PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Parental age effect on the longevity and healthspan of flies and worms

Parental age effect on the longevity and healthspan of flies and worms
2023-11-21
(Press-News.org)

“[...] little work [has been] published on the effect of parental age in the nematode Caenorhabditis elegans, a common model organism for aging studies.”

BUFFALO, NY- November 16, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans.”

Several studies have investigated the effect of parental age on biological parameters such as reproduction, lifespan, and health; however, the results have been inconclusive, largely due to inter-species variation and/or modest effect sizes.

In their new study, researchers Camille Lenzi, Alexis Piat, Pascal Schlich, Judith Ducau, Jean-Claude Bregliano, Hugo Aguilaniu, and Anne Laurençon from the IM Projet, Caduceum, INRAE, IBDM, Instituto Serrapilheira, and Universite Claude Bernard-Lyon 1 examined the effect of parental age on the lifespan, reproductive capacity, and locomotor activity of genetic isogenic lines of the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. 

“We decided to investigate parental age impact on the lifespan of their progeny on selected genomes of flies and worms to gain insights on the molecular mechanisms at work.”

The researchers found that the progeny of successive generations of old parents had significantly shorter lifespans than the progeny of young parents in both species. Moreover, they investigated the fertility, fecundity, and locomotor activity of C. elegans. Interestingly, both the shorter lifespan and deteriorated healthspan of the progeny were significantly improved by switching to only one generation of younger parents. 

“Collectively, these data demonstrate that the detrimental effect of older parental age on the longevity of the progeny can be reversed, suggesting the existence of a beneficial non–genetic mechanism.”

 

Read the full study: DOI: https://doi.org/10.18632/aging.205098 

Corresponding Author: Anne Laurençon

Corresponding Email: anne.laurencon@ens-lyon.fr 

Keywords: life span, intergenerational plasticity, maternal effect, nematode, drosophila

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205098

 

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud Facebook X, formerly known as Twitter Instagram YouTube LabTube LinkedIn Reddit Pinterest  

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

END


[Attachments] See images for this press release:
Parental age effect on the longevity and healthspan of flies and worms Parental age effect on the longevity and healthspan of flies and worms 2 Parental age effect on the longevity and healthspan of flies and worms 3

ELSE PRESS RELEASES FROM THIS DATE:

Two new UW–Madison-led studies inform outlook on scaling of carbon removal technologies

2023-11-21
MADISON, Wis., - Carbon dioxide removal (CDR) technologies that could be critical tools to combat climate change have developed in line with other technologies from the last century. However, according to new studies led by Gregory Nemet, a professor at the University of Wisconsin–Madison, these technologies need to develop faster to meet policy targets aimed at limiting global warming. As policymakers, researchers and climate activists from around the world prepare to meet for the UN Climate Change Conference beginning on ...

Nuclear physics traineeship program offers launchpad for research careers

Nuclear physics traineeship program offers launchpad for research careers
2023-11-21
Associate Professor of physics Benjamin Jones has received a $341,571 grant from the U.S. Department of Energy to continue his successful traineeship program at The University of Texas at Arlington. The program exposes undergraduate students to opportunities in particle and nuclear physics, which offer key components in many diverse careers, such as nuclear medicine, radiation therapy, archaeology, precision management and astrophysics. UTA’s Nuclear Research Experiences for Minority Students (NREMST) started in 2021 with the goal of immersing students from historically underrepresented populations in nuclear physics. “We know that many students ...

Experts from the UK and South America join forces for major new study of mental health reform

2023-11-21
A major new research project will explore the impact of transformational changes to mental health treatment in South America.   Community-based care for people with psychosocial disabilities began in the region in the 1960s and 1970s, when a minority of people were moved from large and isolated psychiatric hospitals to  residential alternatives in the community.   This policy was promoted by the World Health Organization and the Pan America Health Organization and is considered a defining element of the modernisation of mental health systems. But in current analysis of this process the ethical, social and political tensions associated ...

Bacteria store memories and pass them on for generations

Bacteria store memories and pass them on for generations
2023-11-21
Scientists have discovered that bacteria can create something like memories about when to form strategies that can cause dangerous infections in people, such as resistance to antibiotics and bacterial swarms when millions of bacteria come together on a single surface. The discovery — which has potential applications for preventing and combatting bacterial infections and addressing antibiotic-resistant bacteria — relates to a common chemical element bacterial cells can use to form and pass along these memories to their progeny over later generations. Researchers ...

Forest modeling shows which harvest rotations lead to maximum carbon sequestration

Forest modeling shows which harvest rotations lead to maximum carbon sequestration
2023-11-21
CORVALLIS, Ore. – Forest modeling by Oregon State University scientists shows that a site’s productivity – an indicator of how fast trees grow and how much biomass they accumulate – is the main factor that determines which time period between timber harvests allows for maximum above-ground carbon sequestration. The findings, published in the journal Forests, are important for Pacific Northwest forest managers seeking to strike an optimal balance between harvesting and carbon sequestration, an important tool in the fight against climate change. The study by Catherine Carlisle, Temesgen Hailemariam ...

