(Press-News.org) Ever since Antonie van Leeuwenhoek discovered the world of bacteria through a microscope in the late seventeenth century, humans have tried to look deeper into the world of the infinitesimally small.
There are, however, physical limits to how closely we can examine an object using traditional optical methods. This is known as the ‘diffraction limit’ and is determined by the fact that light manifests as a wave. It means a focused image can never be smaller than half the wavelength of light used to observe an object.
Attempts to break this limit with “super lenses” have all hit the hurdle of extreme visual losses, making the lenses opaque. Now physicists at the University of Sydney have shown a new pathway to achieve superlensing with minimal losses, breaking through the diffraction limit by a factor of nearly four times. The key to their success was to remove the super lens altogether.
The research is published today in Nature Communications.
The work should allow scientists to further improve super-resolution microscopy, the researchers say. It could advance imaging in fields as varied as cancer diagnostics, medical imaging, or archaeology and forensics.
Lead author of the research, Dr Alessandro Tuniz from the School of Physics and University of Sydney Nano Institute, said: “We have now developed a practical way to implement superlensing, without a super lens.
“To do this, we placed our light probe far away from the object and collected both high- and low-resolution information. By measuring further away, the probe doesn’t interfere with the high-resolution data, a feature of previous methods.”
Previous attempts have tried to make super lenses using novel materials. However, most materials absorb too much light to make the super lens useful.
Dr Tuniz said: “We overcome this by performing the superlens operation as a post-processing step on a computer, after the measurement itself. This produces a ‘truthful’ image of the object through the selective amplification of evanescent, or vanishing, light waves.
Co-author, Associate Professor Boris Kuhlmey, also from the School of Physics and Sydney Nano, said: “Our method could be applied to determine moisture content in leaves with greater resolution, or be useful in advanced microfabrication techniques, such as non-destructive assessment of microchip integrity.
“And the method could even be used to reveal hidden layers in artwork, perhaps proving useful in uncovering art forgery or hidden works.”
Typically, superlensing attempts have tried to home in closely on the high-resolution information. That is because this useful data decays exponentially with distance and is quickly overwhelmed by low-resolution data, which doesn’t decay so quickly. However, moving the probe so close to an object distorts the image.
“By moving our probe further away we can maintain the integrity of the high-resolution information and use a post-observation technique to filter out the low-resolution data,” Associate Professor Kuhlmey said.
The research was done using light at terahertz frequency at millimetre wavelength, in the region of the spectrum between visible and microwave.
Associate Professor Kuhlmey said: “This is a very difficult frequency range to work with, but a very interesting one, because at this range we could obtain important information about biological samples, such as protein structure, hydration dynamics, or for use in cancer imaging.”
Dr Tuniz said: “This technique is a first step in allowing high-resolution images while staying at a safe distance from the object without distorting what you see.
“Our technique could be used at other frequency ranges. We expect anyone performing high-resolution optical microscopy will find this technique of interest.”
DOWNLOAD images at this link.
INTERVIEWS
Dr Alessandro Tuniz Associate Professor Boris Kuhlmey
School of Physics School of Physics
The University of Sydney The University of Sydney
alessandro.tuniz@sydney.edu.au boris.kuhlmey@sydne.edu.au
MEDIA ENQUIRIES
Marcus Strom | marcus.strom@sydney.edu.au | +61 474 269 459
Research paper: A Tuniz & B Kuhlmey, ‘Subwavelength terahertz imaging via virtual superlensing in the radiating near field’, Nature Communications (2023)
DOI: 10.1038/s41467-023-41949-5 (Available on request)
DECLARATION
The authors declare no competing financial interests. Research was in part funded by the Australian Research Council.
END
Superlensing without a super lens: physicists boost microscopes beyond limits
New technique could be used in medical diagnostics and advanced manufacturing
2023-10-18
ELSE PRESS RELEASES FROM THIS DATE:
Collaborative study focuses on using computer algorithms to find molecular adaptations to improve COVID-19 drugs
2023-10-18
As the COVID-19 pandemic scattered and isolated people, researchers across Virginia Tech connected for a data-driven collaboration seeking improved drugs to fight the disease and potentially many other illnesses.
