PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Parkinson disease and normal aging

Parkinson disease and normal aging
2023-11-01
(Press-News.org)

“Our principal component analyses showed a significant relationship between centro-cingulate cholinergic afferent changes and age in our Parkinson disease subjects.”

BUFFALO, NY- November 1, 2023 – A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, “Cholinergic centro-cingulate network in Parkinson disease and normal aging.”

In their new perspective, researchers Nicolaas I. Bohnen, Sygrid van der Zee and Roger Albin from University of Michigan, Veterans Administration Ann Arbor Healthcare System, University of Groningen, and the University Medical Center Groningen discussed Parkinson disease (PD). Decreased cholinergic binding within the recently identified centro-cingulate brain network has been shown to robustly correlate with the severity of cognitive impairment in PD. This network with key hubs within the cingulum, operculum and peri-central cortical regions also correlates with elements of parkinsonian motor impairments, including postural instability and gait difficulties, such as falls or freezing. 

“We recently reported novel data-driving findings suggesting that cholinergic innervation deficits in centro-cingulate brain regions may be an important contributor to cognitive impairments in PD [1].”

MRI neuroimaging studies have shown that the anterior midcingulate cortex is a key node for cognitive aspects of movement generation, i.e., intentional motor control. Recent evidence also suggests a novel aspect of organization of primary motor cortex, describing “effector” regions for fine movement control intercalated with interlinked “inter-effector” regions devoted to whole-body control. 

A distinguishing feature of inter-effector regions is tight linkage to the cingular and opercular regions. Such inter-effector regions have been proposed to be part of a greater somato-cognitive action network necessary for integration of goals and movement. Recent evidence also points to vulnerabilities of cholinergic nerve terminals in the centro-cingulate network in older non-PD adults. These features of normal aging underscore that cortical cholinergic terminal losses in age-associated neurodegenerative disorders are likely not exclusively the result of disease-specific etiologies but also related to otherwise normal aging. 

“Practical implications of this overlap are that addressing disease-specific and general aging etiologies involved in neurodegeneration, may be of benefit in age-associated neurodegenerative disorders where significant cholinergic systems degeneration is present.”
 

Read the full paper: DOI: https://doi.org/10.18632/aging.205209 

Corresponding Author: Nicolaas I. Bohnen

Corresponding Email: nbohnen@umich.edu 

Keywords: centro-cingulate network, cholinergic, cognition, motor, Parkinson disease

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205209

 

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud Facebook X, formerly known as Twitter Instagram YouTube LabTube LinkedIn Reddit Pinterest  

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

END


[Attachments] See images for this press release:
Parkinson disease and normal aging Parkinson disease and normal aging 2

ELSE PRESS RELEASES FROM THIS DATE:

Harold Hwang awarded 2024 McGroddy Prize for discovering exotic new materials

2023-11-01
The marvels of modern technology – computers that fit in your hand, internet-connected refrigerators, and self-driving cars – are only possible thanks to the magic of materials like silicon. Likewise, the sci-fi gadgets of tomorrow will spring from the exotic new materials scientists are discovering today. Harold Hwang, a physicist at the Department of Energy's SLAC National Accelerator Laboratory and Stanford University, has brought this future closer by sandwiching carefully crafted materials together and seeing what happens where they touch. His experimentation has uncovered a host of compounds with surprising ...

University of Cincinnati study: Strawberry consumption may reduce dementia risk for middle-aged individuals

University of Cincinnati study: Strawberry consumption may reduce dementia risk for middle-aged individuals
2023-11-01
New research from the University of Cincinnati found that daily strawberry consumption could help reduce the risk of dementia for certain middle-aged populations. The research was recently published in the journal Nutrients. Research background In 2022, UC’s Robert Krikorian, PhD, and his team published research that found adding blueberries to the daily diets of certain middle-aged populations may lower the chances of developing late-life dementia. He said the current research into strawberries is an extension to the blueberry research. “Both strawberries and blueberries contain antioxidants called anthocyanins, ...

November issues of American Psychiatric Association journals cover new insights in psychotic disorders, barriers to addiction treatment, bipolar disorder treatment, and more

2023-11-01
WASHINGTON, D.C., Nov. 1, 2023 — The latest issues of three American Psychiatric Association journals, The American Journal of Psychiatry, Psychiatric Services and Focus, are now available online. The November issue of The American Journal of Psychiatry provides insights into psychotic disorders, such as the altered neurodevelopment and early symptom presentation associated with the risk of developing schizophrenia; racial and ethnic disparities in diagnosis of psychotic episodes; and predictors of first psychotic episodes and its treatment. Highlights include: A Functional Connectome-Based Neural Signature ...

Markey Cancer Center study provides valuable insights into drivers of cancer risk

Markey Cancer Center study provides valuable insights into drivers of cancer risk
2023-11-01
LEXINGTON, Ky. (Oct. 31, 2023) — As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer.   mCAs hold promise as a tool to identify people at high risk of developing certain cancers and diseases, but they have not yet been studied among a large, diverse cohort of people – a critical step required before such testing can be developed.   University of Kentucky Markey Cancer Center researcher Yasminka A. Jakubek, ...