The bilingual brain may be better at ignoring irrelevant information

2023-11-21
People who speak two languages may be better at shifting their attention from one thing to another compared to those who speak one, according to a study published this month in the journal Bilingualism: Language and Cognition.  The study examined differences between bilingual and monolingual individuals when it comes to attentional control and ignoring information that isn’t important at the time, said its authors Grace deMeurisse, a University of Florida Ph.D. candidate studying linguistics, and Edith Kaan, ...

Promising target for CAR T cells helps cancer trick the immune system

Promising target for CAR T cells helps cancer trick the immune system
2023-11-21
(MEMPHIS, Tenn. – November 21, 2023) Findings from St. Jude Children’s Research Hospital are moving the field of cancer immunotherapy one step closer to treating brain and solid tumors. Scientists at St. Jude validated a cellular immunotherapy target called 78-kDa glucose-regulated protein (GRP78) in proof-of-principle experiments. The group also discovered a resistance mechanism whereby some tumors trick the cancer-killing immune cells into expressing GRP78, thereby turning off the immune cells or causing them to be killed, too. The research, which has implications for developing immunotherapy for the broad range of difficult-to-treat ...

Researchers help unravel brain processes involved in vision

Researchers help unravel brain processes involved in vision
2023-11-21
TORONTO, Nov. 21, 2023 – Faced with images that break the expected pattern, like a do not enter sign where a stop sign is expected, how does the brain react and learn compared to being shown images which match what was predicted? That was the question a team, including York University, set out to answer. A long-standing theory suggests the brain learns a predictive model of the world and its internal predictions are updated when incoming sensory data proves them wrong. However, what the researchers found surprised them, says York Faculty of Science Associate Professor Joel Zylberberg, co-corresponding author of the newly published paper. “Testing ...

Unearthing how a carnivorous fungus traps and digests worms

Unearthing how a carnivorous fungus traps and digests worms
2023-11-21
A new analysis sheds light on the molecular processes involved when a carnivorous species of fungus known as Arthrobotrys oligospora senses, traps and consumes a worm. Hung-Che Lin of Academia Sinica in Taipei, Taiwan, and colleagues present these findings November 21st in the open access journal PLOS Biology. A. oligospora usually derives its nutrients from decaying organic matter, but starvation and the presence of nearby worms can prompt it to form traps to capture and consume worms. A. oligospora is just one of many species of fungi that can trap and eat very small animals. Prior research has illuminated some of the biology behind this ...

Taxing sugar-sweetened beverages in Germany would improve population health and save money

Taxing sugar-sweetened beverages in Germany would improve population health and save money
2023-11-21
In Germany, taxing sugar-sweetened beverages could prevent or postpone cases of type 2 diabetes, extend healthy lifespans and save up to €16.0 billion in societal costs over the next 20 years, according to a new study led by Karl Emmert-Fees of the Technical University of Munich, published November 21st in the open access journal PLOS Medicine. The World Health Organization has recommended that governments worldwide lessen the social and economic burden of cardiometabolic disease by taxing sugar-sweetened beverages. These taxes either reduce consumption by increasing the price, such as the one peso per liter ...

LAST 30 PRESS RELEASES:

Fig trees convert atmospheric CO2 to stone

Intra-arterial tenecteplase for acute stroke after successful endovascular therapy

Study reveals beneficial microbes that can sustain yields in unfertilized fields

Robotic probe quickly measures key properties of new materials

Climate change cuts milk production, even when farmers cool their cows

Frozen, but not sealed: Arctic Ocean remained open to life during ice ages

Some like it cold: Cryorhodopsins

Demystifying gut bacteria with AI

Human wellbeing on a finite planet towards 2100: new study shows humanity at a crossroads

Unlocking the hidden biodiversity of Europe’s villages

Planned hydrogen refuelling stations may lead to millions of euros in yearly losses

Planned C-sections increase the risk of certain childhood cancers

Adults who have survived childhood cancer are at increased risk of severe COVID-19

Drones reveal extreme coral mortality after bleaching

New genetic finding uncovers hidden cause of arsenic resistance in acute promyelocytic leukemia

Native habitats hold the key to the much-loved smashed avocado’s future

Using lightning to make ammonia out of thin air

Machine learning potential-driven insights into pH-dependent CO₂ reduction

Physician associates provide safe care for diagnosed patients when directly supervised by a doctor

How game-play with robots can bring out their human side

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

[Press-News.org] Parental age effect on the longevity and healthspan of flies and worms