PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Apoptotic cells may drive cell death in hair follicles during regression cycle

Apoptotic cells may drive cell death in hair follicles during regression cycle
2023-10-23
(Press-News.org)

“Revealing the stem cell niche self-renewal dynamics is important not only for understanding tissue homeostasis but also for understanding the initiation of cancer [7].”

BUFFALO, NY- October 23, 2023 – A new research paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, “Apoptotic cells may drive cell death in hair follicles during their regression cycle.”

Intravital microscopy in live mice has shown that the elimination of epithelial cells during hair follicle regression involves supra-basal cell differentiation and basal cell apoptosis through synergistic action of TGF-β (transforming growth factor) and mesenchymal-epithelial interactions. In this process the basal epithelial cells are not internally committed to death and the mesenchymal dermal papilla (DP) plays an essential role in death induction. Given that DP cells are not necessary for completion of the cycle, only for its initiation, it is still an open question as to the mechanism that leads to the propagation of apoptosis towards the regenerative stem cell population.

In their new study, researchers Bradley D. Keister, Kailin R. Mesa and Krastan B. Blagoev from the National Science Foundation, The Jane Coffin Childs Memorial Fund for Medical Research, Yale School of Medicine, Johns Hopkins University, Bulgarian Academy of Sciences, and Sorbonne Université performed a quantitative analysis of the length of hair follicles to investigate their regression cycle. 

“In this paper we introduced a mathematical model of the hair follicle regression cycle that postulates that the regression is initiated by the dermal papilla, but that this signal affects only the cells adjacent to it.”

The data are consistent with a propagation mechanism driven by apoptotic cells inducing apoptosis in their neighboring cells. The observation that the apoptosis slows down as the apoptotic front approaches the stem cells at the end of the follicle is consistent with a gradient of a pro-survival signal sent by these stem cells. An experiment that can falsify this mechanism is proposed.

“In conclusion, hair follicle regression may be governed by cell-cell induced programmed cell death, which slows down as the stem cell compartment is approached and does not affect the stem cell compartment from which the growth phase is initiated. The class of models introduced here can be used to describe the renewal kinetics of other stem cell niches like the intestinal stem cell niche [18].”

 

Read the full study: DOI: https://doi.org/10.18632/oncotarget.28529 

Correspondence to: Krastan B. Blagoev

Email: kblagoev@nsf.gov 

Keywords: hair follicle, stem cells, regression cycle, mathematical model, analysis
 

About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:

X, formerly known as Twitter  Facebook  YouTube  Instagram  LinkedIn  Pinterest  LabTube Soundcloud  

Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28529 

Click here to subscribe to Oncotarget publication updates.

For media inquiries, please contact: media@impactjournals.com.

 

Oncotarget Journal Office

6666 East Quaker Str., Suite 1A

Orchard Park, NY 14127

Phone: 1-800-922-0957 (option 2)

###

END


[Attachments] See images for this press release:
Apoptotic cells may drive cell death in hair follicles during regression cycle Apoptotic cells may drive cell death in hair follicles during regression cycle 2 Apoptotic cells may drive cell death in hair follicles during regression cycle 3

ELSE PRESS RELEASES FROM THIS DATE:

$3.6 million NIH award funds research to treat painful diabetic neuropathy

$3.6 million NIH award funds research to treat painful diabetic neuropathy
2023-10-23
COLUMBUS, Ohio – A $3.6 million award from the National Institutes of Health will allow neurosurgical, neurology and neuroscience researchers at The Ohio State University Wexner Medical Center and College of Medicine to test a novel diagnosis and treatment combination for painful diabetic neuropathy. The approach combines spinal cord stimulation with measurement of small fiber nerve activity using a patent-pending device called Detecting Early Neuropathy (DEN). Diabetes is a growing health concern worldwide, ...

Superdeep diamonds provide a window on supercontinent growth

Superdeep diamonds provide a window on supercontinent growth
2023-10-23
Washington, DC—Diamonds contain evidence of the mantle rocks that helped buoy and grow the ancient supercontinent Gondwana from below, according to new research from a team of scientists led by Suzette Timmerman—formerly of the University of Alberta and now at the University of Bern—and including Carnegie’s Steven Shirey, Michael Walter, and Andrew Steele. Their findings, published in Nature, demonstrate that superdeep diamonds can provide a window through space and time into the supercontinent growth and formation ...

American Cancer Society awards pilot funding to University of Cincinnati Cancer Center for early-stage investigators

American Cancer Society awards pilot funding to University of Cincinnati Cancer Center for early-stage investigators
2023-10-23
The American Cancer Society has awarded the University of Cincinnati Cancer Center an Institutional Research Grant. Cancer Center member David Plas, PhD, is primary investigator for the grant, with members Maria Czyzyk-Krzeska, MD, PhD, and Kathryn Wikenheiser-Brokamp, MD, PhD, serving as co-principal investigators. The American Cancer Society awards Institutional Research Grants to academic and nonprofit organizations that have a track record of outstanding cancer research and a pool of experienced researchers who can mentor junior faculty. The purpose is to support early-stage ...

Climate is increasing risk of high toxin concentrations in Northern US lakes

Climate is increasing risk of high toxin concentrations in Northern US lakes
2023-10-23
Washington, DC— As climate change warms the Earth, higher-latitude regions will be at greater risk for toxins produced by algal blooms, according to new research led by Carnegie’s Anna Michalak, Julian Merder, and Gang Zhao. Their findings, published in Nature Water, identify water temperatures of 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit) as being at the greatest risk for developing dangerous levels of a common algae-produced toxin called microcystin.   Harmful algal blooms result when bodies of water get overloaded with nitrogen and phosphorus ...

Breastfeeding in the setting of substance use

Breastfeeding in the setting of substance use
2023-10-23
The Academy of Breastfeeding Medicine (ABM) has released new literature-based recommendations related to breastfeeding in the setting of substance use and substance use disorder (SUD) treatments. The new clinical protocol is published in the peer-reviewed journal Breastfeeding Medicine. Click here to read the article now. Miriam Harris, MD and Elisha Wachman, MD, from Boston Medical Center, and coauthors, provide breastfeeding recommendations in the setting of non-prescribed opioid, stimulant, sedative-hypnotic, alcohol, nicotine, and cannabis use, and SUD treatments. They also offer guidance on the use of toxicology testing in breastfeeding ...

New exoplanet-informed research sets clearer bounds on the search for radio technosignatures

New exoplanet-informed research sets clearer bounds on the search for radio technosignatures
2023-10-23
A new study leverages the NASA Exoplanet Archive and planetary system simulations to make narrowband SETI searches more efficient. October 23, 2023, Mountain View, CA -- In a new study published in the Astronomical Journal, researchers used the known population of exoplanets and extrapolated to the much larger, unknown population of exoplanets to set better thresholds for planetary effects on signals from ETIs (extraterrestrial intelligences). The prior recommendation for the threshold “drift rate” contribution, caused by a planet’s motion around its host star, was 200 nHz. In this work, lead ...

Navigating the future of skin health: The 14Th International Conference on Skin Ageing & Challenges 2023

Navigating the future of skin health: The 14Th International Conference on Skin Ageing & Challenges 2023
2023-10-23
Lisbon, Portugal – 23 October, 2023 The International Society of Microbiota (ISM) is proud to present the 14th International Conference on Skin Ageing & Challenges 2023. This monumental event will unfold at the Altis Grand Hotel in Lisbon, Portugal, and virtually, on November 9-10, 2023. Skin ageing, a multifaceted issue combining both basic research, mechanistic, clinical aspects and health concerns, is gaining significant attention in the scientific community. This year’s conference promises to be a beacon of innovation, ...

Gut fungi's lasting impact on severe COVID-19 immune response

2023-10-23
Certain gut-dwelling fungi flourish in severe cases of COVID-19, amplifying the excessive inflammation that drives this disease while also causing long-lasting changes in the immune system, according to a new study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian. This discovery identifies a group of patients who may benefit from specialized, but yet-to-be determined treatments. Utilizing patient samples and preclinical models, the research team determined that the growth of fungi in the intestinal ...

Who were the first modern humans to settle in Europe?

Who were the first modern humans to settle in Europe?
2023-10-23
Before modern humans settled definitively in Europe, other human populations left Africa for Europe beginning approximately 60,000 years ago, albeit without settling for the long term. This was due to a major climatic crisis 40,000 years ago, combined with a super-eruption originating from the Phlegraean Fields volcanic area near current-day Naples, subsequently precipitating a decline in ancient European populations. To determine who the first modern humans to settle definitively in Europe were, a team led by CNRS scientists1 analysed the genome of two skull ...

Alem & Narayanan advancing infectious disease capabilities through Biomedical Research Laboratory core support

2023-10-23
Alem & Narayanan Advancing Infectious Disease Capabilities Through Biomedical Research Laboratory Core Support Farhang Alem, Interim Director of the Biomedical Research Laboratory, Institute for Biohealth Innovation, and Aarthi Narayanan, Professor, Biology, received funding for the project: "Advancing Infectious Disease Capabilities through BRL Core Support." As part of this project, Alem and Narayanan will: 1) implement a comprehensive BSL-3 facilities preventative maintenance and upgrade plan to ensure continuity of operations, compliance with federal regulations, and a safe and secure facility; 2) enhance safety ...

LAST 30 PRESS RELEASES:

Premenstrual symptoms linked to increased risk of cardiovascular disease

Newly discovered remains of ancient river landscapes control ice flow in East Antarctica

Newly discovered interstellar object 'may be oldest comet ever seen'

Animal-inspired AI robot learns to navigate unfamiliar terrain

Underserved youth less likely to visit emergency department for concussion in Ontario, study finds

‘Molecular shield’ placed in the nose may soon treat common hay fever trigger

Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂

Groundbreaking quantum study puts wave-particle duality to work

Weekly injection could be life changing for Parkinson’s patients

Toxic metals linked to impaired growth in infants in Guatemala

Being consistently physically active in adulthood linked to 30–40% lower risk of death

Nerve pain drug gabapentin linked to increased dementia, cognitive impairment risks

Children’s social care involvement common to nearly third of UK mums who died during perinatal period

‘Support, not judgement’: Study explores links between children’s social care involvement and maternal deaths

Ethnic minority and poorer children more likely to die in intensive care

Major progress in fertility preservation after treatment for cancer of the lymphatic system

Fewer complications after additional ultrasound in pregnant women who feel less fetal movement

Environmental impact of common pesticides seriously underestimated

The Milky Way could be teeming with more satellite galaxies than previously thought

New study reveals surprising reproductive secrets of a cricket-hunting parasitoid fly

Media Tip Sheet: Symposia at ESA2025

NSF CAREER Award will power UVA engineer’s research to improve drug purification

Tiny parasitoid flies show how early-life competition shapes adult success

New coating for glass promises energy-saving windows

Green spaces boost children’s cognitive skills and strengthen family well-being

Ancient trees dying faster than expected in Eastern Oregon

Study findings help hone precision of proven CVD risk tool

Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later

Introducing BioEmu: A generative AI Model that enables high-speed and accurate prediction of protein structural ensembles

Replacing mutated microglia with healthy microglia halts progression of genetic neurological disease in mice and humans

[Press-News.org] Apoptotic cells may drive cell death in hair follicles during regression cycle