New NIH research looks at life satisfaction in pandemic-era teens with mental health histories

New NIH research looks at life satisfaction in pandemic-era teens with mental health histories
2023-11-01
Collaborative ECHO Cohort research led by Phillip Sherlock, PhD; Maxwell Mansolf, PhD; and Courtney Blackwell, PhD of Northwestern University investigates the COVID-19 pandemic’s impacts on adolescents’ mental health. The findings suggest that some teens with a history of depression, anxiety, autism, and ADHD experienced more severe impacts than those without. This research, titled “Life Satisfaction for Adolescents with Developmental and Behavioral Disabilities during the COVID-19 Pandemic,” is published in Pediatric Research. Although researchers ...

Giant dinosaur carcasses might have been important food sources for Jurassic predators

Giant dinosaur carcasses might have been important food sources for Jurassic predators
2023-11-01
Carnivorous dinosaurs might have evolved to take advantage of giant carcasses, according to a study published November 1, 2023 in the open-access journal PLOS ONE by Cameron Pahl and Luis Ruedas of Portland State University, Oregon and colleagues. Carnivorous dinosaurs lived in ecosystems rich with both living and dead prey. The authors hypothesize that giant carcasses, like those of sauropod dinosaurs, might have provided a major source of food for large carnivores. To test this hypothesis, the researchers created an agent-based model, a simplified virtual simulation of a dinosaur ecosystem. This model was based on the ancient fauna of the Jurassic-aged ...

Game performance of immigrant NBA players might suffer in context of far-right political support

Game performance of immigrant NBA players might suffer in context of far-right political support
2023-11-01
During the 2020-2021 season of the National Basketball Association (NBA), which took place during Donald Trump’s failed bid at re-election, immigrant players for teams in regions with stronger far-right political sentiments were more likely to make game errors—highlighting the possible detrimental effects of such views on immigrant workplace performance. Benjamin Korman and Florian Kunze of the University of Konstanz, Germany, present these findings in the open-access journal PLOS ONE on November 1. Prior research ...

Gulf War Illness significantly reduces white blood cells’ ability to make energy

Gulf War Illness significantly reduces white blood cells’ ability to make energy
2023-11-01
DURHAM, N.C.— A new Duke University-led study finds that Gulf War Illness (GWI), which affects approximately 250,000 U.S. veterans, significantly reduces their white blood cells’ ability to make energy and creates a measurable biochemical difference in veterans who have the disease. “Historically, GWI has been diagnosed based on a veteran’s self-reported symptoms, such as exercise-induced fatigue, indigestion, dizziness, insomnia, or memory problems. There’s been no objective biochemical or molecular measurements doctors could use to diagnose it,” said Joel Meyer, professor of environmental genomics ...

Wistar scientists engineer new NK cell engaging immunotherapy approaches to target and potentially treat recalcitrant ovarian cancer

Wistar scientists engineer new NK cell engaging immunotherapy approaches to target and potentially treat recalcitrant ovarian cancer
2023-11-01
PHILADELPHIA—(Nov. 1, 2023)—The Wistar Institute’s David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center (VIC) and W.W. Smith Charitable Trust Distinguished Professor in Cancer Research, and collaborators, have engineered novel monoclonal antibodies that engage Natural Killer cells through a unique surface receptor that activates the immune system to fight against cancer.  In their publication titled, “Siglec-7 glyco-immune binding MAbs or NK ...

PLOS Complex Systems and PLOS Mental Health now open for submissions!

2023-11-01
SAN FRANCISCO —The Public Library of Science (PLOS) is pleased to announce that PLOS Complex Systems and PLOS Mental Health are now open for submissions. Both journals have a strong community of editors who will represent the full diversity of the research communities we aim to serve. PLOS Mental Health is an inclusive journal led by Editors-in-Chief Charlene Sunkel and Rochelle Burgess, working alongside staff Executive Editor Karli Montague-Cardoso and in collaboration with a diverse Editorial Board. The journal is seeking research that addresses challenges and gaps in the field of mental health research, ...

LAST 30 PRESS RELEASES:

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

T cells take aim at Chikungunya virus

Gantangqing site in southwest China yields 300,000-year-old wooden tools

Forests can’t keep up: Adaptation will lag behind climate change

Sturgeon reintroduction initiative yields promising first-year survival rate

Study: Babies’ poor vision may help organize visual brain pathways

Research reveals Arctic region was permafrost-free when global temperatures were 4.5˚ C higher than today

Novel insights into chromophobe renal cell carcinoma biology and potential therapeutic strategies

A breakthrough in motor safety: AI-powered warning system enhances capability to uncover hidden winding faults

Research teases apart competing transcription organization models

Connect or reject: Extensive rewiring builds binocular vision in the brain

Benefits and risks: informal use of antibiotics to prevent sexually transmitted infections on the rise in key populations in the Netherlands

New molecular tool sheds light on how cancer cells repair telomeres

First large-scale stem cell bank enables worldwide studies on genetic risk for Alzheimer’s disease

Hearing devices significantly improve social lives of those with hearing loss

CNIC scientists reveal how the cellular energy system evolved—and how this knowledge could improve the diagnosis of rare genetic diseases

AI sharpens pathologists' interpretation of tissue samples

Social outcomes among adults with hearing aids and cochlear implants

Passive smartphone sensors for detecting psychopathology

Ireland’s first BioBrillouin microscope will enable non-invasive assessment of living cells and tissues in real-time

Aligned stem cell sheets could improve regenerative therapies

[Press-News.org] Parkinson disease and normal aging