A multidisciplinary collaboration spanning several colleges at Virginia Tech resulted in a newly published study, “Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like Scenarios,” in the Journal of Physical Chemistry Letters.
The study focuses on using computer algorithms to generate adaptations to ...
Study predicts potential for 110% electricity increases in U.S. urban buildings
2023-10-18
A research study led by University of Oklahoma assistant professor Chenghao Wang and recently published in the journal Nature Communications tackled the critical issue of how city-scale building energy consumption in urban environments will evolve under the influence of climate change.
Fossil fuels account for approximately 40% of all building energy use in urban city centers in the United States, and the U.S. Energy Information Administration reports that residential and commercial buildings in U.S. cities are one of the major energy ...
Open access: Need to move away from transformative agreements
2023-10-18
Sweden is far ahead when it comes to promoting open access to scholarly publications. But there is risk of getting stuck in a permanent transformation that favours large commercial publishers. A new report from the Association of Swedish Higher Education Institutions develops a strategy on how to work in negotiations with the publishers.
In 2021, the Association of Swedish Higher Education Institutions (Sveriges universitets- och högskoleförbund, SUHF) convened a “Beyond transformative agreements” working group (the BTA group) to lay the foundation for further advancing the transition to open access. Now, the group ...
Graz University of Technology study on e-scooter accidents: more helmets and less speed reduce the injury risk
2023-10-18
The use of e-scooters has increased significantly in recent years, but so has the number of accidents involving this relatively new form of transport. At the same time, knowledge about injury mechanisms in this area was still very limited. In the project SURF, funded by Zukunftsfonds Steiermark, the Vehicle Safety Institute at Graz University of Technology (TU Graz) investigated this topic using Human Body Models and derived recommendations to reduce the injury risk in e-scooter accidents.
Put on a helmet, decrease speed and get off the pavement
As ...
Reef-devouring predator survives coral bleaching and feasts on the survivors
2023-10-18
Research conducted by marine biologists from the University of Sydney has found juvenile crown-of-thorns starfish can withstand tremendous heatwaves well above levels that kill coral. These starfish then develop into carnivorous predators that devour reefs just as they begin to regrow.
Crown-of-thorns starfish are native to the Great Barrier Reef and found in the Indo-Pacific region, but they are classified as a species of concern because the damage large populations cause to coral is more significant than any other species. ...
Does SARS-CoV-2 infection have urological effects?
2023-10-18
Research published in the Journal of Internal Medicine indicates that SARS-CoV-2 infection may worsen lower urinary tract symptoms (LUTS) in men.
The study included 17,986 men receiving medication for LUTS within the public healthcare system of Hong Kong in 2021–2022, half of whom had SARS-CoV-2 infection. The group with SARS-CoV-2 had significantly higher rates of retention of urine (4.55% versus 0.86%); blood in the urine (1.36% versus 0.41%); clinical urinary tract infection (4.31% versus 1.49%); bacteria in the urine (9.02% versus 1.97%); and addition of 5-alpha reductase inhibitors, which are drugs prescribed for enlarged prostate. (0.50% versus 0.02%). These urological ...
How did the initial COVID-19 wave affect mental health in the UK?
2023-10-18
New research published in Economic Inquiry reports substantial increases in psychological distress in the UK during the first wave of the COVID-19 pandemic.
Mental health effects were more pronounced for females; younger individuals; Black, Asian, and minority ethnic communities; and migrants. Also, people who had financial worries, loneliness, or were living in overcrowded dwellings experienced significantly worse mental health deterioration during the first wave.
The study used data from the UKHLS, also known as Understanding Society, which is a household panel dataset that captures, among other things, information from adults about their economic and social circumstances, ...
