Multitarget stool RNA test for colorectal cancer screening

JAMA

2023-10-23

(Press-News.org) About The Study: In a clinical trial that included 8,920 participants, a noninvasive, multitarget stool RNA test (ColoSense) for colorectal cancer screening showed high sensitivity for colorectal neoplasia (colorectal cancer and advanced adenoma) with significant improvement in sensitivity relative to the fecal immunochemical test. Specificity for no lesions on colonoscopy was comparable to existing molecular diagnostic tests.

Authors: Erica K. Barnell, M.D., Ph.D., of the Washington University School of Medicine in St. Louis, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2023.22231)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being released to coincide with presentation at the American College of Gastroenterology 2023 Annual Scientific Meeting.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time

https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.22231?guestAccessKey=a43a7e6d-f8f7-4c6d-b106-8aac7b27149c&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=102323

END

ELSE PRESS RELEASES FROM THIS DATE:

Plants transformed into detectors of dangerous chemicals

2023-10-23

What if your house plant could tell you your water isn’t safe? Scientists are closer to realizing this vision, having successfully engineered a plant to turn beet red in the presence of a banned, toxic pesticide. To achieve this, UC Riverside researchers had to solve an engineering puzzle: how to enable a plant to sense and react to a chemical in the environment without damaging its ability to function normally in all other respects. “The biggest piece here is we’ve created an environmental sensor without modifying ...

How long should kids isolate after they’ve contracted COVID-19?

2023-10-23

School policies that require students with COVID-19 to stay out of the classroom for five days are more than sufficient. That’s because children infected with the Omicron variant remained infectious for a median time of three days after testing positive for the virus, according to a study by the USC Schaeffer Center for Health Policy & Economics and Stanford University. “We're basically saying five days is more than sufficient; public-health and education leaders may consider shorter durations,” said co-author Neeraj ...

Homeless people are 16 times more likely to die suddenly

2023-10-23

A study led by UC San Francisco has found that people who are experiencing homelessness have a 16-fold higher rate of sudden death from heart attacks, as well as other causes. The study focused on San Francisco County, which has one of the nation’s highest concentrations of homeless people. It found that the rate of sudden cardiac death was 7 times higher than the general population. Some of these deaths may have been prevented with defibrillators and other public policy measures to improve health in this vulnerable population, according to the authors. The paper published ...

New study shows surprising effects of fire in North America’s boreal forests

2023-10-23

A new study, using a first-of-its-kind approach to analyze satellite imagery from boreal forests over the last three decades, found that fire may be changing the face of the region in a way researchers did not previously anticipate. Historically, fires in North American boreal forests have led to coniferous trees being supplanted by deciduous trees, which are faster growing, take up more carbon and reflect more light, leading to cooling of the climate and decreased likelihood of fire. The study, led by Northern Arizona University and published today in Nature Climate Change, found that, surprisingly, while forests do become more deciduous, ...

Chemists, engineers craft adjustable arrays of microscopic lenses

2023-10-23

They number in the thousands, light striking the phalanx of lenses arrayed on a face in geometric pattern, the beams refracting through transparent mounds no wider than a hair. A fly’s eye boasts roughly 4,000 microscopic lenses, a honeybee’s up to twice that many. These lenses, though, belong not to a compound eye but to polydimethylsiloxane — a flexible polymer long ranking as a favored playground of Nebraska’s Stephen Morin and his band of fellow chemists. With the aid of engineers Ruiguo Yang and Grayson Minnick, Morin’s team can now arrange and ...

Researchers develop DANGER analysis tool for the safer design of gene editing

2023-10-23

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The DANGER analysis overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research. Their ...

Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery

2023-10-23

HOUSTON ― A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center. The findings, published today in the New England Journal of Medicine, were first presented at the American Association for Cancer Research (AACR) Annual Meeting 2023. The AEGEAN trial evaluated durvalumab given perioperatively, meaning therapy ...

KICT develops scan to BIM for reverse engineering from 3D vision data

2023-10-23

Korea Institute of Civil Engineering and Building Technology (KICT, President Kim Byung-suk) has developed building scan to BIM (Building Information Modeling)-based reverse engineering technology required for 3D geospatial information modeling domains such as digital twin information modeling. Scan to BIM-based reverse engineering technology was studied to prevent errors and rework caused by manual work when modeling shapes or BIM from 3D scan data. Existing reverse engineering work is either done based on a lot of manual work or semi-automatically using expensive overseas software. KICT Research Fellow Dr. Kang Tae-wook ...

Crystals brought back by astronauts show that the Moon is 40 million years older than scientists thought

2023-10-23

More than 4 billion years ago, when the Solar System was still young and the Earth was still growing, a giant object the size of Mars crashed into the Earth. The biggest piece that broke off of the early Earth formed our Moon. But precisely when this happened has remained a mystery. In a new study in the journal Geochemical Perspectives Letters, researchers used crystals brought back from the Moon by Apollo astronauts in 1972 to help pinpoint the time of the Moon’s formation. Their discovery pushes back the age of the Moon by 40 million years, to at least 4.46 billion years old. “These ...

Probiotics delivered in biofilm state protect the intestines and brain in NEC model

2023-10-23

(COLUMBUS, Ohio) – Necrotizing enterocolitis (NEC) is a debilitating and deadly condition that affects infants who were born preterm. In NEC cases, intestinal tissues become inflamed, and in severe cases there is ischemia and death of the involved intestines. Treatment for NEC often involves surgery to remove the dying tissue. “Even after decades of research, little has changed in terms of prognosis for infants who develop NEC,” says Gail Besner, MD, pediatric surgeon and principal investigator in the Center for Perinatal Research at Nationwide Children’s. ...

Cleveland Clinic researchers build first large-scale atlas of how immune cells react to mutations during cancer immunotherapy

Pioneering quantum computer research continues in Baden-Württemberg

Discovery of orbital angular momentum monopoles enables orbital electronics with chiral materials

[Press-News.org] Multitarget stool RNA test for colorectal cancer screening
JAMA

Multitarget stool RNA test for colorectal cancer screening

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: