sungjune Jung (Department of Materials Science and Engineering, Department of Convergence IT Engineering) with PhD candidate ...