Heat-tolerant predatory sea stars will likely be a threat to coral during climate change
2023-10-18
Population outbreaks of the crown-of-thorns sea star (COTS), a predator of coral, can cause widespread coral mortality. COTS are herbivorous as juveniles but then switch to coral consumption as they grow to adulthood. When researchers exposed juvenile COTS to heat stress scenarios at time and temperature durations designed to reflect conditions that cause coral bleaching and mortality, juveniles exhibited tolerance to heatwave conditions well above levels that kill coral.
The findings, which are published in Global Change Biology, indicate that juvenile COTS are likely to persist as major coral predators in reefs already vulnerable to the effects of climate change.
“This ...
Does COVID-19 affect Alzheimer’s disease risk?
2023-10-18
The various neurological symptoms that patients with COVID-19 have experienced suggest that viral infections may increase the risk of neurodegeneration, which could in turn contribute to the development of conditions such as Alzheimer’s disease (AD). A review in the Journal of Neurochemistry highlights the potential mechanistic links between COVID-19 and AD.
The authors note that age is the largest contributing factor to AD and COVID-19, and both appear to enhance the effects of the other, with potentially synergistic effects on neurodegeneration.
“I believe over the next several ...
Can planting multiple crops in the same plot improve agricultural production and sustainability?
2023-10-18
Agricultural management has typically focused on increasing yields, but there is an increasing need for sustainable food production that limits negative impacts on the environment. A new study published in Grassland Research provides insights into the potential benefits of diversifying agricultural practices, revealing how different mixtures of plant species can improve production, quality, and conservation.
For the study, investigators planted multiple species in different grassland plots, manipulating plant species richness from one to six species spanning three functional groups ...
LAST 30 PRESS RELEASES:
New ‘scimitar-crested’ Spinosaurus species discovered in the central Sahara
“Cyborg” pancreatic organoids can monitor the maturation of islet cells
Technique to extract concepts from AI models can help steer and monitor model outputs
Study clarifies the cancer genome in domestic cats
Crested Spinosaurus fossil was aquatic, but lived 1,000 kilometers from the Tethys Sea
MULTI-evolve: Rapid evolution of complex multi-mutant proteins
A new method to steer AI output uncovers vulnerabilities and potential improvements
Why some objects in space look like snowmen
Flickering glacial climate may have shaped early human evolution
First AHA/ACC acute pulmonary embolism guideline: prompt diagnosis and treatment are key
Could “cyborg” transplants replace pancreatic tissue damaged by diabetes?
Hearing a molecule’s solo performance
Justice after trauma? Race, red tape keep sexual assault victims from compensation
Columbia researchers awarded ARPA-H funding to speed diagnosis of lymphatic disorders
James R. Downing, MD, to step down as president and CEO of St. Jude Children’s Research Hospital in late 2026
A remote-controlled CAR-T for safer immunotherapy
UT College of Veterinary Medicine dean elected Fellow of the American Academy of Microbiology
AERA selects 34 exemplary scholars as 2026 Fellows
Similar kinases play distinct roles in the brain
New research takes first step toward advance warnings of space weather
Scientists unlock a massive new ‘color palette’ for biomedical research by synthesizing non-natural amino acids
Brain cells drive endurance gains after exercise
Same-day hospital discharge is safe in selected patients after TAVI
Why do people living at high altitudes have better glucose control? The answer was in plain sight
Red blood cells soak up sugar at high altitude, protecting against diabetes
A new electrolyte points to stronger, safer batteries
Environment: Atmospheric pollution directly linked to rocket re-entry
Targeted radiation therapy improves quality of life outcomes for patients with multiple brain metastases
Cardiovascular events in women with prior cervical high-grade squamous intraepithelial lesion
Transplantation and employment earnings in kidney transplant recipients
[Press-News.org] Superlensing without a super lens: physicists boost microscopes beyond limitsNew technique could be used in medical diagnostics and advanced manufacturing







